The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Copper doped carbon dots modified bacterial cellulose with enhanced antibacterial and immune regulatory functions for accelerating wound healing
Abstract
The microenvironment of wound healing is susceptible to bacterial infection, chronic inflammation, oxidative stress, and inadequate angiogenesis, requiring the development of innovative wound dressings with antibacterial, anti-inflammatory, antioxidant, and angiogenic capabilities. This research crafted a new multifunctional bacterial cellulose composite membrane infused with copper-doped carbon dots (BC/Cu(II)-RCDs). Findings validated the successful loading of copper-doped carbon dots onto the BC membrane via hydrogen bonding interactions. Compared to the pure BC membrane, the BC/Cu(II)-RCDs composite membrane exhibited significantly enhanced hydrophilicity, tensile properties, and thermal stability. Diverse in vitro assays demonstrated excellent biocompatibility and antibacterial activity of BC/Cu(II)-RCDs composite membranes, alongside their ability to expedite the inflammatory phase and stimulate angiogenesis. In vivo trials corroborated the membrane's ability to foster epithelial regeneration, collagen deposition, and tissue regrowth in full-thickness skin wounds in rats while also curbing inflammation in infected full-thickness skin wounds. More importantly, the treatment of the BC/Cu(II)-RCDs composite membrane may result in the activation of VEGF and MAPK signaling proteins, which are key players in cell migration, angiogenesis, and skin tissue development. In essence, the developed BC/Cu(II)-RCDs composite membrane shows promise for treating infected wounds and serves as a viable alternative material for medicinal bandages.
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“Additionally, copper-containing biomaterials, mostly wound dressings, have shown significant potential in promoting the healing of infected wounds [68,87,91,92,93,94,95,96,97,98], including those infected with MRSA [99] and Escherichia coli biofilm [100].”
From The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice (2025) · cites this paper as [96]
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Cited by
Liu, X., Hu, H., Ma, J., & Wang, B. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123480 · Cited by 27
Borkow, G., & Melamed, E. (2025) · Biomedicines · doi:10.3390/biomedicines13030562 · Cited by 24
Mechanisms and design strategies of copper-incorporated dressings for wound management
Liu, X., Wang, M., Wang, R., Yang, J., & Wang, X. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.217310 · Cited by 23
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Metadata
- Authors
- Liu, Y., Zhao, Y., Guo, S., Qin, D., Yan, J., Cheng, H., Zhou, J., Ren, J., Sun, L., Peng, H., Wu, X., & Li, B.
- Affiliations
- Shanxi Medical University (CN)
- Capital Medical University (CN)
- Corresponding author
- Wu, Xiuping
- Li, Bing
- ORCID
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2024-12
- Volume
- 346
- Pages
- 122656
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W4401871887
- Cited by
- 54
- References
- 87
- Citations by year
- 2026: 34 · 2025: 20
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Update notices
- erratum (2025-01-01)
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Advanced Cellulose Research Studies
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- copper-doped carbon dots, bacterial cellulose, wound healing, antibacterial wound dressing, wound infection, angiogenesis, VEGF signaling, MAPK signaling, immune regulation, epithelial regeneration, collagen deposition, hydrogen bonding, composite membranes
- MeSH terms
- Animals, Anti-Bacterial Agents, Carbon, Cellulose, Copper, Humans, Male, Microbial Sensitivity Tests, Staphylococcus aureus, Wound Healing, Rats, Sprague-Dawley, Quantum Dots, Rats
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- CoChat. (2026). Citation check: Copper doped carbon dots modified bacterial cellulose with enhanced antibacterial and immune regulatory functions for accelerating wound healing. https://app.cochat.ai/papers/10.1016/j.carbpol.2024.122656
- The paper
- Liu, Y., Zhao, Y., Guo, S., Qin, D., Yan, J., Cheng, H., Zhou, J., Ren, J., Sun, L., Peng, H., Wu, X., & Li, B. (2024). Copper doped carbon dots modified bacterial cellulose with enhanced antibacterial and immune regulatory functions for accelerating wound healing. Carbohydrate Polymers. https://doi.org/10.1016/j.carbpol.2024.122656
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
