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Cited by 369

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Self-healing hyaluronic acid hydrogels based on dynamic Schiff base linkages as biomaterials

Li, Shangzhi, Pei, Minjie, Wan, Tingting, Yang, Hongjun, Gu, Shaojin, Tao, Yongzhen, Liu, Xin, Zhou, Yingshan, Xu, Weilin, Xiao, Pu·2020·Carbohydrate Polymers
DOI 10.1016/j.carbpol.2020.116922
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Abstract

Natural hydrogels are widely investigated for biomedical applications because of their structures similar to extracellular matrix of native tissues, possessing excellent biocompatibility and biodegradability. However, they are often susceptible to mechanical disruption. In this study, self-healing hyaluronic acid (HA) hydrogels are fabricated through a facile dynamic covalent Schiff base reaction. Dialdehyde-modified HA (AHA) precursor was synthesized, and then the AHA/cystamine dihydrochloride (AHA/Cys) hydrogels were formed by blending AHA and Cys at acidic pH levels. By varying Cys to AHA ratio, the hydrogel morphology, swelling and kinetics of gelation could be controlled. Gelation occurred fast, which was predominantly attributed to Schiff base reaction between the dialdehyde groups on AHA and amimo groups on Cys. The hydrogel exhibited improved mechanical properties with increase in Cys content. Furthermore, due to dynamic imine bonds, this hydrogel demonstrated excellent self-healing ability based on the stress after mechanical disruption. Also, it was found to be pH-responsive and injectable. Taken together, this kind of hyaluronic acid hydrogel can provide promising future for various biomedical applications in drug delivery, bioprinting, smart robots and tissue regeneration.

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Metadata

Authors
Li, S., Pei, M., Wan, T., Yang, H., Gu, S., Tao, Y., Liu, X., Zhou, Y., Xu, W., & Xiao, P.
Venue
Carbohydrate Polymers
Publisher
Elsevier BV
Published
2020-12
Volume
250
Pages
116922
ISSN
0144-8617 (ISSN-L)
DOI
10.1016/j.carbpol.2020.116922
OpenAlex
W3049094321
Cited by
369
References
45
FWCI
9.72
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Self-healing hyaluronic acid hydrogels based on dynamic Schiff base linkages as biomaterials. https://app.cochat.ai/papers/10.1016/j.carbpol.2020.116922
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Li, S., Pei, M., Wan, T., Yang, H., Gu, S., Tao, Y., Liu, X., Zhou, Y., Xu, W., & Xiao, P. (2020). Self-healing hyaluronic acid hydrogels based on dynamic Schiff base linkages as biomaterials. Carbohydrate Polymers. https://doi.org/10.1016/j.carbpol.2020.116922

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.