The DOI matches its Crossref record; 181 of the 183 references it cites were found in a registry or an index.
Chemical transmission in the sea anemone Nematostella vectensis: A genomic perspective
Abstract
The sequencing of the starlet sea anemone (Nematostella vectensis) genome provides opportunities to investigate the function and evolution of genes associated with chemical neurotransmission and hormonal signaling. This is of particular interest because sea anemones are anthozoans, the phylogenetically basal cnidarians least changed from the common ancestors of cnidarians and bilaterian animals, and because cnidarians are considered the most basal metazoans possessing a nervous system. This analysis of the genome has yielded 20 orthologues of enzymes and nicotinic receptors associated with cholinergic function, an even larger number of genes encoding enzymes, receptors and transporters for glutamatergic (28) and GABAergic (34) transmission, and two orthologues of purinergic receptors. Numerous genes encoding enzymes (14), receptors (60) and transporters (5) for aminergic transmission were identified, along with four adenosine-like receptors and one nitric oxide synthase. Diverse neuropeptide and hormone families are also represented, mostly with genes encoding prepropeptides and receptors related to varying closeness to RFamide (17) and tachykinin (14), but also galanin (8), gonadotropin-releasing hormones and vasopressin/oxytocin (5), melanocortins (11), insulin-like peptides (5), glycoprotein hormones (7), and uniquely cnidarian peptide families (44). Surprisingly, no muscarinic acetylcholine receptors were identified and a large number of melatonin-related, but not serotonin, orthologues were found. Phylogenetic tree construction and inspection of multiple sequence alignments reveal how evolutionarily and functionally distant chemical transmitter-related proteins are from those of higher metazoans.
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In the citing paper
“Also, one has to take into account the discrepancy of bioinformatic data with the empirical data (lack of serotonin orthologues in reference [37], with serotonin immunostaining in reference [26] in Nematostella).”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [37]
In the citing paper
“Bioinformatic analysis of the Nematostella genome has shown that a large number of genes associated with chemical neurotransmission are present [37].”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [37]
In the citing paper
“the assignment of cnidarian genes to a receptor class was exclusively based on homology to bilaterian receptors [52]”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [52]
In the citing paper
“the cnidarian nervous system extensively, and perhaps predominately, uses neuropeptides [52,55]”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [52]
In the citing paper
“In Nematostella the diversity of neuropeptides is matched by over 80 putative GPCRs for neuropeptides [52].”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [52]
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Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
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2 of the 183 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Pani, 1993, A quantitative survey of biogenic amines, their precursors and metabolites in the cnidarian Renilla koellikeri, Biog. Amines, 10, 161
- Yamamoto, 2001, vol. 18, 88
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The many faces of insulin-like peptide signalling in the brain
Fernandez, A. M., & Torres-Alemán, I. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3209 · Cited by 872
Drosophila neuropeptides in regulation of physiology and behavior
Nässel, D. R., & Winther, Å. M. E. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.010 · Cited by 498
Global view of the evolution and diversity of metazoan neuropeptide signaling
Jékely, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221833110 · Cited by 451
From nerve net to nerve ring, nerve cord and brain — evolution of the nervous system
Arendt, D., Tosches, M. A., & Marlow, H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.15 · Cited by 279
Glutamate-gated Chloride Channels
Wolstenholme, A. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.406280 · Cited by 285
Metadata
- Authors
- Anctil, M.
- Affiliations
- Université de Montréal (CA)
- Corresponding author
- Anctil, Michel
- Venue
- Comparative Biochemistry and Physiology Part D Genomics and Proteomics
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 4
- Issue
- 4
- Pages
- 268-289
- ISSN
- 1744-117X (ISSN-L)
- OpenAlex
- W2143838640
- Cited by
- 139
- References
- 183
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 11 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 27 · 2019: 11 · 2018: 11 · 2017: 3 · 2016: 7 · 2015: 13 · 2014: 12 · 2013: 4 · 2012: 7
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Comparative Biochemistry and Physiology Part D Genomics and Proteomics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Nematostella vectensis, chemical neurotransmission, cnidarian nervous system, Anthozoa, cholinergic neurotransmission, nicotinic acetylcholine receptors, glutamatergic neurotransmission, GABAergic neurotransmission, purinergic receptors, neuropeptides, hormones, RFamide, tachykinins, galanin, gonadotropin-releasing hormone, melanocortin peptides, insulin-like peptides, glycoprotein hormones, melatonin, serotonin, genome annotation
- MeSH terms
- Animals, Hormones, Nervous System, Neuropeptides, Sea Anemones, Genome, Neurotransmitter Agents
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