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Cited by 11Cardiomyopathy and Myosin StudiesCardiac Fibrosis and RemodelingCardiac electrophysiology and arrhythmias

Increased Myosin Heavy Chain-β With Atrial Expression of Ventricular Light Chain-2 in Canine Cardiomyopathy

Fuller, Geraldine A., Bicer, Sabahattin, Hamlin, Robert L., Yamaguchi, Mamoru, Reiser, Peter J.·2007·Journal of Cardiac Failure
DOI 10.1016/j.cardfail.2007.05.006
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Abstract

Background Dilated cardiomyopathy is a naturally occurring disease in humans and dogs. Human studies have shown increased levels of myosin heavy chain (MHC)-beta in failing ventricles and the left atria (LA) and of ventricular light chain (VLC)-2 in the right atria in dilated cardiomyopathy.Methods and results This study evaluates the levels of MHC-beta in all heart chambers in prolonged canine right ventricular pacing. In addition, we determined whether levels of VLC2 were altered in these hearts. Failing hearts demonstrated significantly increased levels of MHC-beta in the right atria, right atrial appendage, LA, left atrial appendage (LAA), and right ventricle compared with controls. Significant levels of VLC2 were detected in the right atria of paced hearts. Differences in MHC-beta expression were observed between the LA and the LAA of paced and control dogs. MHC-beta expression was significantly greater in the LA of paced and control dogs compared with their respective LAA.Conclusions The cardiac myosin isoform shifts in this study were similar to those observed in end-stage human heart failure and more severe than those reported in less prolonged pacing models, supporting the use of this model for further study of end-stage human heart failure. The observation of consistent differences between sampling sites, especially LA versus LAA, indicates the need for rigorous sampling consistency in future studies.

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Crossref · 10.1016/j.cardfail.2007.05.006

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  • Canine ventricular myocardium predominantly expresses slow beta-MHC (>80-100%), similar to humans (>90-95%).

    “The canine ventricular myocardium predominately expresses slow β-MHC (>80–100%) similar to humans (>90–95%) (Fuller, Bicer, Hamlin, Yamaguchi, & Reiser, 2007; Hamilton & Ianuzzo, 1991; Miyata, et al., 2000; Reiser, et al., 2001).”

    From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Fuller, et al., 2007

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Authors
Fuller, G. A., Bicer, S., Hamlin, R. L., Yamaguchi, M., & Reiser, P. J.
Affiliations
The Ohio State University (US)
ORCID
Venue
Journal of Cardiac Failure
Publisher
Elsevier BV
Published
2007-10
Volume
13
Issue
8
Pages
680-686
ISSN
1071-9164 (ISSN-L)
DOI
10.1016/j.cardfail.2007.05.006
OpenAlex
W2053524100
Cited by
11
References
35
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2019: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
0.23
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Cardiac Failure (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL45120)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
dilated cardiomyopathy, beta-myosin heavy chain, right ventricular pacing, left atrium, left atrial appendage, right atrium
MeSH terms
Animals, Dogs, Gene Expression Regulation, Cardiomyopathies, Atrial Function, Right, Myosin Light Chains, Myosin Heavy Chains, Nonmuscle Myosin Type IIB

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