A photo-controlled hyaluronan-based drug delivery nanosystem for cancer therapy
Abstract
In this paper, a novel photo-controlled drug-loaded nanomicelles were self-assembled by the amphiphile of hyaluronan-o-nitrobenzyl-stearyl chain (HA-NB-SC) with doxorubicin (DOX) encapsulated within the hydrophobic core. DOX-loaded HA-NB-SC nanomicelles are ∼139 nm in diameter. CD44-overexpressed HeLa cells can easily take up HA-NB-SC micelles through recognition of HA moiety. DOX-loaded HA-NB-SC nanomicelles could be disassembled upon UV light (365 nm) and consequently, release DOX at desired pathological sites. Furtherly, nitrosobenzaldehyde derivative, photo-induced products of HA-NB-SC and DOX could inhibit the proliferation of HeLa cells together. This strategy may shed some light on delivery of hydrophobic anti-cancer drugs in a controlled manner.
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The diameter of DOX-loaded nanomicelles was determined to be ~139 nm.
“The diameter of DOX-loaded nanomicelles was determined to be ~139 nm.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [201]
The release of DOX from the developed nanomicelles at targeted sites could be taken apart upon UV light (365 nm).
“The release of DOX from the developed nanomicelles at targeted sites could be taken apart upon UV light (365 nm).”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [201]
The HA-NB-SC nanomicelles can be easily taken up by HeLa cells and could inhibit the proliferation via recognition of the HA unit.
“The results displayed that the HA-NB-SC nanomicelles can be easily taken up by HeLa cells and could inhibit the proliferation via recognition of the HA unit.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [201]
A novel amphiphile of hyaluronan-o-nitrobenzyl-stearyl was self-assembled into nanomicelles (HA-NB-SC) and doxorubicin (DOX) encapsulated within the core.
“In some studies, a novel amphiphile of hyaluronan-o-nitrobenzyl-stearyl was self-assembled into nanomicelles (HA-NB-SC) and doxorubicin (DOX) encapsulated within the core [201].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [201]
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Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
“In some studies, a novel amphiphile of hyaluronan-o-nitrobenzyl-stearyl was self-assembled into nanomicelles (HA-NB-SC) and doxorubicin (DOX) encapsulated within the core [201].”
BackgroundPhoto-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications
Hou, W., Liu, R., Bi, S., He, Q., Wang, H., & Gu, J. (2020) · Molecules · doi:10.3390/molecules25215147 · Cited by 46 · see citing works
- Authors
- Sun, F., Zhang, P., Liu, Y., Lu, C., Qiu, Y., Mu, H., & Duan, J.
- Affiliations
- Northwest A&F University (CN)
- Corresponding author
- Duan, Jinyou
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 206
- Pages
- 309-318
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2900235094
- Cited by
- 39
- References
- 43
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 10 · 2019: 4
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31570799, 31870799)
- Fundamental Research Funds for the Central Universities (2452017026)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- hyaluronic acid, nanomicelles, doxorubicin, nitrobenzyl protecting group, amphiphile self-assembly, CD44 targeting, HeLa cells, cancer therapy
- MeSH terms
- Antineoplastic Agents, Doxorubicin, Drug Carriers, HeLa Cells, Humans, Hyaluronic Acid, Light, Micelles, Nitrobenzoates, Particle Size, Surface-Active Agents, Nanostructures, HEK293 Cells, Drug Liberation
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