A prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766

Tumor-Associated Macrophages: From Mechanisms to Therapy

Noy, R., & Pollard, J. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.010 · Cited by 4,089

Targeting hypoxia in cancer therapy

Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172

Hypoxia in cancer: significance and impact on clinical outcome

Vaupel, P., & Mayer, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9055-1 · Cited by 2,240

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

Holmgren, L., O’Reilly, M. S., & Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0295-149 · Cited by 1,891

HIF-1α pathway: role, regulation and intervention for cancer therapy

Masoud, G. N., & Li, W. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.05.007 · Cited by 1,871

Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

Singh, B. N., Shankar, S., & Srivastava, R. K. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.093 · Cited by 1,652

PI3K/AKT/mTOR Pathway in Angiogenesis

Karar, J., & Maity, A. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00051 · Cited by 1,493

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

Solinas, G., Germano, G., Mantovani, A., & Allavena, P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0609385 · Cited by 1,456

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

Genin, M., Clement, F., Fattaccioli, A., Raes, M., & Michiels, C. (2015) · BMC Cancer · doi:10.1186/s12885-015-1546-9 · Cited by 1,090

The origin and function of tumor-associated macrophages

Mantovani, A., Bottazzi, B., Colotta, F., Sozzani, S., & Ruco, L. P. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90008-u · Cited by 1,088

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

Liu, Y., Cox, S. R., Morita, T., & Kourembanas, S. (1995) · Circulation Research · doi:10.1161/01.res.77.3.638 · Cited by 1,049

Tumor angiogenesis: past, present and the near future

Kerbel, R. S. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.505 · Cited by 985

VEGFA and tumour angiogenesis

Claesson, L., & Welsh, M. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12019 · Cited by 875

Tumor-associated macrophages: from basic research to clinical application

Yang, L., & Zhang, Y. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0430-2 · Cited by 847

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

Polivka, J., & Janku, F. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.12.004 · Cited by 765

Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions

Vasudev, N. S., & Reynolds, A. R. (2014) · Angiogenesis · doi:10.1007/s10456-014-9420-y · Cited by 758

Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis

Riabov, V., Gudima, A., Wang, N., Mickley, A., Orekhov, A. N., & Kzhyshkowska, J. G. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00075 · Cited by 655

Tumor-associated macrophages: Effectors of angiogenesis and tumor progression

Coffelt, S. B., Hughes, R., & Lewis, C. E. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.02.004 · Cited by 358

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.

Parangi, S., OʼReilly, M., Christofori, G., Holmgren, L., Grosfeld, J. A., Folkman, J., & Hanahan, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.2002 · Cited by 343

A Novel Prodrug of the Green Tea Polyphenol (−)-Epigallocatechin-3-Gallate as a Potential Anticancer Agent

Landis‐Piwowar, K. R., Huo, C., Chen, D., Milacic, V., Shi, G., Chan, T. H., & Dou, Q. P. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4699 · Cited by 236

Angiogenic factors as potential drug target: Efficacy and limitations of anti-angiogenic therapy

Gacche, R. N., & Meshram, R. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.05.002 · Cited by 203

Green tea and its anti-angiogenesis effects

Rashidi, B., Malekzadeh, M., Goodarzi, M., Masoudifar, A., & Mirzaei, H. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.161 · Cited by 200

Clinical and Biological Significance of Vascular Endothelial Growth Factor in Endometrial Cancer

Kamat, A. A., Merritt, W. M., Coffey, D., Lin, Y. G., Patel, P. R., Broaddus, R. R., Nugent, E. K., Han, L. Y., Landen, C. N., Spannuth, W. A., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1017 · Cited by 194

EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression

Gu, J., Makey, K. L., Tucker, K. B., Chinchar, E., Mao, X., Pei, I., Thomas, E. Y., & Miele, L. (2013) · Vascular Cell · doi:10.1186/2045-824x-5-9 · Cited by 194

Tumour-associated macrophages and cancer

Cook, J. A., & Hagemann, T. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.05.017 · Cited by 173

Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model

Wang, S., Hong, J., Hsueh, C., & Chiang, C. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.128 · Cited by 172

Targeting Tumor-Infiltrating Macrophages to Combat Cancer

Panni, R. Z., Linehan, D. C., & DeNardo, D. G. (2013) · Immunotherapy · doi:10.2217/imt.13.102 · Cited by 155

A potential prodrug for a green tea polyphenol proteasome inhibitor: evaluation of the peracetate ester of (−)-epigallocatechin gallate [(−)-EGCG]

Lam, W. H., Kazi, A., Kuhn, D. J., Chow, L. M. C., Chan, A. S. C., Dou, Q. P., & Chan, T. H. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.08.002 · Cited by 148

Molecular Mechanisms of Tumor Angiogenesis and Tumor Progression

Cavallaro, U., & Christofori, G. (2000) · Journal of Neuro-Oncology · doi:10.1023/a:1006414621286 · Cited by 139

Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice

Wang, C. C., Xu, H., Man, G. C. W., Zhang, T., Chu, K. O., Chu, C. Y., Cheng, J. T. Y., Li, G., He, Y., Qin, L., et al. (2012) · Angiogenesis · doi:10.1007/s10456-012-9299-4 · Cited by 125

The role of tumor-associated macrophages in tumor vascularization

Guo, C., Buranych, A., Sarkar, D., Fisher, P. B., & Wang, X. (2013) · Vascular Cell · doi:10.1186/2045-824x-5-20 · Cited by 118

Expression of Vascular Endothelial Growth Factors (VEGF-A/VEGF-1 and VEGF-C/VEGF-2) in Postmenopausal Uterine Endometrial Carcinoma

Hirai, M., Nakagawara, A., 大崎, 達., Hayashi, Y., Hirono, M., & Yoshihara, T. (2001) · Gynecologic Oncology · doi:10.1006/gyno.2000.6056 · Cited by 109

Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo

Xu, H., Becker, C. M., Lui, W. T., Chu, C. Y., Davis, T. N., Kung, A. L., Birsner, A. E., D’Amato, R. J., Man, G. C. W., & Wang, C. C. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.07.008 · Cited by 107

Antiangiogenic Therapies: Going beyond Their Limits

Moserle, L., Jiménez-Valerio, G., & Casanovas, O. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0199 · Cited by 105

Molecularly targeting the PI3K-Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapy

Wang, Z., Huang, Y., & Zhang, J. (2014) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-014-0191-7 · Cited by 82

Effect of a Prodrug of the Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate on the Growth of Androgen-Independent Prostate Cancer In Vivo

Lee, S.-C., Chan, W.-K., Lee, T.-W., Lam, W. H., Wang, X., Chan, T. H., & Wong, Y.-C. (2008) · Nutrition and Cancer · doi:10.1080/01635580801947674 · Cited by 76

Macrophage infiltration and angiogenesis in endometrial cancer.

Hashimoto, I., Kodama, J., Seki, N., Hongo, A., Miyagi, Y., Yoshinouchi, M., & Kudo, T. (2000) · PubMed · Cited by 45

Targeting angiogenesis in endometrial cancer - new agents for tailored treatments

Papa, A., Zaccarelli, E., Caruso, D., Vici, P., Panici, P. B., & Tomao, F. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2016.1116517 · Cited by 42

Hypoxia‐Inducible Factor‐1 as a Therapeutic Target in Endometrial Cancer Management

Seeber, L. M. S., Zweemer, R. P., Verheijen, R. H. M., & van Diest, P. J. (2010) · Obstetrics and Gynecology International · doi:10.1155/2010/580971 · Cited by 27

Emerging strategies for targeting PI3K in gynecologic cancer

Bregar, A. J., & Growdon, W. B. (2015) · Gynecologic Oncology · doi:10.1016/j.ygyno.2015.09.083 · Cited by 25

Tumor-associated macrophages: Co-conspirators and orchestrators of immune suppression in endometrial adenocarcinoma

Zsíros, E., & Odunsi, K. O. (2014) · Gynecologic Oncology · doi:10.1016/j.ygyno.2014.10.012 · Cited by 16

Serotonin Receptor 6 Mediates Defective Brain Development in Monoamine Oxidase A-deficient Mouse Embryos

Wang, C. C., Man, G. C. W., Chu, C. Y., Borchert, A., Ugun‐Klusek, A., Billett, E. E., Kühn, H., & Ufer, C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.522094 · Cited by 14

Biological markers with potential clinical value in endometrial cancer — review of the literature

Taoussi, N., Alghamdi, A. J., Futyma, K., & Rechberger, T. (2017) · Ginekologia Polska · doi:10.5603/gp.a2017.0062 · Cited by 14

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Luo, H., Vong, C. T., Chen, H., Gao, Y., Lyu, P., Qiu, L., Zhao, M., Liu, Q., Cheng, Z., Zou, J., et al. (2019) · Chinese Medicine · doi:10.1186/s13020-019-0270-9 · Cited by 569

Drug repurposing for cancer therapy

Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443

Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer

Almatroodi, S. A., Almatroudi, A., Khan, A. A., Alhumaydhi, F. A., Alsahli, M. A., & Rahmani, A. H. (2020) · Molecules · doi:10.3390/molecules25143146 · Cited by 369

Bioavailability of Tea Catechins and Its Improvement

Cai, Z., Li, X.-M., Liang, J.-P., Xiang, L., Wang, K., Shi, Y., Yang, R., Shi, M., Ye, J., Lu, J., et al. (2018) · Molecules · doi:10.3390/molecules23092346 · Cited by 333

Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel

Han, K., Nam, J., Xu, J., Sun, X., Huang, X., Animasahun, O., Achreja, A., Jeon, J. H., Pursley, B., Kamada, N., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00749-2 · Cited by 287

Abstract 162: A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate served as a potentially novel angiogenesis inhibitor in endometrioid endometrial cancer

Wang, J., Man, G. C. W., Yang, X., Kwong, J., Dou, Q. P., Chan, T. H., & Wang, C. C. (2017) · Cancer Research · doi:10.1158/1538-7445.am2017-162 · Cited by 1

Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice

Wang, C. C., Xu, H., Man, G. C. W., Zhang, T., Chu, K. O., Chu, C. Y., Cheng, J. T. Y., Li, G., He, Y., Qin, L., et al. (2012) · Angiogenesis · doi:10.1007/s10456-012-9299-4 · Cited by 125

Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo

Xu, H., Becker, C. M., Lui, W. T., Chu, C. Y., Davis, T. N., Kung, A. L., Birsner, A. E., D’Amato, R. J., Man, G. C. W., & Wang, C. C. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.07.008 · Cited by 107

Inhibitory effects of epigallocatechin‐3 gallate, a polyphenol in green tea, on tumor‐associated endothelial cells and endothelial progenitor cells

Ohga, N., Hida, K., Hida, Y., Muraki, C., Tsuchiya, K., Matsuda, K., Ohiro, Y., Totsuka, Y., & Shindoh, M. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01255.x · Cited by 92

Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer

Man, G. C. W., Wang, J., Song, Y., Wong, J. H., Zhao, Y. F., Lau, T., Leung, K. T., Chan, T. H., Wang, H., Kwong, J., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-07455-3 · Cited by 38