The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Reactive oxygen species (ROS) – a family of fate deciding molecules pivotal in constructive inflammation and wound healing
Open accessAbstract
Wound healing requires a fine balance between the positive and deleterious effects of reactive oxygen species (ROS); a group of extremely potent molecules, rate limiting in successful tissue regeneration. A balanced ROS response will debride and disinfect a tissue and stimulate healthy tissue turnover; suppressed ROS will result in infection and an elevation in ROS will destroy otherwise healthy stromal tissue. Understanding and anticipating the ROS niche within a tissue will greatly enhance the potential to exogenously augment and manipulate healing. Tissue engineering solutions to augment successful healing and remodelling of wounded or diseased tissue rely on a controlled balance between the constructive and destructive capacity of the leukocyte secretome, including ROS. This review comprehensively considers leukocyte derived ROS in tissue repair with particular interest in surgical intervention with inclusion of a biomaterial. The article considers ROS fundamental chemistry, formation, stimulation and clearance before applying this to discuss the implications of ROS in healing tissue with and without a biomaterial. We also systematically discuss ROS in leukocyte signalling and compare and contrast experimental means of measuring ROS.
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Cites
Neutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971
Fcγ receptors as regulators of immune responses
Nimmerjahn, F., & Ravetch, J. V. (2008) · Nature Reviews Immunology · doi:10.1038/nri2206 · Cited by 2,947
Zelko, I. N., Mariani, T. J., & Folz, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00905-x · Cited by 2,212
Nathan, C., & Shiloh, M. U. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.8841 · Cited by 1,469
Mitochondrial reactive oxygen species drive proinflammatory cytokine production
Naik, E., & Dixit, V. M. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110367 · Cited by 783
Host response to tissue engineered devices
Babensee, J. E., Anderson, J. M., McIntire, L. V., & Mikos, A. G. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00023-4 · Cited by 585
Molecular basis for Rac2 regulation of phagocyte NADPH oxidase
Diebold, B. A., & Bokoch, G. M. (2001) · Nature Immunology · doi:10.1038/85259 · Cited by 318
Ligand recognition by antigen-presenting cell C-type lectin receptors
McGreal, E. P., Miller, J. L., & Gordon, S. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.12.001 · Cited by 310
Pattern recognition receptors in the immune response against dying cells
Jeannin, P., Jaillon, S., & Delneste, Y. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.04.013 · Cited by 165
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Dunnill, C., Patton, T., Brennan, J., Barrett, J., Dryden, M., Cooke, J., Leaper, D., & Georgopoulos, N. T. (2017) · International Wound Journal · doi:10.1111/iwj.12557 · Cited by 1,380
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Sanchez, A. M., Viganò, P., Somigliana, E., Panina-Bordignon, P., Vercellini, P., & Candiani, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt053 · Cited by 357
Metadata
- Authors
- University of Liverpool - School of Clinical Sciences, U. C. F. T. E. G. F., Bryan, N., Ahswin, H., Smart, N., Bayon, Y., Wohlert, S., & Hunt, J.
- Venue
- European Cells and Materials
- Publisher
- Forum Multimedia Publishing LLC
- Published
- 2012-09-24
- Volume
- 24
- Pages
- 249-265
- ISSN
- 1473-2262 (ISSN-L)
- OpenAlex
- W272581626
- Cited by
- 318
- References
- 11
- FWCI
- 15.98
- Type
- journal article
- Language
- en
- Open access
- gold
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- University of Liverpool - School of Clinical Sciences, U. C. F. T. E. G. F., Bryan, N., Ahswin, H., Smart, N., Bayon, Y., Wohlert, S., & Hunt, J. (2012). Reactive oxygen species (ROS) – a family of fate deciding molecules pivotal in constructive inflammation and wound healing. European Cells and Materials. https://doi.org/10.22203/ecm.v024a18
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
