Chemopreventive effects of natural dietary compounds on cancer development
Abstract
Chemoprevention, a relatively new and promising strategy to prevent cancer, is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the process of carcinogenesis. The chemopreventive effects elicited by these natural dietary compounds are believed to include antioxidative, anti-inflammatory activity, induction of phase II enzymes, apoptosis, and cell cycle arrest. Many mechanisms have been shown to account for the anticarcinogenic actions of natural dietary compounds; attention has recently been focused on intracellular-signaling cascades as common molecular targets for various chemopreventive natural dietary compounds. In this critical review, we will summarize current knowledge on natural dietary compounds that act through the signaling pathways and modulate gene expression to induce detoxifying enzymes, programmed cell death, anti-inflammatory, and anti-proliferative effects, thus providing evidence for these substances in cancer chemopreventive action (128 references).
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Cancer preventive compounds may stimulate anticancer immunity, inhibit inflammation, angiogenesis and tumor invasion, or protect from UV-radiation damage.
“Cancer preventive compounds may stimulate anticancer immunity, inhibit inflammation, angiogenesis and tumor invasion, or protect from UV-radiation damage [144,145,146,147].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [145]
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New Bioactive Orange Pigments with Yellow Fluorescence from Monascus-Fermented Dioscorea
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- Authors
- Pan, M.-H., & Ho, C.-T.
- Affiliations
- National Kaohsiung Marine University (TW)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Ho, Chi-Tang
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2008
- Volume
- 37
- Issue
- 11
- Pages
- 2558
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2046704995
- Cited by
- 346
- References
- 121
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 19 · 2019: 18 · 2018: 17 · 2017: 25 · 2016: 19 · 2015: 31 · 2014: 35 · 2013: 38 · 2012: 27
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Society Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- chemoprevention, carcinogenesis, phase II enzymes, apoptosis, cell cycle arrest, anti-inflammatory activity, antioxidant activity, intracellular signaling, gene expression modulation, antiproliferative activity
- MeSH terms
- Animals, Antioxidants, Carotenoids, Cell Cycle, Diet, Enzyme Induction, Flavonoids, Humans, Neoplasms, Terpenes, Fatty Acids, Omega-3, Anticarcinogenic Agents, Apoptosis, Isothiocyanates, Proanthocyanidins, Flavonolignans
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