The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes
Abstract
Flavonoids and isoflavonoids are potent inhibitors of glucose efflux in human erythrocytes. Net changes of sugars inside the cells were measured by right angle light scattering. The inhibitory potency of hydroxylated flavonoids depends on the pH of the medium. The apparent affinity is maximal at low pH where the molecule is in the undissociated form. The following K(i)-values at pH 6.5 in microM have been obtained: phloretin 0.37+/-0.03, myricetin 0.76+/-0.42, quercetin 0.93+/-0.28, kaempferol 1.33+/-0.17, isoliquiritigenin 1.96, genistein 3.92+/-0.62, naringenin 8.88+/-1.88, 7-hydroxyflavone 17.58+/-3.15 and daidzein 18.62+/-2.85. Flavonoids carrying hydroxyl groups are weak acids and are deprotonated at high pH-values. From spectral changes pK-values between 6.80 (naringenin) and 7.73 (myricetin) have been calculated. No such pK-value could be obtained from quercetin which was rather unstable at alkaline pH. Flavone itself without a hydroxyl group does not demonstrate any absorbance changes at different pH-values and no significant change in inhibition of glucose transport with pH (K(i)-value around 35 microM). In this respect it is similar to the antiestrogens diethylstilbestrol, tamoxifen and cyclofenil with K(i)-values for glucose efflux inhibition of 2.61+/-0.30, 6.75+/-2.03 and 3.97+/-0.54 microM. Except for phloretin, the flavonoids investigated have planar structures. The inhibitory activity in glucose efflux of planar flavonoids increases exponentially with the numb…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203 · see citing works
Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., & Greene, G. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81717-1 · Cited by 2,726 · see citing works
Flavonoids, a class of natural products of high pharmacological potency
Havsteen, B. (1983) · Biochemical Pharmacology · doi:10.1016/0006-2952(83)90262-9 · Cited by 1,616 · see citing works
Sequence and Structure of a Human Glucose Transporter
Mueckler, M. M., Caruso, C., Baldwin, S. A., Panico, M., Blench, I., Morris, H. R., Allard, W. J., Lienhard, G. E., & Lodish, H. F. (1985) · Science · doi:10.1126/science.3839598 · Cited by 1,529 · see citing works
Flavonoids: Old and new aspects of a class of natural therapeutic drugs
Carlo, G. D., Mascolo, N., Izzo, A. A., & Capasso, F. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00120-4 · Cited by 1,307 · see citing works
Facilitative glucose transporters
Mueckler, M. M. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18550.x · Cited by 1,092 · see citing works
Pike, A. C. W., Brzozowski, A. M., Hubbard, R. E., Bonn, T., Thorsell, A., Engström, O., Ljunggren, J., Gustafsson, J., & Carlquist, M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4608 · Cited by 987 · see citing works
Wallis, T. E. (1910) · Botanical Gazette · doi:10.1086/330384 · Cited by 536 · see citing works
Commonly occurring plant flavonoids have estrogenic activity.
Miksicek, R. J. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13162-3 · Cited by 368 · see citing works
LeFevre, P. G. (1961) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07001-2 · Cited by 310 · see citing works
Molecular structure in relation to oestrogenic activity. Compounds without a phenanthrene nucleus
Dodds, E. C., & Lawson, W. E. (1938) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1938.0023 · Cited by 241 · see citing works
LeFevre, P. G., & Marshall, J. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69717-0 · Cited by 172 · see citing works
Plant pigments as natural food colours
Timberlake, C. F., & Henry, B. (1986) · Endeavour · doi:10.1016/0160-9327(86)90048-7 · Cited by 152 · see citing works
THE REABSORPTION OF GLUCOSE FROM THE RENAL TUBULE IN AMPHIBIA AND THE ACTION OF PHLORHIZIN UPON IT
Walker, A. M., & Hudson, C. L. (1936) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1936.118.1.130 · Cited by 92 · see citing works
Molecular Structural Factors in Competitive Inhibition of Sugar Transport
LeFevre, P. G. (1959) · Science · doi:10.1126/science.130.3367.104 · Cited by 62 · see citing works
Wilbrandt, W. (1950) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00245645 · Cited by 46 · see citing works
The kinetics of carrier transport inhibition
Rosenberg, T., & Wilbrandt, W. (1962) · Experimental Cell Research · doi:10.1016/0014-4827(62)90047-2 · Cited by 24 · see citing works
Fuhrmann, G. F., Dernedde, S., & Frenking, G. (1992) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(92)90300-b · Cited by 20 · see citing works
Self-citationLenné (1894) · Cited by 19 · see citing works
Phloretin, A Weak Estrogen and Estrogen Antagonist
Lerner, L. J., TURKHEIMER, A. R., & Borman, A. (1963) · Experimental Biology and Medicine · doi:10.3181/00379727-114-28601 · Cited by 14 · see citing works
[15] Transport studies in red blood cells by measuring light scattering
Fuhrmann, G. F. (1989) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(89)73017-2 · Cited by 12 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Bi, W., Tian, M., & Row, K. H. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.02.041 · Cited by 455 · see citing works
Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery
Patching, S. (2017) · Molecular Neurobiology · doi:10.1007/s12035-015-9672-6 · Cited by 315 · see citing works
Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY‐876
Siebeneicher, H., Cleve, A., Rehwinkel, H., Neuhaus, R., Heisler, I., Müller, T., Bauser, M., & Buchmann, B. (2016) · ChemMedChem · doi:10.1002/cmdc.201600276 · Cited by 294 · see citing works
Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer
Akins, N. S., Nielson, T. C., & Le, H. V. (2018) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026618666180523111351 · Cited by 254 · see citing works
A Review on Pharmacological and Analytical Aspects of Naringenin
Patel, K., Singh, G. K., & Patel, D. K. (2014) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-014-1960-x · Cited by 248 · see citing works
Role of polyphenols in combating Type 2 Diabetes and insulin resistance
Shahwan, M. J., Alhumaydhi, F. A., Ashraf, G. M., Hasan, P. M. Z., & Shamsi, A. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.03.004 · Cited by 229 · see citing works
GLUT1 as a therapeutic target in hepatocellular carcinoma
Amann, T., & Hellerbrand, C. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903307509 · Cited by 205 · see citing works
Salas-Burgos, A., Iserovich, P., Zuñiga, F. A., Vera, J. C., & Fischbarg, J. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.047886 · Cited by 198 · see citing works
Xintaropoulou, C., Ward, C., Wise, A., Marston, H. M., Turnbull, A., & Langdon, S. P. (2015) · Oncotarget · doi:10.18632/oncotarget.4499 · Cited by 161 · see citing works
Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rat soleus muscle
Jorge, A. P. F., Horst, H., Trichês, E. D. S., Pizzolatti, M. G., & Silva, F. R. M. B. (2004) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2004.07.001 · Cited by 160 · see citing works
Ma, Y., Wang, W., Idowu, M. O., Oh, U., Wang, X.-Y., Temkin, S. M., & Fang, X. (2018) · Cancers · doi:10.3390/cancers11010033 · Cited by 145 · see citing works
Azevedo, C., Correia‐Branco, A., Araújo, J. R., Guimarães, J. T., Keating, E., & Martel, F. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1002625 · Cited by 125 · see citing works
Targeting of cancer energy metabolism
Rodríguez‐Enríquez, S., Marín‐Hernández, Á., Gallardo‐Pérez, J. C., Carreño‐Fuentes, L., & Moreno‐Sánchez, R. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700470 · Cited by 118 · see citing works
Effects of Polyphenols on Insulin Resistance
Williamson, G., & Sheedy, K. (2020) · Nutrients · doi:10.3390/nu12103135 · Cited by 118 · see citing works
Bond dissociation free energy as a general parameter for flavonoid radical scavenging activity
Stepanić, V., Gall‐Tros̆elj, K., Lučić, B., Marković, Z., & Amić, D. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.03.072 · Cited by 107 · see citing works
Docking Studies Show That D-Glucose and Quercetin Slide through the Transporter GLUT1
Cunningham, P., Afzal‐Ahmed, I., & Naftalin, R. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509422200 · Cited by 107 · see citing works
Contrasting Effects of Puerarin and Daidzin on Glucose Homeostasis in Mice
Meezan, E., MEEZAN, E., Jones, K., Moore, R., Barnes, S., & PRASAIN, J. K. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf058105e · Cited by 93 · see citing works
Labak, C. M., Wang, P. Y., Arora, R., Guda, M. R., Asuthkar, S., Tsung, A. J., & Velpula, K. K. (2016) · Europe PMC (PubMed Central) · Cited by 90 · see citing works
Patel, K., Kumar, V., Rahman, M., Verma, A., & Patel, D. K. (2017) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1016/j.bjbas.2017.05.009 · Cited by 86 · see citing works
The Progress and Development of GLUT1 Inhibitors Targeting Cancer Energy Metabolism
Meng, Y., Xu, X. J., Luan, H., Li, L., Dai, W., Li, Z., & Bian, J. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0052 · Cited by 82 · see citing works
Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1
Hamilton, K. E., Rekman, J. F., Gunnink, L. K., Busscher, B. M., Scott, J. L., Tidball, A. M., Stehouwer, N. R., Johnecheck, G. N., Looyenga, B. D., & Louters, L. L. (2018) · Biochimie · doi:10.1016/j.biochi.2018.05.012 · Cited by 84 · see citing works
Inhibitory Effects of Polyphenols on P-Glycoprotein-Mediated Transport
Kitagawa, S. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.1 · Cited by 82 · see citing works
Kitagawa, S., Sakamoto, H., & Tano, H. (2004) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.52.999 · Cited by 82 · see citing works
Cazarolli, L. H., Zanatta, L. C. B., Jorge, A. P. F., Trichês, E. D. S., Horst, H., Woehl, V. M., Pizzolatti, M. G., Szpoganicz, B., & Silva, F. R. M. B. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.07.010 · Cited by 82 · see citing works
Uhlenhut, K., & Högger, P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.04.013 · Cited by 77 · see citing works
Anticancer agents interacting with membrane glucose transporters
Granchi, C., Fortunato, S., & Minutolo, F. (2016) · MedChemComm · doi:10.1039/c6md00287k · Cited by 71 · see citing works
Kerimi, A., & Williamson, G. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7086 · Cited by 66 · see citing works
New Approach for Treatment of Primary Liver Tumors: The Role of Quercetin
Brito, A. F., Ribeiro, M., Abrantes, A. M., Mamede, A. C., Laranjo, M., Casalta‐Lopes, J., Gonçalves, A. C., Sarmento‐Ribeiro, A. B., Tralhão, J. G., & Botelho, M. F. (2016) · Nutrition and Cancer · doi:10.1080/01635581.2016.1145245 · Cited by 62 · see citing works
Sánchez, J., Preis, K. A., & Seidel, G. E. (2006) · Reproduction Fertility and Development · doi:10.1071/rd05063 · Cited by 57 · see citing works
Sztandera, K., Działak, P., Marcinkowska, M., Stańczyk, M., Gorzkiewicz, M., Janaszewska, A., & Klajnert‐Maculewicz, B. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2673-9 · Cited by 56 · see citing works
Glycolysis Inhibition as a Strategy for Hepatocellular Carcinoma Treatment?
Alves, Â., Mamede, A. C., Alves, M. G., Oliveira, P. F., Rocha, S. M., Botelho, M. F., & Maia, C. J. (2018) · Current Cancer Drug Targets · doi:10.2174/1568009618666180430144441 · Cited by 50 · see citing works
Lee, S. Y., Park, J.-H., Ko, S.-H., Shim, J.-S., Kim, D., & Cho, H. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b06582 · Cited by 50 · see citing works
Identification of novel GLUT inhibitors
Siebeneicher, H., Bauser, M., Buchmann, B., Heisler, I., Müller, T. H., Neuhaus, R., Rehwinkel, H., Telser, J., & Zorn, L. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.02.050 · Cited by 49 · see citing works
Phloretin inhibits Zika virus infection by interfering with cellular glucose utilisation.
Lin, S.-C., Chen, M.-C., Liu, S.-F., Callahan, V., Bracci, N. R., Lehman, C., Dahal, B., de la Fuente, C. L., Lin, C.-C., Wang, T. T., et al. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.03.017 · Cited by 38 · see citing works
Conformational Studies of Glucose Transporter 1 (GLUT1) as an Anticancer Drug Target
Almahmoud, S. A., Wang, X., Vennerstrom, J. L., & Zhong, H. A. (2019) · Molecules · doi:10.3390/molecules24112159 · Cited by 46 · see citing works
Nasri, R., Bidel, L., Rugani, N., Perrier, V., Carrière, F., Dubreucq, É., & Jay‐Allemand, C. (2019) · Molecules · doi:10.3390/molecules24162888 · Cited by 40 · see citing works
Kerimi, A., Jailani, F., & Williamson, G. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400850 · Cited by 38 · see citing works
Zhang, D., Wang, Y., Dong, L., Huang, Y., Yuan, J., Ben, W., Yang, Y., Ning, N., Lu, M., & Guan, Y. (2013) · Cancer Science · doi:10.1111/cas.12293 · Cited by 38 · see citing works
Udrea, A.-M., Pîrcălăbioru, G. G., Boboc, A. A., Mareş, C., Dinache, A., Mernea, M., & Avram, S. (2021) · Biomolecules · doi:10.3390/biom11111692 · Cited by 38 · see citing works
Kurlbaum, M., Mülek, M., & Högger, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063197 · Cited by 33 · see citing works
Flavonóides : potencial terapêutico no estresse oxidativo.
Dornas, W. C., de Oliveira, T. T., das Dôres, R. G. R., dos Santos, A. F., & Nagem, T. J. (2007) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 33 · see citing works
Quercetin is a substrate for the transmembrane oxidoreductase Dcytb
Vlachodimitropoulou, E., Naftalin, R. J., & Sharp, P. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.02.021 · Cited by 34 · see citing works
Brain Transport Profiles of Ginsenoside Rb1 by Glucose Transporter 1: In Vitro and in Vivo
Wang, Y.-Z., Xu, Q., Wu, W., Liu, Y., Jiang, Y., Cai, Q., Lv, Q., & Li, X. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00398 · Cited by 30 · see citing works
Effect of flavonoids on basal and insulin‐stimulated 2‐deoxyglucose uptake in adipocytes
Claussnitzer, M., Skurk, T., Hauner, H., Daniel, H., & Rist, M. J. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000372 · Cited by 28 · see citing works
Plant‐derived glucose transport inhibitors with potential antitumor activity
Shriwas, P., Chen, X., Kinghorn, A. D., & Ren, Y. (2019) · Phytotherapy Research · doi:10.1002/ptr.6587 · Cited by 26 · see citing works
Patching, S. G. (2015) · Journal of Diagnostic Imaging in Therapy · doi:10.17229/jdit.2015-0301-014 · Cited by 23 · see citing works
Natural Antioxidants Improve Red Blood Cell “Survival” in Non-Leukoreduced Blood Samples
Kucherenko, Y. V., & Bernhardt, I. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000374012 · Cited by 22 · see citing works
Szkudelska, K., Nogowski, L., Nowicka, E., & Szkudelski, T. (2006) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2006.00647.x · Cited by 19 · see citing works
Zhang, S., Wang, X., Zhang, R., Cui, Y., Zhang, H., Song, W., Hou, X., Fu, S., Gao, Q., & Liu, S. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.338593 · Cited by 18 · see citing works
Are tyrosine kinases involved in mediating contraction-stimulated muscle glucose transport?
Wright, D. C., Geiger, P. C., Han, D., & Holloszy, J. O. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00280.2005 · Cited by 18 · see citing works
Chamarthy, S., & Ramaiah, M. J. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01207-5 · Cited by 17 · see citing works
Ligand-based design of GLUT inhibitors as potential antitumor agents
Almahmoud, S. A., Jin, W., Geng, L., Wang, J., Wang, X., Vennerstrom, J. L., & Zhong, H. A. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115395 · Cited by 17 · see citing works
Taneja, I., Kanumuri, R. S., & Wahajuddin, M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1045968 · Cited by 16 · see citing works
Niklas, J., Nonnenmacher, Y., Rose, T., Sandig, V., & Heinzle, E. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3811-4 · Cited by 14 · see citing works
Mebendazole targets essential proteins in glucose metabolism leading gastric cancer cells to death
da Silva, E. L., Mesquita, F. P., Aragão, D. R., Portilho, A. J. D. S., Marinho, A. D., de Oliveira, L. L. B., Lima, L. B., de Moraes, M. E. A., Souza, P. F. N., & Montenegro, R. C. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116630 · Cited by 13 · see citing works
Smith, T., Sharma, R. I., Wang, W., Welch, A. E., Schweiger, L. F., & Collie-Duguid, E. S. R. (2007) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2007.07.007 · Cited by 12 · see citing works
Salah, A., El-Laban, N. M., Alam, S. M., Islam, M. S., Hussein, M. A., & Roshdy, T. M. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.123967 · Cited by 11 · see citing works
Tamoxifen: an emerging preventive
Schwartz, J. (2004) · Frontiers in bioscience · doi:10.2741/1440 · Cited by 11 · see citing works
Liu, S., Song, W., Cui, Y., Sun, Z., Huang, Z., & Gao, Q. (2021) · Chemical Communications · doi:10.1039/d1cc00343g · Cited by 10 · see citing works
Bie, F., Zhang, G., Yan, X., Ma, X., Zhan, S., Qiu, Y., Cao, J., Ma, Y., & Ma, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.896904 · Cited by 10 · see citing works
Chen, X., Tan, J., Zhang, L., Liu, Y., Cheng, Y., Zhang, Q., & Ding, H. (2018) · RSC Advances · doi:10.1039/c8ra04459g · Cited by 10 · see citing works
Identification of novel inhibitors of GLUT1 by virtual screening and cell-based assays
Chen, X., Zhao, Y., Lyu, S., Gao, G., Gao, Y., Qi, Y., & Du, J. (2021) · Investigational New Drugs · doi:10.1007/s10637-021-01109-2 · Cited by 10 · see citing works
Channels for water efflux and influx involved in volume regulation of murine spermatozoa
Callies, C., Cooper, T. G., & Yeung, C. (2008) · Reproduction · doi:10.1530/rep-08-0149 · Cited by 10 · see citing works
Genistein inhibits glucose and sulphate transport in isolated rat liver lysosomes
Chou, H.-F., Chuang, K.-H., Tsai, Y.-S., & Chen, Y. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991693 · Cited by 10 · see citing works
Belmouhoub, M., Bribi, N., & Iguer‐Ouada, M. (2016) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-016-0252-8 · Cited by 9 · see citing works
GLUT1: a promising drug target for cancer treatment
Chen, X., Zhao, Y., Gao, Y., Qi, Y., & Du, J. (2021) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000001029 · Cited by 8 · see citing works
Tchamgoue, J., Tchokokam, Y. R. W., Ngouonpe, A. W., Ngandjui, Y. A. T., Tiani, G. L. M., Msagati, T. A. M., Ngadjui, B. T., Green, I. R., & Kouam, S. F. (2023) · Fitoterapia · doi:10.1016/j.fitote.2023.105754 · Cited by 7 · see citing works
Geng, H., Chen, L., Lv, S., Li, M., Huang, X., Li, M., Liu, C., & Liu, C. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00469 · Cited by 7 · see citing works
Small-molecule inhibitors of glucose transporters
Kawatani, M., & Osada, H. (2024) · Vitamins and hormones · doi:10.1016/bs.vh.2024.06.001 · Cited by 7 · see citing works
jera, O. N. (2013) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp2013.3798 · Cited by 4 · see citing works
Novel Therapeutic Targets for Hepatocellular Carcinoma Treatment
Chen, Y., & Han, C. (2012) · InTech eBooks · doi:10.5772/28894 · Cited by 2 · see citing works
Gonzalez, T., & Govers, R. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.12.040 · Cited by 1 · see citing works
Koltai, T., Reshkin, S. J., & Harguindey, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819059-3.00002-2 · Cited by 1 · see citing works
THE EFFECT OF DIETARY POLYPHENOLS ON GLUCOSE UPTAKE BY BREAST CANCER CELLS (MCF-7)
Filipa, C., Azevedo, M., & Apresentada, D. D. M. (2013)
Saraswaty, V., Wulandari, R., Ardiansyah, A., Nida, V., Mufti, N., Suryana, R., Septina, W., & Setiyanto, H. (2025) · Journal of Umm Al-Qura University for Applied Sciences · doi:10.1007/s43994-025-00302-w
Feng, J., Yan, Y., Liang, J., Zhao, Y., Zhang, J., Xu, J., Ma, S., Zhang, S., & Xie, S. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12679-w
BindingDB Entry 50047188: Identification of novel GLUT inhibitors.
BindingDB (2017) · UC San Diego · doi:10.7270/q2639rm3
BindingDB (2025) · UC San Diego · doi:10.7270/q22f7t5j
- Authors
- Martin, H.-J., Kornmann, F., & Fuhrmann, G. F.
- Affiliations
- Philipps University of Marburg (DE)
- Corresponding author
- Fuhrmann, Günter Fred
- ORCID
- Kornmann, Frank
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 146
- Issue
- 3
- Pages
- 225-235
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W2057656781
- Cited by
- 80
- References
- 21
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 1 · 2013: 6 · 2012: 2
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Keywords
- flavonoids, isoflavonoids, antiestrogens, GLUT1 glucose transporter, human erythrocytes, phloretin, myricetin, quercetin, kaempferol, isoliquiritigenin, genistein, naringenin, daidzein, flavones, diethylstilbestrol, tamoxifen, cyclofenil, pK values, pH dependence, hydroxyl number, planar structures
- MeSH terms
- Erythrocytes, Flavonoids, Humans, Hydrogen-Ion Concentration, Kinetics, Monosaccharide Transport Proteins, Estrogen Receptor Modulators, Glucose Transporter Type 1, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review