Mussel-inspired antimicrobial gelatin/chitosan tissue adhesive rapidly activated in situ by H2O2/ascorbic acid for infected wound closure
Abstract
The development of minimally invasive surgery has created a demand for ideal medical adhesives exhibiting biocompatibility, biodegradability, antimicrobial activity, and strong adhesion to tissues in wet environments. However, as clinically approved surgical tissue glues suffer from poor adhesion activation, limited adhesion strength, and toxicity, novel tissue glues are highly sought after. Herein, a mussel-inspired injectable hydrogel was prepared from catechol- and methacrylate-modified chitosan/gelatin and shown to exhibit biocompatibility, inherent antimicrobial activity, and good adhesion to wet tissues. Moreover, as this gel could be applied onto tissue surfaces and cured in situ within seconds of body contact by a biocompatible and multifunctional redox initiator (H 2 O 2 -ascorbic acid), it was concluded to be a promising surgical sealant and wound dressing (even for infected wounds) accelerating wound healing.
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The incorporation of DOPA or other catechol compounds endows hydrogels with enhanced adhesion and antimicrobial activity.
“The incorporation of DOPA or other catechol compounds endows hydrogels with enhanced adhesion and antimicrobial activity [36,105,106,107].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [107]
Cites
In situ cell manipulation through enzymatic hydrogel photopatterning
Mosiewicz, K. A., Kolb, L., van der Vlies, A. J., Martino, M. M., Lienemann, P. S., Hubbell, J. A., Ehrbar, M., & Lutolf, M. P. (2013) · Nature Materials · doi:10.1038/nmat3766 · Cited by 308 · see citing works
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Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications
Dou, W., Zeng, X., Zhu, S., Zhu, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169100 · Cited by 52 · see citing works
- Authors
- He, X. Y., Sun, A., Li, T., Qian, Y. J., Qian, H., Ling, Y. F., Zhang, L. H., Liu, Q. Y., Peng, T., & Qian, Z.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Qian, Zhiyong
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 247
- Pages
- 116692
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W3037152838
- Cited by
- 64
- References
- 1
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 11 · 2023: 13 · 2022: 16 · 2021: 9 · 2020: 1
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31525009, 31771096, 31930067)
- Sichuan University (ZYGD18002)
- National Key Research and Development Program of China (2017YFC1103502)
- West China Hospital, Sichuan University
- Topics
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- tissue adhesives, mussel-inspired adhesives, chitosan, gelatin, injectable hydrogel, in situ crosslinking, antimicrobial activity, wound dressings, surgical sealants, wound healing, wet tissue adhesion
- MeSH terms
- Sutureless Surgical Procedures, Animals, Anti-Bacterial Agents, Ascorbic Acid, Body Temperature, Catechols, Gelatin, Hydrogen Peroxide, Injections, Methacrylates, Pseudomonas aeruginosa, Staphylococcus aureus, Tissue Adhesives, Wound Healing, Wound Infection, Rats, Sprague-Dawley, Hydrogels, NIH 3T3 Cells, Chitosan, Bivalvia, Mice
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