The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice
Open accessAbstract
Nitric oxide (NO) is a gaseous molecule that plays many key roles in the cardiovascular system. Each of the enzymes that generate NO—neuronal, inducible and endothelial NO synthase—has been genetically disrupted in mice. This review discusses the cardiovascular phenotypes of each of the NO synthase (NOS) gene knockout mice, and the insights gained into the roles of NO in the cardiovascular system. Mice lacking the endothelial isoform are hypertensive, have endothelial dysfunction and show a more severe outcome in response to vascular injury, to stroke and cerebral ischaemia, and to diet-induced atherosclerosis. Mice lacking the neuronal isoform show a less severe outcome in response to stroke and cerebral ischaemia but have increased diet-induced atherosclerosis. Mice lacking the inducible isoform show reduced hypotension to septic shock. Together, NOS gene knockout mice have been useful tools that complement our other approaches to studying the multiple roles of NO in the cardiovascular system.
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Cited by
Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
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Vascular oxidative stress, nitric oxide and atherosclerosis
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Angiogenesis in the atherosclerotic plaque
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Metadata
- Authors
- Liu, V. W. T., & Huang, P. L.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01-01
- Volume
- 77
- Issue
- 1
- Pages
- 19-29
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- OpenAlex
- W2101301256
- Cited by
- 251
- References
- 12
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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