The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Fabricating alginate/poly (caprolactone) nanofibers with enhanced bio-mechanical properties via cellulose nanocrystal incorporation
Abstract
In this research, cellulose nanocrystal (CNC) was synthesized from cotton waste using controlled hydrolysis against 64 % (w/w) sulfuric acid solution. The produced nanoparticles were then characterized using FTIR, XRD, TGA, and DLS analyses. Biaxial electrospinning technique was used to produce CNC incorporated PCL-PVA/NaAlg nanofibers. The sodium alginate portion was then crosslinked via submerging the samples in calcium chloride aqueous solution. The CNC incorporated and crosslinked sample was characterized using SEM, FTIR, and TGA techniques. Results confirmed the presence of CNC nanoparticles and alginate crosslinking reaction. Mechanical studies showed that CNC incorporation increases the tensile modulus by 65 %. Also, the crosslinked samples exhibited an increase in elongation at break. Water contact angle studies suggested that CNC incorporation and crosslinking improves nanofiber hydrophilicity. Cell viability of more than 90 % was observed in CNC incorporated PCL-CaAlg nanofibers. Also, SEM images of cells on nanofiber scaffolds showed better cell growth and attachment in PCL-CaAlg-CNC samples.
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“Similarly, PCL-based systems exhibited increased stiffness and biodegradation rate [20,21,22], especially when surface-modified NC is used to improve interfacial adhesion with the more hydrophobic PCL matrix [23]”
In the citing paper
“solution/solvent casting, often using chloroform or dichloromethane as solvents, facilitates better initial dispersion but is limited by environmental and processing drawbacks [20,22,23,36,67,68]”
Citations
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Cited by
Sorted by citations
Yuan, J. T., Lei, X., Yi, C., Jiang, H., Liu, F., & Cheng, G. J. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.132765 · Cited by 296
Structural and Functional Design of Electrospun Nanofibers for Hemostasis and Wound Healing
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Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing
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Metadata
- Authors
- Rashtchian, M., Hivechi, A., Bahrami, S. H., Milan, P. B., & Simorgh, S.
- Affiliations
- Amirkabir University of Technology (IR)
- Iran University of Medical Sciences (IR)
- Corresponding author
- Hivechi, Ahmad
- Bahrami, S. Hajir
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 233
- Pages
- 115873
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2998955581
- Cited by
- 112
- References
- 74
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 18 · 2023: 8 · 2022: 30 · 2021: 25 · 2020: 5
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Advanced Cellulose Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- cellulose nanocrystals, alginate, polycaprolactone, polyvinyl alcohol, nanofibers, electrospinning, mechanical properties, hydrophilicity, cell viability, cell attachment, cotton waste, hydrolysis, scaffolds
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