Molecular interplay between cdk4 and p21 dictates G0/G1 cell cycle arrest in prostate cancer cells

Gulappa, Thippeswamy; Reddy, Ramadevi Subramani; Suman, Suman; Nyakeriga, Alice M.; Damodaran, Chendil

doi:10.1016/j.canlet.2013.05.014

Cited by 43Prostate Cancer Treatment and ResearchCancer-related Molecular PathwaysSynthesis and biological activity

Molecular interplay between cdk4 and p21 dictates G0/G1 cell cycle arrest in prostate cancer cells

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Gulappa, Thippeswamy, Reddy, Ramadevi Subramani, Suman, Suman, Nyakeriga, Alice M., Damodaran, Chendil·2013·Cancer Letters

DOI 10.1016/j.canlet.2013.05.014PMC PMC3752915

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Abstract

This study examined the effect of 3, 9-dihydroxy-2-prenylcoumestan (pso), a furanocoumarin, on PC-3 and C4-2B castration-resistant prostate cancer (CRPC) cell lines. Pso caused significant G0/G1 cell cycle arrest and inhibition of cell growth. Molecular analysis of cyclin (D1, D2, D3, and E), cyclin-dependent kinase (cdk) (cdks 2, 4, and 6), and cdk inhibitor (p21 and p27) expression suggested transcriptional regulation of the cdk inhibitors and more significant downregulation of cdk4 than of cyclins or other cdks. Overexpression of cdk4, or silencing of p21 or p27, overcame pso-induced G0/G1 arrest, suggesting that G0/G1 cell cycle arrest is a potential mechanism of growth inhibition in CRPC cells.

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p21 also causes cell-cycle arrest in G0 in different settings.
“p21 also causes cell-cycle arrest in G 0 in different settings (43,44)”
From Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21 (2022) · cites this paper as [44]
The Results (§3.5; page unavailable) show that knocking down p21 attenuated psoralidin-induced G0/G1 arrest in PC-3 prostate cancer cells. This supports a role for p21 in arrest, but the paper does not establish arrest specifically in G0 or across the broader range of settings implied by the claim. (LLM, conf=0.86)
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Abstract 559: The molecular kinetics of p21 and Cdk4 dictates irreversible G0/G1 phase cell cycle arrest in CRPC cells.
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Authors: Gulappa, T., Reddy, R. S., Suman, S., Nyakeriga, A. M., & Damodaran, C.
Affiliations: Texas Tech University Health Sciences Center (US)
Corresponding author: Damodaran, Chendil
ORCID: Damodaran, Chendil
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2013-09
Volume: 337
Issue: 2
Pages: 177-183
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2013.05.014
PMC: PMC3752915
OpenAlex: W1974026054
Cited by: 43
References: 48
Citations by year: 2026: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 4
FWCI: 3.80
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA138797, R01CA140605)
National Center for Complementary and Integrative Health (R01AT002890)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
Keywords: castration-resistant prostate cancer, G0/G1 cell cycle arrest, CDK4, p21, p27, cyclin-dependent kinases, cyclins, cell growth inhibition, PC-3 cells, C4-2B cells
MeSH terms: Cell Survival, Dose-Response Relationship, Drug, Humans, Male, Phosphorylation, Prostatic Neoplasms, Furocoumarins, Time Factors, Transcription, Genetic, Transfection, Signal Transduction, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Retinoblastoma Protein, Resting Phase, Cell Cycle, RNA Interference, Cell Line, Tumor, E2F1 Transcription Factor, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor p27, Cyclin-Dependent Kinase 4, G1 Phase Cell Cycle Checkpoints

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Molecular interplay between cdk4 and p21 dictates G0/G1 cell cycle arrest in prostate cancer cells

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