Cited by 346Phytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stressBioactive natural compounds

Chemopreventive effects of natural dietary compounds on cancer development

Pan, Min-Hsiung, Ho, Chi-Tang·2008·Chemical Society Reviews

Abstract

Chemoprevention, a relatively new and promising strategy to prevent cancer, is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the process of carcinogenesis. The chemopreventive effects elicited by these natural dietary compounds are believed to include antioxidative, anti-inflammatory activity, induction of phase II enzymes, apoptosis, and cell cycle arrest. Many mechanisms have been shown to account for the anticarcinogenic actions of natural dietary compounds; attention has recently been focused on intracellular-signaling cascades as common molecular targets for various chemopreventive natural dietary compounds. In this critical review, we will summarize current knowledge on natural dietary compounds that act through the signaling pathways and modulate gene expression to induce detoxifying enzymes, programmed cell death, anti-inflammatory, and anti-proliferative effects, thus providing evidence for these substances in cancer chemopreventive action (128 references).

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Crossref · 10.1039/b801558a

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Authors
Pan, M.-H., & Ho, C.-T.
Affiliations
  • National Kaohsiung Marine University (TW)
  • Rutgers, The State University of New Jersey (US)
Corresponding author
Ho, Chi-Tang
Venue
Chemical Society Reviews
Published
2008
Volume
37
Issue
11
Pages
2558
ISSN
  • 0306-0012 (ISSN-L)
  • 1460-4744
OpenAlex
W2046704995
Cited by
346
References
121
Citations by year
2026: 4 · 2025: 5 · 2024: 11 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 19 · 2019: 18 · 2018: 17 · 2017: 25 · 2016: 19 · 2015: 31 · 2014: 35 · 2013: 38 · 2012: 27
FWCI
1.74
Type
journal article
Language
en
Open access
closed
Locations
  • Chemical Society Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords
chemoprevention, carcinogenesis, phase II enzymes, apoptosis, cell cycle arrest, anti-inflammatory activity, antioxidant activity, intracellular signaling, gene expression modulation, antiproliferative activity
MeSH terms
Animals, Antioxidants, Carotenoids, Cell Cycle, Diet, Enzyme Induction, Flavonoids, Humans, Neoplasms, Terpenes, Fatty Acids, Omega-3, Anticarcinogenic Agents, Apoptosis, Isothiocyanates, Proanthocyanidins, Flavonolignans

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