Synthesis, characterization, swelling and drug release behavior of semi-interpenetrating network hydrogels of sodium alginate and polyacrylamide
Abstract
Several semi interpenetrating network (SIPN) type hydrogels were synthesized by in-situ free radical crosslink copolymerization of acrylamide and crosslinker N,N'-methylene bisacrylamide (MBA) in aqueous solution of sodium alginate (SA).These SIPN hydrogels were characterized by FTIR, NMR SEM, DTA-TGA, XRD, PZC and also by swelling characteristics and network parameters. Adsorption (loading) and release of acetaminophen drug were studied with these hydrogels. Solution pH, crosslinker concentration and monomer to SA weight ratio of the hydrogels were found to have a strong effect on adsorption and in vitro release profile of the drug from the gel matrix.
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Monomer acrylic acid increases grafting to form a compact structure in PAG-co-AA hydrogels.
“Similarly, monomer AA also increases grafting to form compact structure (Samanta and Ray 2014).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Samanta and Ray 2014
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Design and applications of interpenetrating polymer network hydrogels. A review
Dragan, E. S. (2014) · Chemical Engineering Journal · doi:10.1016/j.cej.2014.01.065 · Cited by 992 · see citing works
Shaheen, A., Maswal, M., & Dar, A. A. (2021) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2021.127223 · Cited by 63 · see citing works
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“Similarly, monomer AA also increases grafting to form compact structure (Samanta and Ray 2014).”
BackgroundHassaninejad Farahani, F., Moraffah, F., Samadi, N., Sharifzadeh, M., Motasadizadeh, H., & Vatanara, A. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122800 · Cited by 20 · see citing works
Suhail, M., Liu, J.-Y., Hsieh, W.-C., Lin, Y.-W., Usman Minhas, M., & Wu, P.-C. (2022) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2021.103590 · Cited by 20 · see citing works
- Authors
- Samanta, H. S., & Ray, S. K.
- Affiliations
- University of Calcutta (IN)
- Corresponding author
- Ray, Samit Kumar
- ORCID
- Ray, Samit Kumar
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 99
- Pages
- 666-678
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2078963254
- Cited by
- 293
- References
- 1
- Citations by year
- 2026: 16 · 2025: 37 · 2024: 26 · 2023: 34 · 2022: 22 · 2021: 37 · 2020: 26 · 2019: 23 · 2018: 19 · 2017: 15 · 2016: 17 · 2015: 14 · 2014: 7
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of scientific and industrial research (CSIR)
- Department of Science and Technology (DST), Govt. of India
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Polymer-Based Agricultural Enhancements
- Keywords
- semi-interpenetrating network hydrogel, sodium alginate, polyacrylamide, N,N'-methylenebisacrylamide, swelling behavior, drug release, crosslinker concentration, network parameters
- MeSH terms
- Acetaminophen, Polyacrylamides, Acrylamides, Acrylic Resins, Adsorption, Alginates, Cross-Linking Reagents, Drug Carriers, Hexuronic Acids, Hydrogen-Ion Concentration, Kinetics, Microscopy, Electron, Scanning, Magnetic Resonance Spectroscopy, Spectroscopy, Fourier Transform Infrared, Hydrogels, Glucuronic Acid
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