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Fabricating alginate/poly (caprolactone) nanofibers with enhanced bio-mechanical properties via cellulose nanocrystal incorporation
Abstract
In this research, cellulose nanocrystal (CNC) was synthesized from cotton waste using controlled hydrolysis against 64 % (w/w) sulfuric acid solution. The produced nanoparticles were then characterized using FTIR, XRD, TGA, and DLS analyses. Biaxial electrospinning technique was used to produce CNC incorporated PCL-PVA/NaAlg nanofibers. The sodium alginate portion was then crosslinked via submerging the samples in calcium chloride aqueous solution. The CNC incorporated and crosslinked sample was characterized using SEM, FTIR, and TGA techniques. Results confirmed the presence of CNC nanoparticles and alginate crosslinking reaction. Mechanical studies showed that CNC incorporation increases the tensile modulus by 65 %. Also, the crosslinked samples exhibited an increase in elongation at break. Water contact angle studies suggested that CNC incorporation and crosslinking improves nanofiber hydrophilicity. Cell viability of more than 90 % was observed in CNC incorporated PCL-CaAlg nanofibers. Also, SEM images of cells on nanofiber scaffolds showed better cell growth and attachment in PCL-CaAlg-CNC samples.
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“Similarly, PCL-based systems exhibited increased stiffness and biodegradation rate [20,21,22], especially when surface-modified NC is used to improve interfacial adhesion with the more hydrophobic PCL matrix [23]”
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“solution/solvent casting, often using chloroform or dichloromethane as solvents, facilitates better initial dispersion but is limited by environmental and processing drawbacks [20,22,23,36,67,68]”
Citations
Cites
Use of electrospinning technique for biomedical applications
Agarwal, S., Wendorff, J. H., & Greiner, A. (2008) · Polymer · doi:10.1016/j.polymer.2008.09.014 · Cited by 1,825
Nanocellulose: a new ageless bionanomaterial
Dufresne, A. (2013) · Materials Today · doi:10.1016/j.mattod.2013.06.004 · Cited by 1,704
Synthesis of polycaprolactone: A review
Labet, M., & Thielemans, W. (2009) · Chemical Society Reviews · doi:10.1039/b820162p · Cited by 1,673
Potential of Nanofiber Matrix as Tissue-Engineering Scaffolds
Ma, Z., Kotaki, M., Inai, R., & Ramakrishna, S. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.101 · Cited by 1,044
Preparation and properties of cellulose nanocrystals: Rods, spheres, and network
Lü, P., & Hsieh, Y. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.04.073 · Cited by 992
Jonoobi, M., Oladi, R., Davoudpour, Y., Oksman, K., Dufresne, A., Hamzeh, Y., & Davoodi, R. (2015) · Cellulose · doi:10.1007/s10570-015-0551-0 · Cited by 883
Alginate-based composites for environmental applications: a critical review
Wang, B., Wan, Y., Zheng, Y., Lee, X., Liu, T., Yu, Z., Huang, J. G., Ok, Y. S., Chen, J., & Gao, B. (2018) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2018.1547621 · Cited by 523
FT-IR spectra of alginic acid block fractions in three species of brown seaweeds
Leal, D., Matsuhiro, B., Rossi, M., & Caruso, F. (2007) · Carbohydrate Research · doi:10.1016/j.carres.2007.10.016 · Cited by 471
Versatile Application of Nanocellulose: From Industry to Skin Tissue Engineering and Wound Healing
Bačáková, L., Pajorová, J., Bačáková, M., Skogberg, A., Kallio, P. J., Kolářová, K., & Švorčı́k, V. (2019) · Nanomaterials · doi:10.3390/nano9020164 · Cited by 424
Evaluation of sodium alginate for bone marrow cell tissue engineering
Wang, L., Shelton, R. M., Cooper, P. R., Lawson, M. A., Triffitt, J. T., & Barralet, J. E. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00167-4 · Cited by 362
Effect of Cross-Linking with Calcium Ions on the Physical Properties of Alginate Films
Russo, R., Malinconico, M., & Santagata, G. (2007) · Biomacromolecules · doi:10.1021/bm700565h · Cited by 322
Sugarcane bagasse whiskers: Extraction and characterizations
Teixeira, E. D. M., Bondancia, T. J., Teodoro, K. B. R., Corrêa, A. C., Marconcini, J. M., & Mattoso, L. H. C. (2010) · Industrial Crops and Products · doi:10.1016/j.indcrop.2010.08.009 · Cited by 308
Rusli, R., & Eichhorn, S. J. (2008) · Applied Physics Letters · doi:10.1063/1.2963491 · Cited by 293
Bonino, C. A., Krebs, M. D., Saquing, C. D., Jeong, S. I., Shearer, K. L., Alsberg, E., & Khan, S. A. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.02.002 · Cited by 289
Yin, O. S., Ahmad, I. B., & Amin, M. C. I. M. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.11.082 · Cited by 275
Hajiali, F., Tajbakhsh, S., & Shojaei, A. (2017) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583724.2017.1332640 · Cited by 267
Islam, M. S., & Karim, M. R. (2010) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2010.05.038 · Cited by 258
Reinforcing Poly(ε-caprolactone) Nanofibers with Cellulose Nanocrystals
Zoppe, J. O., Peresin, M. S., Habibi, Y., Venditti, R. A., & Rojas, O. J. (2009) · ACS Applied Materials & Interfaces · doi:10.1021/am9003705 · Cited by 248
Shi, Q., Zhou, C., Yue, Y., Guo, W., Wu, Y., & Wu, Q. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.05.042 · Cited by 229
Multiwall carbon nanotubes/polycaprolactone composites for bone tissue engineering application
Pan, L., Pei, X., He, R., Wan, Q., & Wang, J. (2012) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2012.01.011 · Cited by 216
Loh, E. Y. X., Mohamad, N., Fauzi, M. B., Ng, M. H., Ng, S. F., & Amin, M. C. I. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-21174-7 · Cited by 208
Poly(ε-caprolactone)/graphene oxide biocomposites: mechanical properties and bioactivity
Wan, C., & Chen, B. (2011) · Biomedical Materials · doi:10.1088/1748-6041/6/5/055010 · Cited by 205
Kumar, A., Lee, Y., Kim, D., Rao, K. M., Kim, J., Park, S., Haider, A., Lee, D. H., & Han, S. S. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.10.085 · Cited by 202
Alginate Based Scaffolds for Cartilage Tissue Engineering: A Review
Farokhi, M., Shariatzadeh, F. J., Solouk, A., & Mirzadeh, H. (2019) · International Journal of Polymeric Materials · doi:10.1080/00914037.2018.1562924 · Cited by 196
Wang, L.-F., Shankar, S., & Rhim, J. (2016) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.08.041 · Cited by 195
Joseph, B., Augustine, R., Kalarikkal, N., Thomas, S., Seantier, B., & Grohens, Y. (2019) · Materials Today Communications · doi:10.1016/j.mtcomm.2019.02.009 · Cited by 189
Adeli‐Sardou, M., Yaghoobi, M. M., Torkzadeh‐Mahani, M., & Dodel, M. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.237 · Cited by 186
Bacterial alginate production: an overview of its biosynthesis and potential industrial production
Urtuvia, V., Maturana, N., Acevedo, F., Peña, C., & Díaz‐Barrera, A. (2017) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-017-2363-x · Cited by 184
Zhang, C., Salick, M. R., Cordie, T. M., Ellingham, T., Dan, Y., & Turng, L. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.01.024 · Cited by 173
Zhang, J., Ji, Q., Shen, X., Xia, Y., Tan, L., & Kong, Q. (2011) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2011.01.029 · Cited by 170
Cross-linked cellulose nanocrystal aerogels as viable bone tissue scaffolds
Osorio, D. A., Lee, B. E. J., Kwiecień, J. M., Wang, X., Shahid, I., Hurley, A. L., Cranston, E. D., & Grandfield, K. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.01.049 · Cited by 165
Three-dimensional electrospun polycaprolactone (PCL)/alginate hybrid composite scaffolds
Kim, M. S., & Kim, G. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.08.008 · Cited by 159
Rheological properties of cellulose nanocrystal-embedded polymer composites: a review
Ching, Y. C., Ali, M. E., Abdullah, L. C., Choo, K. W., Kuan, Y. C., Julaihi, S. J., Chuah, C. H., & Liou, N.-S. (2016) · Cellulose · doi:10.1007/s10570-016-0868-3 · Cited by 154
A Review on Grafting of Biofibers for Biocomposites
Wei, L., & McDonald, A. G. (2016) · Materials · doi:10.3390/ma9040303 · Cited by 154
Electrospun polycaprolactone scaffolds for tissue engineering: a review
Janmohammadi, M., & Nourbakhsh, M. S. (2018) · International Journal of Polymeric Materials · doi:10.1080/00914037.2018.1466139 · Cited by 151
Materials for Biomedical Engineering
(2019) · Elsevier eBooks · doi:10.1016/c2017-0-04408-7 · Cited by 144
Controlled synthesis and structural stability of alginate-based nanofibers
Bhattarai, N., & Zhang, M. (2007) · Nanotechnology · doi:10.1088/0957-4484/18/45/455601 · Cited by 143
Analysis of cellulose nanocrystal rod lengths by dynamic light scattering and electron microscopy
Boluk, Y., & Danumah, C. (2013) · Journal of Nanoparticle Research · doi:10.1007/s11051-013-2174-4 · Cited by 140
Cho, S. J., Jung, S. M., Kang, M., Shin, H. S., & Youk, J. H. (2015) · Polymer · doi:10.1016/j.polymer.2015.05.037 · Cited by 136
Drug release and biodegradability of electrospun cellulose nanocrystal reinforced polycaprolactone
Hivechi, A., Bahrami, S. H., & Siegel, R. A. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.10.037 · Cited by 136
Self-citationBaghersad, S., Bahrami, S. H., Ranjbar‐Mohammadi, M., Mojtahedi, M. R. M., & Milan, P. B. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.08.020 · Cited by 132
Self-citationZarekhalili, Z., Bahrami, S. H., Ranjbar‐Mohammadi, M., & Milan, P. B. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.10.042 · Cited by 129
Self-citationBionanocomposites based on gelatin matrix and nanocellulose
Mondragón, G., Peña-Rodríguez, C., González, A., Eceiza, A., & Arbelaiz, A. (2014) · European Polymer Journal · doi:10.1016/j.eurpolymj.2014.11.003 · Cited by 125
Xu, W., Renzhe, S., Yan, Y., & Gao, J. (2016) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2016.09.012 · Cited by 122
Zhang, X., Chen, Y., Han, J., Mo, J., Dong, P., Zhuo, Y.-H., & Feng, Y. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.06.172 · Cited by 120
Optimized extraction of cellulose nanocrystals from pristine and carded hemp fibres
Luzi, F., Fortunati, E., Puglia, D., Lavorgna, M., Santulli, C., Kenny, J. M., & Torre, L. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.03.006 · Cited by 116
Kim, Y. B., & Kim, G. (2014) · ACS Combinatorial Science · doi:10.1021/co500033h · Cited by 105
Nazeer, M. A., Yılgör, E., & Yılgör, İ. (2019) · Polymer · doi:10.1016/j.polymer.2019.02.023 · Cited by 105
Heidari, M., Bahrami, S. H., & Ranjbar‐Mohammadi, M. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.04.095 · Cited by 102
Self-citationAlginate based scaffolds for bone tissue engineering
Valente, J. F. A., Valente, T., Alves, P., Ferreira, P. C. N., da Silva, A. V., & Correia, I. J. (2012) · Materials Science and Engineering C · doi:10.1016/j.msec.2012.08.001 · Cited by 101
Pan, Y., Wang, W., Liu, L., Ge, H., Song, L., & Hu, Y. Z. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.04.065 · Cited by 101
Boujemaoui, A., Sánchez, C. C., Engström, J., Bruce, C., Fogelström, L., Carlmark, A., & Malmström, E. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b09009 · Cited by 94
Cell proliferation on PVA/sodium alginate and PVA/poly(γ-glutamic acid) electrospun fiber
Yang, J., Yang, J. H., Tsou, S. C., Ding, C. H., Hsu, C. C., Yang, K. C., Chen, S.-W., Chen, K.-S., Chen, S.-W., & Wang, J. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.04.068 · Cited by 92
Zahedi, E., Esmaeili, A., Eslahi, N., Shokrgozar, M. A., & Simchi, A. (2019) · Marine Drugs · doi:10.3390/md17010027 · Cited by 92
Adhikari, U., An, X., Rijal, N. P., Hopkins, T., Khanal, S., Chavez, T., Tatu, R. R., Sankar, J., Little, K. J., Hom, D. B., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.04.061 · Cited by 91
Applications of Nanocomposite Materials in Dentistry
(2018) · Elsevier eBooks · doi:10.1016/c2016-0-05060-x · Cited by 91
Gao, H., Zhong, Z., Xia, H., Hu, Q., Ye, Q., Wang, Y., Chen, L., Du, Y., Shi, X., & Zhang, L. (2019) · Biomaterials Science · doi:10.1039/c9bm00288j · Cited by 85
Pathak, T. S., Yun, J., Lee, J., & Paeng, K. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.03.025 · Cited by 81
Preparation and Characterization of Blend Films of Poly(Vinyl Alcohol) and Sodium Alginate
Çaykara, T., & Demirci, S. (2006) · Journal of Macromolecular Science Part A · doi:10.1080/10601320600740389 · Cited by 77
Han, X., Huo, P., Ding, Z., Kumar, P., & Liu, B. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11090449 · Cited by 67
Effect of calcium alginate concentration on viability and proliferation of encapsulated fibroblasts
Bohari, S. P. M., Hukins, D. W. L., & Grover, L. M. (2011) · Bio-Medical Materials and Engineering · doi:10.3233/bme-2011-0665 · Cited by 66
Shoba, E., Lakra, R., Kiran, M. S., & Korrapati, P. S. (2017) · Biomedical Materials · doi:10.1088/1748-605x/aa6684 · Cited by 65
Mirtič, J., Balažic, H., Zupančič, Š., & Kristl, J. (2019) · Polymers · doi:10.3390/polym11040692 · Cited by 65
Luo, W., Cheng, L., Yuan, C., Wu, Z., Yuan, G., Hou, M., Chen, J. Y., Luo, C., & Li, W. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.05.052 · Cited by 65
Shanmugarajah, B., Kiew, P. L., Chew, I. M. L., Choong, T. S. Y., & Tan, K. W. (2015) · Chemical engineering transactions · doi:10.3303/cet1545285 · Cited by 61
Preparation of sodium alginate/poly(ethylene oxide) blend nanofibers with lecithin
Park, S. A., Park, K. E., & Kim, W. D. (2010) · Macromolecular Research · doi:10.1007/s13233-010-0909-y · Cited by 60
Tabasum, S., Noreen, A., Kanwal, A., Zuber, M., Anjum, M. N., & Zia, K. M. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.01.078 · Cited by 56
Amirabad, L. M., Jonoobi, M., Mousavi, N. S., Oksman, K., Kaboorani, A., & Yousefi, H. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.02.041 · Cited by 50
Hwang, T. I., Kim, J. I., Joshi, M. K., Park, C. H., & Kim, C. S. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.01.085 · Cited by 49
Abdal‐hay, A., Taha, M., Mousa, H. M., Bartnikowski, M., Hassan, M. L., Dewidar, M., & Ivanovski, S. (2019) · Ceramics International · doi:10.1016/j.ceramint.2019.04.206 · Cited by 37
Electrochemical characterization of PVA/SA nanofibers obtained by electrospinning processing
Covelo, A., Gómez-Lizárraga, K. K., Corona-Lira, M. P., Ramírez-Reivich, A. C., & Hernández, M. Á. (2018) · Surface and Interface Analysis · doi:10.1002/sia.6412 · Cited by 21
Hivechi, A., Bahrami, S. H., & Akerdi, A. G. (2018) · Journal of the Textile Institute · doi:10.1080/00405000.2018.1469213 · Cited by 13
Self-citationSun, K., Liu, Z., Liu, C., Yu, T., Zhou, M., Liu, C., Ran, F., Pan, L., & Zhang, H. (2016) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33731 · Cited by 10
Carbon nanocomposites for implant dentistry and bone tissue engineering
Madanagopal, T. T., Agarwalla, S. V., & Rosa, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813742-0.00003-1 · Cited by 10
Research works printed but not linked: 3
- Hivechi, 2019, Drug release and biodegradability of electrospun cellulose nanocrystal reinforced polycaprolactone, Materials Science and Engineering: C, 94, 929
- Murdzheva, 2016, Microwave-assisted synthesis of methyl esters of alginic acids as potential drug carrier, International Journal of Pharmaceutical and Clinical Research, 8, 1361
- Oprea, 2019, Chapter 4 - Electrospun nanofibers for tissue engineering applications, 77
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Structural and Functional Design of Electrospun Nanofibers for Hemostasis and Wound Healing
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Cellulose nanocrystals: Fundamentals and biomedical applications
Mali, P., & Sherje, A. P. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118668 · Cited by 244
Iacob, A.-T., Drăgan, M., Ionescu, O.-M., Profire, L., Ficai, A., Andronescu, E., Confederat, L. G., & Lupașcu, D. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100983 · Cited by 190
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Metadata
- Authors
- Rashtchian, M., Hivechi, A., Bahrami, S. H., Milan, P. B., & Simorgh, S.
- Affiliations
- Amirkabir University of Technology (IR)
- Iran University of Medical Sciences (IR)
- Corresponding author
- Hivechi, Ahmad
- Bahrami, S. Hajir
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 233
- Pages
- 115873
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2998955581
- Cited by
- 112
- References
- 74
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 18 · 2023: 8 · 2022: 30 · 2021: 25 · 2020: 5
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Advanced Cellulose Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- cellulose nanocrystals, alginate, polycaprolactone, polyvinyl alcohol, nanofibers, electrospinning, mechanical properties, hydrophilicity, cell viability, cell attachment, cotton waste, hydrolysis, scaffolds
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