Microwave assisted synthesis of acrylamide grafted locust bean gum and its application in drug delivery
Abstract
Acrylamide grafted copolymer of locust bean gum was prepared by microwave irradiation using ceric ammonium nitrate as redox initiator. The grafting process was optimized in terms of irradiation time, amount of initiator and acrylamide by using constant amount of native locust bean gum. The grafted gum was characterized by Fourier transform infrared spectroscopy (FT-IR), (13)C nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), X-ray diffraction study (XRD), differential scanning calorimetry (DSC), elemental analysis, contact angle, viscosity, molecular weight, swelling and biodegradability studies. The grafted gum was found to be biodegradable and non-toxic. It was further used to prepare controlled-release matrix tablet of buflomedil hydrochloride. The in vitro release profile of the tablet showed the rate controlling property of acrylamide grafted locust bean gum was similar to that of hydroxypropyl methylcellulose (HPMC-K15M).
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The hydrogel formulation has an enhanced amorphous nature compared with the parent polymer.
“A less intense PXRD pattern of hydrogels specifies an enhanced amorphous nature of formulation as compared to the parent polymer (Kaity et al., 2013).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Kaity et al., 2013
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“A less intense PXRD pattern of hydrogels specifies an enhanced amorphous nature of formulation as compared to the parent polymer (Kaity et al., 2013).”
Background
- Authors
- Kaity, S., Isaac, J., Kumar, P. M., Bose, A., Wong, T. W., & Ghosh, A.
- Affiliations
- Birla Institute of Technology, Mesra (IN)
- Universiti Teknologi MARA System (MY)
- Corresponding author
- Ghosh, Animesh
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 98
- Issue
- 1
- Pages
- 1083-1094
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2042975020
- Cited by
- 106
- References
- 26
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 15 · 2018: 10 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 2 · 2013: 1
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- CSIR, New Delhi (09/554(0029)/2011)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- locust bean gum, acrylamide grafting, microwave-assisted synthesis, ceric ammonium nitrate, biodegradable hydrogels, controlled drug release, buflomedil hydrochloride, matrix tablets, swelling behavior, biodegradability
- MeSH terms
- Animals, Drug Carriers, Female, Galactans, Half-Life, Mannans, Microwaves, Pyrrolidines, Solubility, Viscosity, Water, Toxicity Tests, Acrylamide, Mice, Plant Gums, Chemistry Techniques, Synthetic
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