Ultrasound nanotheranostics in fighting cancer: Advances and prospects
Abstract
The intrinsic limits of conventional ultrasound microbubble contrast agent greatly promoted the development and application of various nanomaterials for more efficient cancer ultrasound theranostics. Considerable successes have been achieved in the field of ultrasound molecular imaging and targeted therapy for tumor based on nanoparticulate theranostic agents. This review summarizes and discusses the emerging development on exploring organic and inorganic nanomaterials for ultrasound-based tumor diagnositic applications, and as synergistic agents for ultrasound targeted therapy in fighting cancer. The relationship between structure/composition and functionality of nanomaterials for ultrasound theranostic is discussed and revealed in detail. Finally, the further development and challenges facing clinical implementation of ultrasound nanomedicine are discussed. As a highly promising and valuable tumor-specific theranostic methodology, it is believed that ultrasound nanomedicine would pave a novel but efficient way for combating cancer.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ultrasound has become a common external trigger approach for cancer treatment.
“As a result, it has become a common external trigger approach for cancer treatment.177,178”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [177]
Cites
Cancer nanomedicine: progress, challenges and opportunities
Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works
Dysregulated pH: a perfect storm for cancer progression
Webb, B. A., Chimenti, M. S., Jacobson, M. P., & Barber, D. L. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3110 · Cited by 2,246 · see citing works
Gold nanorods and their plasmonic properties
Chen, H., Shao, L., Li, Q., & Wang, J. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35367a · Cited by 1,837 · see citing works
Freestanding palladium nanosheets with plasmonic and catalytic properties
Huang, X., Tang, S., Mu, X., Dai, Y., Chen, G., Zhou, Z., Ruan, F., Yang, Z., & Zheng, N. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.235 · Cited by 1,602 · see citing works
Lovell, J. F., Jin, C. S., Huynh, E., Jin, H., Kim, C., Rubinstein, J. L., Chan, W. C. W., Cao, W., Wang, L. V., & Zheng, G. (2011) · Nature Materials · doi:10.1038/nmat2986 · Cited by 1,364 · see citing works
Targeting of drugs and nanoparticles to tumors
Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200910104 · Cited by 833 · see citing works
Qiu, M., Wang, D., Liang, W., Liu, L., Zhang, Y., Chen, X., Sang, D. K., Xing, C., Li, Z., Dong, B., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714421115 · Cited by 814 · see citing works
Targeted pharmaceutical nanocarriers for cancer therapy and imaging
Torchilin, V. P. (2007) · The AAPS Journal · doi:10.1208/aapsj0902015 · Cited by 758 · see citing works
Sheng, Z., Hu, D., Zheng, M., Zhao, P., Liu, H., Gao, D., Gong, P., Gao, G., Zhang, P., Ma, Y., et al. (2014) · ACS Nano · doi:10.1021/nn5062386 · Cited by 719 · see citing works
Mesoporous silica nanoparticles in medicine—Recent advances
Mamaeva, V., Sahlgren, C., & Lindén, M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.018 · Cited by 709 · see citing works
Huang, P., Qian, X., Chen, Y., Yu, L., Lin, H., Wang, L., Zhu, Y., & Shi, J. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b11846 · Cited by 666 · see citing works
Gold Nanoparticles for Photoacoustic Imaging
Li, W., & Chen, X. S. (2015) · Nanomedicine · doi:10.2217/nnm.14.169 · Cited by 633 · see citing works
Yue, W., Chen, L., Yu, L., Zhou, B., Yin, H., Ren, W., Liu, C., Guo, L., Zhang, Y., Sun, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09760-3 · Cited by 590 · see citing works
Nanotechnology in hyperthermia cancer therapy: From fundamental principles to advanced applications
Beik, J., Abed, Z., Ghoreishi, F. S., Hosseini-Nami, S., Mehrzadi, S., Shakeri‐Zadeh, A., & Kamrava, S. K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.062 · Cited by 581 · see citing works
Gold Nanocages for Biomedical Applications
Skrabalak, S. E., Chen, J., Au, L., Lu, X., Li, X. D., & Younan Xia, A. (2007) · Advanced Materials · doi:10.1002/adma.200701972 · Cited by 508 · see citing works
Metal–Organic‐Framework‐Derived Carbon Nanostructure Augmented Sonodynamic Cancer Therapy
Pan, X., Bai, L., Wang, H., Wu, Q., Wang, H., Liu, S., Xu, B., Shi, X., & Liu, H. (2018) · Advanced Materials · doi:10.1002/adma.201800180 · Cited by 493 · see citing works
Polymer-Grafted Mesoporous Silica Nanoparticles as Ultrasound-Responsive Drug Carriers
Paris, J. L., Cabañas, M. V., Manzano, M., & Vallet‐Regí, M. (2015) · ACS Nano · doi:10.1021/acsnano.5b04378 · Cited by 484 · see citing works
Noninvasive Imaging of Nanomedicines and Nanotheranostics: Principles, Progress, and Prospects
Kunjachan, S., Ehling, J., Storm, G., Kiessling, F. M., & Lammers, T. (2015) · Chemical Reviews · doi:10.1021/cr500314d · Cited by 480 · see citing works
Li, J., Rao, J., & Pu, K. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.025 · Cited by 469 · see citing works
Functionalized graphene nanocomposites for enhancing photothermal therapy in tumor treatment
Chen, Y., Su, Y.-L., Hu, S., & Chen, S. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.05.022 · Cited by 466 · see citing works
Han, X., Huang, J., Jing, X., Yang, D., Lin, H., Wang, Z., Li, P., & Chen, Y. (2018) · ACS Nano · doi:10.1021/acsnano.8b00899 · Cited by 438 · see citing works
Self-citationChen, M., Tang, S., Guo, Z., Wang, X., Mo, S., Huang, X., Liu, G., & Zheng, N. (2014) · Advanced Materials · doi:10.1002/adma.201404013 · Cited by 425 · see citing works
Chen, Q., Liang, C., Wang, C., & Liu, Z. (2015) · Advances in Materials · doi:10.1002/adma.201404308 · Cited by 416 · see citing works
Moon, G. D., Choi, S. W., Cai, X., Li, W., Cho, E. C., Jeong, U., Wang, L. V., & Younan Xia, A. (2011) · Journal of the American Chemical Society · doi:10.1021/ja200894u · Cited by 405 · see citing works
Carbon nanotubes for biomedical imaging: The recent advances
Gong, H., Peng, R., & Liu, Z. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.10.002 · Cited by 388 · see citing works
Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts
Bourdeau, R. W., Lee‐Gosselin, A., Lakshmanan, A., Farhadi, A., Kumar, S. R., Nety, S. P., & Shapiro, M. G. (2018) · Nature · doi:10.1038/nature25021 · Cited by 386 · see citing works
Ultrasound contrast imaging: current and new potential methods
Frinking, P. J. A., Bouakaz, A., Kirkhorn, J., ten Cate, F. J., & de Jong, N. (2000) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(00)00229-5 · Cited by 378 · see citing works
Biogenic gas nanostructures as ultrasonic molecular reporters
Shapiro, M. G., Goodwill, P. W., Neogy, A., Yin, M., Foster, F. S., Schaffer, D. V., & Conolly, S. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.32 · Cited by 367 · see citing works
Distribution, formation and regulation of gas vesicles
Pfeifer, F. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2834 · Cited by 350 · see citing works
ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer
You, D. G., Deepagan, V. G., Um, W., Jeon, S., Son, S., Chang, H., Yoon, H. I., Cho, Y. W., Swierczewska, M., Lee, S., et al. (2016) · Scientific Reports · doi:10.1038/srep23200 · Cited by 328 · see citing works
Chen, Y., Chen, H., & Shi, J. (2013) · Accounts of Chemical Research · doi:10.1021/ar400091e · Cited by 324 · see citing works
Sheeran, P. S., Luois, S., Dayton, P. A., & Matsunaga, T. O. (2011) · Langmuir · doi:10.1021/la2013705 · Cited by 310 · see citing works
Dye‐Loaded Ferritin Nanocages for Multimodal Imaging and Photothermal Therapy
Huang, P., Rong, P., Jin, A. J., Yan, X., Zhang, M. G., Lin, J., Hu, H., Wang, Z., Yue, X., Li, W., et al. (2014) · Advanced Materials · doi:10.1002/adma.201400914 · Cited by 304 · see citing works
Chu, J., Oh, Y., Sens, A., Ataie, N., Dana, H., Macklin, J. J., Laviv, T., Welf, E. S., Dean, K. M., Zhang, F., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3550 · Cited by 284 · see citing works
Min, K. H., Min, H. S., Lee, H. J., Park, D. J., Yhee, J. Y., Kim, K., Kwon, I. C., Jeong, S. Y., Silvestre, Ó. F., Chen, X. S., et al. (2015) · ACS Nano · doi:10.1021/nn506210a · Cited by 265 · see citing works
Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications
Wang, S., Lin, J., Wang, T., Chen, X. S., & Huang, P. (2016) · Theranostics · doi:10.7150/thno.16715 · Cited by 262 · see citing works
Kim, C., Song, K. H., Gao, F., & Wang, L. V. (2010) · Radiology · doi:10.1148/radiol.10090281 · Cited by 261 · see citing works
Gao, S., Wang, G., Qin, Z., Wang, X., Zhao, G., Ma, Q., & Zhu, L. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.030 · Cited by 260 · see citing works
Sono‐Immunotherapeutic Nanocapturer to Combat Multidrug‐Resistant Bacterial Infections
Pang, X., Liu, X., Cheng, Y., Zhang, C., Ren, E., Liu, L., Zhang, Y., Zhu, J. X., Chen, X. S., & Liu, G. (2019) · Advanced Materials · doi:10.1002/adma.201902530 · Cited by 238 · see citing works
Wang, X., Chen, H., Chen, Y., Ma, M., Zhang, K., Li, F., Zheng, Y., Zeng, D., Wang, Q., & Shi, J. (2012) · Advanced Materials · doi:10.1002/adma.201104033 · Cited by 236 · see citing works
Recent advances in carbon based nanosystems for cancer theranostics
Augustine, S., Singh, J., Srivastava, M., Sharma, M., Das, A., & Malhotra, B. D. (2017) · Biomaterials Science · doi:10.1039/c7bm00008a · Cited by 234 · see citing works
A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia
Knox, H. J., Hedhli, J., Kim, T. W., Khalili, K., Dobrucki, L. W., & Chan, J. (2017) · Nature Communications · doi:10.1038/s41467-017-01951-0 · Cited by 222 · see citing works
Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure
Suzuki, R., Namai, E., Oda, Y., 功人, 西., Otake, S., Koshima, R., Hirata, K., Taira, Y., Utoguchi, N., Negishi, Y., et al. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.10.027 · Cited by 207 · see citing works
Kempen, P. J., Greasley, S. L., Parker, K. A., Campbell, J. L., Chang, H.-Y., Jones, J. R., Sinclair, R., Gambhir, S. S., & Jokerst, J. V. (2015) · Theranostics · doi:10.7150/thno.11389 · Cited by 205 · see citing works
Jin, Y., Wang, J., Ke, H., Wang, S., & Dai, Z. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.027 · Cited by 197 · see citing works
Folding Up of Gold Nanoparticle Strings into Plasmonic Vesicles for Enhanced Photoacoustic Imaging
Liu, Y., He, J., Yang, K., Yi, C., Liu, Y., Nie, L., Khashab, N. M., Chen, X. S., & Nie, Z. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201508616 · Cited by 180 · see citing works
Preparation of biogenic gas vesicle nanostructures for use as contrast agents for ultrasound and MRI
Lakshmanan, A., Lu, G. J., Farhadi, A., Nety, S. P., Kunth, M., Lee‐Gosselin, A., Maresca, D., Bourdeau, R. W., Yin, M., Yan, J., et al. (2017) · Nature Protocols · doi:10.1038/nprot.2017.081 · Cited by 167 · see citing works
Gao, F., He, G., Yin, H., Chen, J., Liu, Y., Lan, C., Zhang, S., & Yang, B. (2019) · Nanoscale · doi:10.1039/c8nr07188h · Cited by 166 · see citing works
Investigation of Vaporized Submicron Perfluorocarbon Droplets as an Ultrasound Contrast Agent
Reznik, N., Williams, R., & Burns, P. N. (2011) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2011.05.001 · Cited by 158 · see citing works
Zhu, J. X., Chu, C., Li, D., Pang, X., Zheng, H., Wang, J., Shi, Y., Zhang, Y., Cheng, Y., Ren, E., et al. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201904056 · Cited by 156 · see citing works
Vaporization of perfluorocarbon droplets using optical irradiation
Strohm, E. M., Rui, M., Gorelikov, I., Matsuura, N., & Kolios, M. C. (2011) · Biomedical Optics Express · doi:10.1364/boe.2.001432 · Cited by 152 · see citing works
Global, in situ, site-specific analysis of protein S-sulfenylation
Yang, J. H., Gupta, V., Tallman, K. A., Porter, N. A., Carroll, K. S., & Liebler, D. C. (2015) · Nature Protocols · doi:10.1038/nprot.2015.062 · Cited by 139 · see citing works
Microgel Translocation through Pores under Confinement
Hendrickson, G. R., & Lyon, L. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200906606 · Cited by 128 · see citing works
Streeter, J. E., Gessner, R. C., Miles, I., & Dayton, P. A. (2010) · Molecular Imaging · doi:10.2310/7290.2010.00005 · Cited by 127 · see citing works
Dietrich, C. F., Lorentzen, T., Appelbaum, L., Buscarini, E., Cantisani, V., Corréas, J.-M., Cui, X., D’Onofrio, M., Gilja, O. H., Hocke, M., et al. (2016) · Ultraschall in der Medizin - European Journal of Ultrasound · doi:10.1055/s-0035-1553965 · Cited by 124 · see citing works
Self-citationTumor Physiology and Delivery of Nanopharmaceuticals
Campbell, R. B. (2006) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152006778699077 · Cited by 122 · see citing works
Functional mesoporous silica nanoparticles for bio‐imaging applications
Cha, B. G., & Kim, J. (2018) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1515 · Cited by 122 · see citing works
Nanosonosensitizers for Highly Efficient Sonodynamic Cancer Theranostics
Huang, J., Liu, F., Han, X., Zhang, L., Hu, Z., Jiang, Q., Wang, Z., Ran, H., Wang, D., & Li, P. (2018) · Theranostics · doi:10.7150/thno.29569 · Cited by 119 · see citing works
Self-citationLi, W., Rong, P., Yang, K., Huang, P., Sun, K., & Chen, X. S. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.12.037 · Cited by 112 · see citing works
You, Y., Wang, Z., Ran, H., Zheng, Y., Wang, D., Xu, J., Wang, Z., Chen, Y., & Li, P. (2016) · Nanoscale · doi:10.1039/c5nr08292g · Cited by 109 · see citing works
Self-citationToward in vivo detection of hydrogen peroxide with ultrasound molecular imaging
Olson, E. S., Orozco, J., Wu, Z. B., Malone, C. D., Yi, B.-H., Gao, W. F., Eghtedari, M., Wang, J., & Mattrey, R. F. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.06.055 · Cited by 106 · see citing works
Chen, Y., Liu, T.-Y., Chang, P., Hsu, P., Liu, H.-L., Lin, H., & Chen, S. (2016) · Nanoscale · doi:10.1039/c5nr07782f · Cited by 106 · see citing works
Niu, D., Wang, X., Li, Y., Zheng, Y., Li, F., Chen, H., Gu, J., Zhao, W., & Shi, J. (2013) · Advanced Materials · doi:10.1002/adma.201204316 · Cited by 105 · see citing works
Acoustically modulated magnetic resonance imaging of gas-filled protein nanostructures
Lu, G. J., Farhadi, A., Szablowski, J. O., Lee‐Gosselin, A., Barnes, S. R., Lakshmanan, A., Bourdeau, R. W., & Shapiro, M. G. (2018) · Nature Materials · doi:10.1038/s41563-018-0023-7 · Cited by 103 · see citing works
Zhao, Y., Song, W., Wang, D., Ran, H., Wang, R., Yao, Y., Wang, Z., Zheng, Y., & Li, P. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b01873 · Cited by 102 · see citing works
Self-citationUltrasound responsive mesoporous silica nanoparticles for biomedical applications
Manzano, M., & Vallet‐Regí, M. (2019) · Chemical Communications · doi:10.1039/c8cc09389j · Cited by 100 · see citing works
Xu, H., Yang, J., ZhuGe, D., Lin, M., Zhu, Q., Jin, B., Tong, M., Shen, B., Xiao, J., & Zhao, Y. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701130 · Cited by 98 · see citing works
Wang, J., Liu, L., You, Q., Song, Y., Sun, Q., Wang, Y., Cheng, Y. S., Tan, F., & Li, N. (2018) · Theranostics · doi:10.7150/thno.22325 · Cited by 96 · see citing works
Papachristodoulou, A., Signorell, R. D., Werner, B., Brambilla, D., Luciani, P., Çavuşoğlu, M., Grandjean, J., Silginer, M., Rudin, M., Martin, E., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.009 · Cited by 93 · see citing works
Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions
Lanza, G., Winter, P. M., Caruthers, S. D., Hughes, M. S., Hu, G., Schmieder, A. H., & Wickline, S. A. (2010) · Angiogenesis · doi:10.1007/s10456-010-9166-0 · Cited by 91 · see citing works
A single-step multi-level supramolecular system for cancer sonotheranostics
Lin, H., Li, S., Wang, J., Chu, C., Zhang, Y., Pang, X., Lv, P., Wang, X., Zhao, Q., Chen, J., et al. (2018) · Nanoscale Horizons · doi:10.1039/c8nh00276b · Cited by 91 · see citing works
Bohndiek, S. E., Sasportas, L. S., Machtaler, S., Jokerst, J. V., Hori, S. S., & Gambhir, S. S. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.160002 · Cited by 88 · see citing works
Casciaro, S., Conversano, F., Ragusa, A., Malvindi, M. A., Franchini, R., Greco, A., Pellegrino, T., & Gigli, G. (2010) · Investigative Radiology · doi:10.1097/rli.0b013e3181e6f42f · Cited by 87 · see citing works
Protein-based photothermal theranostics for imaging-guided cancer therapy
Rong, P., Huang, P., Liu, Z., Lin, J., Jin, A. J., Ma, Y., Niu, G., Yu, L., Zeng, W., Wang, W., et al. (2015) · Nanoscale · doi:10.1039/c5nr04428f · Cited by 86 · see citing works
Devarakonda, S. B., Myers, M. R., Lanier, M., Dumoulin, C. L., & Banerjee, R. K. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b00272 · Cited by 85 · see citing works
Nanoparticles prepared from porous silicon nanowires for bio-imaging and sonodynamic therapy
Osminkina, L. A., Sivakov, V. A., Mysov, G. A., Georgobiani, V. A., Natashina, U. A., Talkenberg, F., Solovyev, V. V., Kudryavtsev, A. L., & Timoshenko, V. Y. (2014) · Nanoscale Research Letters · doi:10.1186/1556-276x-9-463 · Cited by 80 · see citing works
Wang, X., Wang, W., Yu, L., Tang, Y., Cao, J., & Chen, Y. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00938k · Cited by 79 · see citing works
Liu, J., Xu, F., Huang, J., Xu, J., Liu, Y., Yao, Y., Ao, M., Li, A., Hao, L., Cao, Y., et al. (2018) · Biomaterials Science · doi:10.1039/c8bm00726h · Cited by 68 · see citing works
Self-citationBharathiraja, S., Manivasagan, P., Santhamoorthy, M., Bui, N. Q., Jang, B., Phan, T. T. V., Jung, W., Kim, Y.-M., Lee, K. D., & Oh, J. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.11.007 · Cited by 66 · see citing works
Paris, J. L., de la Torre, P., Cabañas, M. V., Manzano, M., Grau, M., Flores, A. I., & Vallet‐Regí, M. (2017) · Nanoscale · doi:10.1039/c7nr01070b · Cited by 65 · see citing works
Double-scattering/reflection in a Single Nanoparticle for Intensified Ultrasound Imaging
Zhang, K., Chen, H., Guo, X., Zhang, D., Zheng, Y., Zheng, H., & Shi, J. (2015) · Scientific Reports · doi:10.1038/srep08766 · Cited by 63 · see citing works
Nanobiotechnology Promotes Noninvasive High‐Intensity Focused Ultrasound Cancer Surgery
Chen, Y., Chen, H., & Shi, J. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400127 · Cited by 63 · see citing works
Oda, Y., Suzuki, R., Otake, S., 功人, 西., Hirata, K., Koshima, R., Nomura, T., Utoguchi, N., Kudo, N., Tachibana, K., et al. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.003 · Cited by 61 · see citing works
Teng, Z., Wang, R., Zhou, Y., Kolios, M. C., Wang, Y., Zhang, N., Wang, Z., Zheng, Y., & Lu, G. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.021 · Cited by 57 · see citing works
Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents
Liberman, A., Wang, J., Lü, N., Viveros, R. D., Allen, C. A., Mattrey, R. F., Blair, S. L., Trogler, W. C., Kim, M. J., & Kummel, A. C. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201500610 · Cited by 51 · see citing works
Huang, Y.-K., Su, C., Chen, J.-J., Chang, C.-T., Tsai, Y.-H., Syu, S.-F., Tseng, T.-T., & Yeh, C. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b04759 · Cited by 38 · see citing works
Ray, A., Mukundan, A., Xie, Z., Karamchand, L., Wang, X., & Kopelman, R. (2014) · Nanotechnology · doi:10.1088/0957-4484/25/44/445104 · Cited by 31 · see citing works
Xu, H., Fan, Z.-L., Zhuge, D., Shen, B., Jin, B., Xiao, J., Lu, C., & Zhao, Y. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.07.019 · Cited by 30 · see citing works
Characterization of HIFU transducers designed for sonochemistry application: Acoustic streaming
Hallez, L., Touyeras, F., Hihn, J., & Bailly, Y. (2015) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2015.10.019 · Cited by 26 · see citing works
Rojas, J. D., & Dayton, P. A. (2018) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2018.08.017 · Cited by 25 · see citing works
Zhang, K., Chen, H., Li, P., Bo, X., Li, X., Zeng, Z., & Xu, H. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b04999 · Cited by 24 · see citing works
Self-citationTrendowski, M. R., Wong, V., Zoino, J. N., Christen, T. D., Gadeberg, L., Sansky, M., & Fondy, T. P. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.02.001 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Strategies for enhancing cancer chemodynamic therapy performance
Jana, D., & Zhao, Y. (2022) · Exploration · doi:10.1002/exp.20210238 · Cited by 288 · see citing works
Nanocatalyst‐Mediated Chemodynamic Tumor Therapy
Zhang, L., Li, C., Wan, S., & Zhang, X. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101971 · Cited by 265 · see citing works
Responsive biomaterials: optimizing control of cancer immunotherapy
Xue, L., Thatte, A. S., Mai, D., Haley, R. M., Gong, N., Han, X., Wang, K., Sheppard, N. C., June, C. H., & Mitchell, M. J. (2023) · Nature Reviews Materials · doi:10.1038/s41578-023-00617-2 · Cited by 217 · see citing works
“Despite their non-invasive nature, attaining precise spatial governance over ultrasound waves within complex biological systems can pose a challenge 135 .”
BackgroundSonodynamic therapy-derived multimodal synergistic cancer therapy
Xu, M., Zhou, L., Zheng, L., Zhou, Q., Liu, K., Mao, Y., & Song, S. (2021) · Cancer Letters · doi:10.1016/j.canlet.2020.10.037 · Cited by 211 · see citing works
Self-citationUltrasound‐controlled drug release and drug activation for cancer therapy
Tu, L., Liao, Z., Luo, Z., Wu, Y., Herrmann, A. P., & Huo, S. (2021) · Exploration · doi:10.1002/exp.20210023 · Cited by 197 · see citing works
Ultrasound-Based Micro-/Nanosystems for Biomedical Applications
Huang, H. F., Zheng, Y., Chang, M., Song, J., Xia, L., Wu, C., Jia, W., Ren, H., Feng, W., & Chen, Y. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00009 · Cited by 186 · see citing works
Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions
Kashkooli, F. M., Jakhmola, A., Hornsby, T. K., Tavakkoli, J., & Kolios, M. C. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.02.009 · Cited by 182 · see citing works
Metal-free bioorthogonal click chemistry in cancer theranostics
Wu, D., Yang, K., Zhang, Z., Feng, Y., Rao, L., Chen, X. S., & Yu, G. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00451d · Cited by 177 · see citing works
Siafaka, P. I., Okur, N. Ü., Karantas, I. D., Okur, M. E., & Gündoğdu, E. (2020) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2020.03.003 · Cited by 170 · see citing works
Therapeutic oxygen delivery by perfluorocarbon-based colloids
Krafft, M. P., & Riess, J. G. (2021) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2021.102407 · Cited by 119 · see citing works
Targeting regulated cell death in tumor nanomedicines
Zeng, Q., Ma, X., Song, Y., Chen, Q., Jiao, Q., & Zhou, L. (2021) · Theranostics · doi:10.7150/thno.67932 · Cited by 118 · see citing works
“As described, the most critical mechanism by which SDT inhibits tumors is ROS-induced oxidative stress damage [64].”
BackgroundSelf-citationCuproptosis: mechanisms and nanotherapeutic strategies in cancer and beyond
Mao, L., Lu, J., Wen, X., Song, Z., Sun, C., Zhao, Y., Huang, F., Chen, S., Jiang, D., Che, W., et al. (2025) · Chemical Society Reviews · doi:10.1039/d5cs00083a · Cited by 102 · see citing works
Targeting ferroptosis synergistically sensitizes apoptotic sonodynamic anti-tumor nanotherapy
Zhou, L., Dong, C., Ding, L., Feng, W., Yu, L., Cui, X., & Chen, Y. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101212 · Cited by 95 · see citing works
Self-citationWu, H., Tong, L., Wang, Y., Yan, H., & Sun, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.646626 · Cited by 90 · see citing works
Tang, F., Ding, A., Xu, Y., Ye, Y., Li, L., Xie, R., & Huang, W. (2023) · Small · doi:10.1002/smll.202307078 · Cited by 84 · see citing works
Simultaneous photoacoustic and ultrasound imaging: A review
Yu, Y., Feng, T., Qiu, H., Gu, Y., Chen, Q., Zuo, C., & Ma, H. (2024) · Ultrasonics · doi:10.1016/j.ultras.2024.107277 · Cited by 79 · see citing works
Chen, Q., Zhang, M., Huang, H., Dong, C., Dai, X., Feng, G., Lin, L., Sun, D., Yang, D., Xie, L., et al. (2023) · Advanced Science · doi:10.1002/advs.202206244 · Cited by 83 · see citing works
Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications
Zhao, P., Deng, Y., Xiang, G., & Liu, Y. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s307885 · Cited by 74 · see citing works
Fateh, S. T., Moradi, L., Kohan, E., Hamblin, M. R., & Dezfuli, A. S. (2021) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.12.64 · Cited by 71 · see citing works
Ultrasound nanotheranostics: Toward precision medicine
Qin, Y., Geng, X., Sun, Y. L., Zhao, Y., Chai, W., Wang, X., & Wang, P. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.11.021 · Cited by 67 · see citing works
Wang, G., Jiang, Y., Xu, J., Shen, J., Lin, T., Chen, J., Fei, W., Qin, Y., Zhou, Z., Shen, Y., et al. (2022) · Advanced Materials · doi:10.1002/adma.202207271 · Cited by 69 · see citing works
Zhou, L., Feng, W., Mao, Y., Chen, Y., & Zhang, X. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.11.020 · Cited by 66 · see citing works
“medicating glutamine starvation of cancer cells, the loaded α-MT could also prevent internal GSH synthesis by limiting the entry of external glutamine, thereby cooperatively augmenting the ROS-induced cell killing efficacy [15].”
BackgroundSelf-citationLi, H., Zhang, Y., Shu, H., Lv, W., Su, C., & Nie, F. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121412 · Cited by 65 · see citing works
Recent progress of micro/nanomotors to overcome physiological barriers in the gastrointestinal tract
Zhang, S., Zhu, C., Huang, W., Liu, H., Yang, M., Zeng, X., Zhang, Z., Liu, J., Shi, J., Hu, Y., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.07.005 · Cited by 58 · see citing works
Lipid-Based Nanocarriers: Bridging Diagnosis and Cancer Therapy
Giordano, A., Provenza, A. C., Reverchon, G., Baldino, L., & Reverchon, E. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16091158 · Cited by 57 · see citing works
Tarighatnia, A., Fouladi, M. R., Nader, N. D., Aghanejad, A., & Ghadiri, H. (2022) · Materials Advances · doi:10.1039/d1ma00969a · Cited by 55 · see citing works
Hu, Z., Song, X., Ding, L., Cai, Y., Yu, L., Zhang, L., Zhou, Y., & Chen, Y. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100452 · Cited by 55 · see citing works
Nanotheranostics for Image-Guided Cancer Treatment
Dennahy, I. S., Han, Z., MacCuaig, W. M., Chalfant, H., Condacse, A., Hagood, J. M., Claros-Sorto, J. C., Razaq, W., Chakrabarty, J. H., Squires, R. A., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14050917 · Cited by 52 · see citing works
Tang, J., Zhang, X., Cheng, L., Liu, Y., Chen, Y., Jiang, Z., & Liu, J. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.12.002 · Cited by 47 · see citing works
Zha, B., Yang, J., Dang, Q., Li, P., Shi, S., Wu, J., Cui, H., Huangfu, L., Li, Y., Yang, D., et al. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04292-9 · Cited by 43 · see citing works
Self-citationExosomes and ultrasound: The future of theranostic applications
Sridharan, B., & Lim, H. G. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100556 · Cited by 41 · see citing works
“Nanotechnology has greatly contributed to development of such theranotic platform [395].”
BackgroundZhang, L., Du, X., Li, Q., Qian, L., Chen, J., Liu, C., Yu, Q., & Gan, Z. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202204629 · Cited by 40 · see citing works
Gao, H., Wang, Z., Tan, M., Liu, W., Zhang, L., Huang, J., Cao, Y., Li, P., Wang, Z., Wen, J., et al. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s336632 · Cited by 36 · see citing works
Self-citationLiposomes for Cancer Theranostics
Fernandes, D. A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102448 · Cited by 36 · see citing works
Zhao, P., Wu, T., Tian, Y., You, J. E., & Cui, X. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115323 · Cited by 39 · see citing works
Self-citationZhou, Y., Yu, L., Dong, C., Liu, J., Yang, B., Chen, Y., & Hu, Z. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.134017 · Cited by 34 · see citing works
Recent Applications of Carbon Nanomaterials for microRNA Electrochemical Sensing
Wang, J., Wen, J., & Yan, H. (2020) · Chemistry - An Asian Journal · doi:10.1002/asia.202001260 · Cited by 33 · see citing works
Yuan, G., Liu, Z., Wang, W., Liu, M., Xu, Y., Hu, W. M., Fan, Y., Zhang, X., Liu, Y., & Si, G. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01820-7 · Cited by 33 · see citing works
“Based on the unique advantages of ultrasound and nanotechnology, ultrasound nanomedicine has been regarded as a highly promising and valuable tumor-specific theragnostic methodology, which will pave a novel and efficient way for combating cancer [84, 85].”
BackgroundApoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death
Du, F., Zhao, H., Song, Y., Feng, Z., Liu, K., Wang, Z., Guo, R., Li, Q., Chen, Q., & Zhou, L. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202406150 · Cited by 32 · see citing works
Self-citationEmerging theranostics to combat cancer: a perspective on metal-based nanomaterials
Agnihotri, T. G., Gomte, S. S., & Jain, A. (2022) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2022.2153862 · Cited by 32 · see citing works
“for the diagnostic imaging in cancer owing to its ability of higher tissue penetration, and real-time analysis [63,64].”
BackgroundQin, Q., Zhou, Y., Li, P., Liu, Y., Deng, R., Tang, R., Wu, N., Wan, L., Ye, M., Zhou, H., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01885-4 · Cited by 32 · see citing works
“Acoustic droplet vaporization (ADV) is activated by ultrasound, and optical droplet vaporization (ODV) is triggered by laser [60].”
Self-citationWei, M.-J., Lai, M., Zhang, J., Pei, X., & Yan, F. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061198 · Cited by 30 · see citing works
“This might be very beneficial for image-guided drug delivery in vivo when using GVs as the gene or drug carriers [29].”
BackgroundNavigating the Clinical Landscape of Liposomal Therapeutics in Cancer Treatment
Kozak, A., Lavrih, E., Mikhaylov, G., Turk, B., & Vasiljeva, O. S. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020276 · Cited by 29 · see citing works
“…imaging [68] or a contrast agent for magnetic resonance imaging (MRI) [69], computed tomography (CT) [70], positron emission tomography (PET) [71], single-photon emission computed tomography (SPECT) [72], and photoacoustic imaging [73], or even a combination of multiple modalities [74].”
Magnetic mediators for ultrasound theranostics
Józefczak, A., Kaczmarek, K., & Bielas, R. (2021) · Theranostics · doi:10.7150/thno.62218 · Cited by 29 · see citing works
“A few review articles have already presented the potential of various materials as theranostic carriers [1, 5, 18, 19].”
BackgroundOuyang, A., Zhao, D., Wang, X., Zhang, W., Jiang, T., Li, A., & Liu, W. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb02254g · Cited by 29 · see citing works
Nitric oxide-based multi-synergistic nanomedicine: an emerging therapeutic for anticancer
Tang, Y., Li, Q., Zhou, Z., Bai, H., Xiao, N., Xie, J., & Li, C. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02929-z · Cited by 27 · see citing works
“Sonosensitizers are special compounds that can produce 1 O 2 under the action of ultrasound [204].”
BackgroundWang, H., Ding, L., Xu, F., He, L., Ye, L., Huang, L., Zhang, L., & Luo, B. (2021) · Journal of Biomaterials Applications · doi:10.1177/08853282211011766 · Cited by 26 · see citing works
The impact of low intensity ultrasound on cells: Underlying mechanisms and current status
Du, M., Li, Y., Zhang, Q., Zhang, J., Ouyang, S., & Chen, Z. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.06.004 · Cited by 25 · see citing works
Loke, Y. L., Beishenaliev, A., Wang, P., Lin, C., Chang, C.-Y., Foo, Y. Y., Faruqu, F. N., Leo, B. F., Misran, M., Chung, L. Y., et al. (2023) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2023.106437 · Cited by 25 · see citing works
“These limitations undermine the overall efficacy of SDT [13].”
BackgroundA phase I clinical trial of sonodynamic therapy combined with radiotherapy for brainstem gliomas
Huangfu, L., Zha, B., Li, P., Wang, L., Liu, X., Cui, H., Li, Y., Wu, J., Shi, S., Yang, Y., et al. (2024) · International Journal of Cancer · doi:10.1002/ijc.35218 · Cited by 24 · see citing works
Self-citationNanomaterials: a promising multimodal theranostics platform for thyroid cancer
Li, L., Wang, Z., Guo, H., & Lin, Q. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01175e · Cited by 20 · see citing works
Wang, Z., Zeng, X., Zhang, S., Li, H., Jianchao, Z., Yang, Y., Huang, W., Zhao, F., Liu, Z., Liu, J., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c07866 · Cited by 20 · see citing works
Peng, C., Chen, M., Spicer, J. B., & Jiang, X. (2021) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2021.112925 · Cited by 20 · see citing works
Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review)
Zheng, Q., Xia, B., Huang, X., Luo, J., Zhong, S., & Li, X. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.11869 · Cited by 18 · see citing works
Living Cell‐Derived Intelligent Nanobots for Precision Oncotherapy
Zhou, L., Li, K., Liu, Y., Zhang, R., Yao, Y., Chen, Q., Xie, D., & Zhang, X. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202311857 · Cited by 17 · see citing works
Self-citationLi, L., Tong, T., Ji, Q., Xu, Z., Guan, Y., Liang, X., Huang, H. W., Kang, Y., & Pang, J. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c00077 · Cited by 16 · see citing works
The investigation of oncolytic viruses in the field of cancer therapy
Yuan, Z., Zhang, Y., Wang, X., Wang, X., Ren, S., He, X., Su, J., Zheng, A., Guo, S., Chen, Y., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1423143 · Cited by 16 · see citing works
Biocompatible smart micro/nanorobots for active gastrointestinal tract drug delivery
Zhang, B., Zhu, L., Pan, H., & Cai, L. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2270915 · Cited by 12 · see citing works
“Ultrasound has been widely used in the medical field, such as ultrasound diagnosis, biosensing, and sonodynamic therapy (SDT) [95,96].”
MethodUltrasound-assisted immunotherapy for malignant tumour
Cai, X., Liu, Y., Luo, G., Yu, Z., Jiang, C., & Xu, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1547594 · Cited by 13 · see citing works
Zhang, J., Guo, T., Liu, K., Bao, K., Liu, X., Cui, S., Chen, D., Li, M. J., Bao, S., Hu, C., et al. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c02319 · Cited by 11 · see citing works
Targeted Cancer Therapy‐on‐A‐Chip
Abed, H., Radha, R., Anjum, S., Paul, V., AlSawaftah, N., Pitt, W. G., Ashammakhi, N. A., & Husseini, G. A. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400833 · Cited by 11 · see citing works
Zhao, Y., Qin, D., Chen, J., Hou, J., Ilovitsh, T., Wan, M., Wu, L., & Feng, Y. (2022) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2022.106224 · Cited by 10 · see citing works
“droplets a great potential for ultrasound theranostics [20].”
BackgroundSridharan, B., Sharma, A. K., & Lim, H. G. (2023) · Sensors · doi:10.3390/s23167290 · Cited by 10 · see citing works
“Ultrasound has a long-standing relationship with biomedical imaging of many diseases, including cancer [2], while diagnosis and therapy of cancer and pertaining adverse conditions depend on biomedical instrumentations, including ultrasound.”
BackgroundMethodSheng, D., Liu, T., Qian, L., Chen, J., Wei, Y., Chen, H., & Chang, C. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02623-0 · Cited by 9 · see citing works
Ultrasound meets nanomedicine: towards disease treatment and medical imaging
Li, X., Liu, Y., Wu, X., Huang, R., Chen, S., & Yuan, K. (2025) · Microchimica Acta · doi:10.1007/s00604-025-07042-y · Cited by 9 · see citing works
Ultrasound-induced single-electron reduction of azide groups in aromatic prodrugs
Sun, J., Yao, H., Yang, C., Xue, F., Ren, X., Cui, L., Liu, Z., Tang, Z., & Chen, X. (2025) · National Science Review · doi:10.1093/nsr/nwaf140 · Cited by 9 · see citing works
“Ultrasound (US) is widely used for tumor diagnosis and therapy due to its real-time imaging capabilities, high efficiency, portability, and deep tissue penetration without harming healthy tissues [19 – 23 ].”
New strategies for tumor diagnosis and therapy with ultrasound assisted by nanomaterials
Sang, W., Fan, H., Huang, Y., Zhang, J., Gao, W., Zhao, C., Liu, X., Zhao, L., Liu, Y., Dai, Y., et al. (2025) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2025.107542 · Cited by 9 · see citing works
“They must also effectively load and precisely release drugs under ultrasound triggers for precise treatment [11].”
InfluentialSun, L., Qi, J., Ding, L., Wang, Z., Ji, G., & Zhang, P. (2024) · Scientific Reports · doi:10.1038/s41598-024-79069-9 · Cited by 8 · see citing works
New Era on Combining Both Imaging and Drug Delivery to Treat Cancer
Siafaka, P. I., Çağlar, E. Ş., Gündoğdu, E., & Okur, N. Ü. (2022) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201023666220617152334 · Cited by 8 · see citing works
Shen, J., Wang, G., Huang, Z., Chen, J., Lin, T., Xia, F., Jiang, Y., Chen, H., Liu, Y., & Huang, P. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202405061 · Cited by 7 · see citing works
Trenker, C., Görg, C., Hollerweger, A., Jenssen, C., Dong, Y., Cui, X., & Dietrich, C. F. (2020) · Medical Ultrasonography · doi:10.11152/mu-2635 · Cited by 6 · see citing works
“metastases of renal cell cancer, neuroendocrine, thyroid, breast and ovarian cancer [16-19].”
BackgroundSelf-citationLi, X., Lin, L., Zhu, M., Li, X., Yu, J., Lu, D., Li, S., Shen, Y., Xiong, B., Zhao, C., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70771-y · Cited by 5 · see citing works
Research progress of tumor sonodynamic therapy based on nanomaterials
Chen, L., Xu, P., Wang, S., & Chen, A. (2020) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2020-1053 · Cited by 5 · see citing works
Peng, S., Cai, J., & Bao, S. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12470 · Cited by 5 · see citing works
Recent Advancement of Nanotheranostics in Cancer Applications
Parveen, S., Rajendran, A., Paikray, S. K., Sahoo, L., Tripathy, N. S., & Dilnawaz, F. (2024) · Current Drug Delivery · doi:10.2174/0115672018307617240514092110 · Cited by 5 · see citing works
Li, W., Huang, Q., Li, M., Wen, Y., Chen, Z., Fan, Y., Shen, C., Chen, G., Luo, Y., & Deng, Z. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1644007 · Cited by 4 · see citing works
Wang, Y., Liu, C., Lyu, R., & Zhang, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1670527 · Cited by 4 · see citing works
Thanjavur, N., Lakshmi, B. A., Laxmi, B., Viswanath, B., & Kim, Y. (2024) · Nanoscale · doi:10.1039/d4nr02147a · Cited by 4 · see citing works
Liu, S., Li, M., Guo, Z., & Chen, Z. (2025) · Strahlentherapie und Onkologie · doi:10.1007/s00066-025-02385-0 · Cited by 3 · see citing works
Tumor Phantom with Incorporated SERS Tags: Detectability in a Turbid Medium
Khlebtsov, B. N., Bratashov, D. N., Буров, А. М., & Khlebtsov, N. G. (2021) · Photonics · doi:10.3390/photonics8050144 · Cited by 3 · see citing works
“Existing bioimaging technologies provide various opportunities for application in oncology through different imaging modalities, such as computed X-ray tomography [1], magnetic resonance imaging [2], ultrasound [3], positron emission tomography [4], and optical imaging [5].”
BackgroundLi, J., Lu, T., He, M., Cao, S., Wang, J., Liao, X., Huang, Z., & Yin, G. (2025) · Microporous and Mesoporous Materials · doi:10.1016/j.micromeso.2025.113893 · Cited by 2 · see citing works
Liu, X., Huangfu, L., Wang, L., Ding, J., Li, T., Liu, Y., Yu, Y., Zhang, M., Dai, Z., & Zheng, Y. (2025) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2025.105296 · Cited by 2 · see citing works
Sun, J., Yao, H., & Wang, G. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.115867 · Cited by 2 · see citing works
First experiments with carbon black pigment dispersion acting as a Janus ultrasound contrast agent
Jordaan, J. D. B., Nixon, K. J., Carlson, C. S., & Postema, M. (2023) · BIO Integration · doi:10.15212/bioi-2023-0004 · Cited by 2 · see citing works
Nanoparticle Targeting Strategies In Cancer Therapy
Balyapan, H., & Ak, G. (2023) · Recent advances in biotechnology · doi:10.2174/9789815179422123080010 · Cited by 2 · see citing works
Cancer theranostics: recent global advances
Jahani, R., Mosayebnia, M., Mortazavi, S. M., Movahed, M. A., Tabatabaei, M. S., Khajeamiri, Y., Fatehi, D., & Maleksabet, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15518-5.00023-9 · Cited by 2 · see citing works
Hiwase, K., Verma, P., Zade, N. R., Kumar, P., Weerarathna, I. N., & Gundewar, S. K. (2026) · International Journal of Computational Intelligence Systems · doi:10.1007/s44196-026-01164-8 · Cited by 2 · see citing works
FeMoO y @MoS x heterostructure coated by cell membrane to promote sono/chemodynamic tumor treatment
Gan, T., Nan, J., Fang, C., Wu, Y., Li, X., Zhao, J., Fu, Y., Cai, X., & Li, X. (2025) · Nano Research · doi:10.26599/nr.2025.94907641 · Cited by 1 · see citing works
Nanoparticle-ultrasound synergy: an emerging theranostic paradigm for breast and gynecologic cancers
Yang, T., Lou, Y., & Ying, Z. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1617939 · Cited by 1 · see citing works
Nanoprecipitation-based nanomaterials and targeting strategies for cancer therapy
Mehta, M., Wang, Y., & Deng, W. (2026) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2026.102024 · Cited by 1 · see citing works
MXene Chemistries for Biomedicine: On-Body, In-Body, and Beyond
Alkaya, D., Cagliani, R., Summak, G. Y., Giro, L., Beşbinar, Ö., Alhosani, M., Pogorielov, M. V., Gupta, M., Dhingra, S., Orecchioni, M., et al. (2026) · ACS Nano · doi:10.1021/acsnano.6c05051 · Cited by 1 · see citing works
Functionalized Targeted Theranostic Nanomedicines
Ahmad, M. Z., Pathak, K., Ahmad, J., Aslam, M., Bagre, A., Patel, P. C., & Jain, K. (2023) · Springer eBooks · doi:10.1007/978-981-99-0538-6_1 · Cited by 1 · see citing works
High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix
Anderton, N., Carlson, C. S., Hu, X., Otake, N., Sorjonen, J., Kudo, N., Ketolainen, J., & Postema, M. (2023) · Current Directions in Biomedical Engineering · doi:10.1515/cdbme-2023-1007 · Cited by 1 · see citing works
Nanotechnology for Bioengineers
Zhang, W. (2020) · Synthesis lectures on biomedical engineering · doi:10.1007/978-3-031-01668-4 · Cited by 1 · see citing works
Tips and Tricks in Molecular Imaging: A Practical Approach
Tarighatnia, A., Johal, G., Aghanejad, A., Ghadiri, H., & Nader, N. D. (2021) · Frontiers in biomedical technologies · doi:10.18502/fbt.v8i3.7118 · Cited by 1 · see citing works
Nanotechnology-Based ROS-Triggered Therapeutic Strategies in Multiple Cancer
Mohanty, S., & Paul, S. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_119 · Cited by 1 · see citing works
Nanotechnology for Bioengineers
Zhang, W. (2020) · Synthesis lectures on biomedical engineering · doi:10.2200/s01031ed1v01y202007bme060
Nanotechnology-Based ROS-Triggered Therapeutic Strategies in Multiple Cancer
Mohanty, S., & Paul, S. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_119-1
Biological applications of green bionanomaterials: diagnosis applications
Zarrabi, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91195-5.00020-9
- Authors
- Zhou, L.-Q., Li, P., Cui, X.-W., & Dietrich, C. F.
- Affiliations
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Tongji Hospital (CN)
- Corresponding author
- Cui, Xin-Wu
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 470
- Pages
- 204-219
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2991352583
- Cited by
- 112
- References
- 92
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 18 · 2023: 25 · 2022: 17 · 2021: 19 · 2020: 8
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Keywords
- cancer, ultrasound molecular imaging, nanomaterials, microbubbles, structure-function relationship, tumor diagnosis, clinical translation
- MeSH terms
- Theranostic Nanomedicine, Animals, Antineoplastic Agents, Combined Modality Therapy, Contrast Media, Disease Models, Animal, Humans, Immunotherapy, Neoplasms, Ultrasonography, Ultrasonic Therapy, Microbubbles, Nanoparticles, Photoacoustic Techniques, Multimodal Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review