Anti-inflammatory effect of fucoidan extracted from Ecklonia cava in zebrafish model
Abstract
Fucoidan extracted from Ecklonia cava had strong anti-inflammatory activities. However, the direct effects of fucoidan of E. cava on anti-inflammatory activities in vivo model remained to be determined. Therefore, the present study was designed to assess in vivo anti-inflammatory effect of fucoidan extracted from E. cava (ECF) using tail-cutting-induced and lipopolysaccharide (LPS)-stimulated zebrafish model. Treating zebrafish model with tail-cutting and LPS-treatment significantly increased the ROS and NO level. However, ECF inhibited this tail-cutting-induced and LPS-stimulated ROS and NO generation. These results show that ECF alleviated inflammation by inhibiting the ROS and NO generation induced by tail-cutting and LPS-treatment. In addition, ECF has a protective effect against the toxicity induced by LPS exposure in zebrafish embryos. This outcome could explain the potential anti-inflammatory activity of ECF, which might have a beneficial effect during the treatment of inflammatory diseases.
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Fucoidan from Chnoospora minima, Ecklonia cava, and S. horneri decreases production of COX-2 and NO in LPS-induced zebrafish embryos.
“According to a recently published study, fucoidan isolated from Chnoospora minima, Ecklonia cava, and S. horneri decreases the production of COX-2 and NO in LPS-induced zebrafish embryos [7,58,86].”
From A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent (2022) · cites this paper as [86]
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Self-citationA Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent
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Sanjeewa, K. K. A., Jayawardena, T. U., Kim, S.-Y., Kim, H.-S., Ahn, G., Kim, J., & Jeon, Y.-J. (2019) · Algal Research · doi:10.1016/j.algal.2019.101561 · Cited by 76 · see citing works
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- Authors
- Lee, S.-H., Ko, C.-I., Jee, Y., Jeong, Y., Kim, M., Kim, J.-S., & Jeon, Y.-J.
- Affiliations
- Jeju National University (KR)
- Dankook University (KR)
- Gyeongsang National University (KR)
- Corresponding author
- Jeon, You-Jin
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 92
- Issue
- 1
- Pages
- 84-89
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2011139685
- Cited by
- 184
- References
- 0
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 14 · 2023: 23 · 2022: 13 · 2021: 18 · 2020: 25 · 2019: 14 · 2018: 14 · 2017: 14 · 2016: 10 · 2015: 6 · 2014: 4 · 2013: 2
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea
- Ministry of Education, Science and Technology
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- fucoidan, Ecklonia cava, anti-inflammatory activity, zebrafish, lipopolysaccharide, reactive oxygen species, nitric oxide
- MeSH terms
- Phaeophyceae, Animals, Anti-Inflammatory Agents, Inflammation, Lipopolysaccharides, Nitric Oxide, Polysaccharides, Zebrafish
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