The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.
Immunotherapy for hepatocellular carcinoma
Open accessAbstract
Despite significant research efforts, only a few treatment approaches have been developed for hepatocellular carcinoma (HCC). In recent years, immune checkpoint inhibitors (anti-PD-1, anti-PD-L1, and anti-CTLA-4 antibodies) have exhibited potential therapeutic effects for advanced HCC. With the development of gene-editing technologies, gene-sequencing technologies, big data strategies, and artificial intelligence algorithms, engineered immune cell infusion and personalized cancer vaccine therapy have emerged as important directions for anti-HCC treatment. Combining different immunotherapies or combining immunotherapies with conventional therapeutic approaches may provide synergistic effects and facilitate the development of personalized medicine. In this study, we provide an overview of the liver immunoanatomy, the potential immune mechanisms of HCC, and current (pre)clinical developments in this field.
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1 retracted
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Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
Larkin, J., Chiarion-Sileni, V., Gonzalez, R., Grob, J. J., Cowey, C. L., Lao, C. D., Schadendorf, D., Dummer, R., Smylie, M., Rutkowski, P., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504030 · Cited by 8,157
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
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Car t cell immunotherapy for human cancer
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Mechanisms of hepatic stellate cell activation
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Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
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Cited by
Pyroptosis: Mechanisms and Diseases
Yu, P., Zhang, X., Liu, N., Tang, L., Peng, C., & Chen, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00507-5 · Cited by 2,353
Metadata
- Authors
- Zongyi, Y., & Xiaowu, L.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 470
- Pages
- 8-17
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2992211060
- Cited by
- 265
- References
- 167
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zongyi, Y., & Xiaowu, L. (2020). Immunotherapy for hepatocellular carcinoma. Cancer Letters. https://doi.org/10.1016/j.canlet.2019.12.002
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
