The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics
Abstract
Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various cancers and promoted proliferation and metastasis of tumor cells. The errant expression of PKM2 has inspired people to investigate the function of PKM2 and the therapeutic potential in cancer. In addition, some studies have shown that the upregulation of PKM2 in tumor tissues is associated with the altered expression of lncRNAs and the poor survival. Therefore, researchers have begun to unravel the specific molecular mechanisms of lncRNA-mediated PKM2 expression in cancer metabolism. As the tumor microenvironment (TME) is essential in tumor development, it is necessary to identify the role of PKM2 in TME. In this review, we will introduce the role of PKM2 in different cancers as well as TME, and summarize the molecular mechanism of PKM2-related lncRNAs in cancer metabolism. We expect that this work will lead to a better understanding of the molecular mechanisms of PKM2 that may help in developing therapeutic strategies in clinic for researchers.
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4 retracted
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Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
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Self-citationTargeting glucose metabolism enzymes in cancer treatment: current and emerging strategies
Zhang, Y., Li, Q., Huang, Z., Li, B., Nice, E. C., Huang, C., Wei, L., & Zou, B. (2022) · Cancers · doi:10.3390/cancers14194568 · Cited by 144
Chaperone‐mediated autophagy: Molecular mechanisms, biological functions, and diseases
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Metadata
- Authors
- Zhu, S., Guo, Y., Zhang, X., Liu, H., Yin, M., Chen, X., & Peng, C.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 503
- Pages
- 240-248
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W3109467285
- Cited by
- 266
- References
- 107
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhu, S., Guo, Y., Zhang, X., Liu, H., Yin, M., Chen, X., & Peng, C. (2021). Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics. Cancer Letters. https://doi.org/10.1016/j.canlet.2020.11.018
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
