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A New Spectral Shift-Based Method to Characterize Molecular Interactions

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GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells

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Development of Glucose Transporter (GLUT) Inhibitors

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Cellular effects and clinical implications of SLC2A3 copy number variation

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Recent advancements in therapeutic targeting of the Warburg effect in refractory ovarian cancer: A promise towards disease remission

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Metabolic Reprogramming in Stromal and Immune Cells in Rheumatoid Arthritis and Osteoarthritis: Therapeutic Possibilities

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Hypoxia induces the translocation of glucose transporter 1 to the plasma membrane in vascular endothelial cells

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Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes

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H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death

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Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor

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Chemical biology probes of mammalian GLUT structure and function

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Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays

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Exploiting metabolic cell death for cancer therapy

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Hypoxia and its therapeutic possibilities in paediatric cancers

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Cellular binding and uptake of fluorescent glucose analogs 2-NBDG and 6-NBDG occurs independent of membrane glucose transporters

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Conformational Studies of Glucose Transporter 1 (GLUT1) as an Anticancer Drug Target

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Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses

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Reciprocal change in Glucose metabolism of Cancer and Immune Cells mediated by different Glucose Transporters predicts Immunotherapy response

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Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension

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Inhibition of Endoplasmic Reticulum Stress Cooperates with SLC7A11 to Promote Disulfidptosis and Suppress Tumor Growth upon Glucose Limitation

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AHR Regulates Metabolic Reprogramming to Promote SIRT1-Dependent Keratinocyte Differentiation

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GLUT1 Biological Function and Inhibition: Research Advances

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An appraisal of the current status of inhibition of glucose transporters as an emerging antineoplastic approach: Promising potential of new pan-GLUT inhibitors

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Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles

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Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma

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Ultra-stable MOF@MOF nanoplatform for photodynamic therapy sensitized by relieved hypoxia due to mitochondrial respiration inhibition

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Role of Glucose Metabolic Reprogramming in Breast Cancer Progression and Drug Resistance

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Identification and characterization of a novel SNAT2 (SLC38A2) inhibitor reveals synergy with glucose transport inhibition in cancer cells

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Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in Vitro

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Permuted 2,4-thiazolidinedione (TZD) analogs as GLUT inhibitors and their in-vitro evaluation in leukemic cells

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Endothelial GLUTs and vascular biology

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Targeting RAS mutants in malignancies: successes, failures, and reasons for hope

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Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis

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In what area of biology has a “new” type of cell death been discovered?

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Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia

Lewis, A. C., Gruber, E., Franich, R. L., Armstrong, J. M., Kelly, M. J., Opazo, C., Low, Y. C., Flippe, L., Wijanarko, K. J., Rowe, C. L., et al. (2025) · Cell · doi:10.1016/j.cell.2025.10.028 · Cited by 35 · see citing works

AMPKα2/HNF4A/BORIS/GLUT4 pathway promotes hepatocellular carcinoma cell invasion and metastasis in low glucose microenviroment

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Identification of a novel GLUT1 inhibitor with in vitro and in vivo anti-tumor activity

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Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss

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Bad neighbours: hypoxia and genomic instability in prostate cancer

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A Novel Microcrystalline BAY-876 Formulation Achieves Long-Acting Antitumor Activity Against Aerobic Glycolysis and Proliferation of Hepatocellular Carcinoma

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Tumor Microenvironment-Derived Metabolites: A Guide to Find New Metabolic Therapeutic Targets and Biomarkers

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Characterization of the effect of the GLUT-1 inhibitor BAY-876 on T cells and macrophages

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Pharmacological inhibition of GLUT1 as a new immunotherapeutic approach after myocardial infarction

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Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism

Zügner, E., Yang, H., Kotzbeck, P., Boulgaropoulos, B., Sourij, H., Hagvall, S., Elmore, C. S., ESTERLINE, R. L., Moosmang, S., Oscarsson, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147966 · Cited by 33 · see citing works

Discovery and Optimization of Glucose Uptake Inhibitors

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Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation

Burgart, Y. V., Agafonova, N. A., Shchegolkov, E. V., Красных, О. П., Kushch, S. O., Evstigneeva, N. P., Герасимова, Н. А., Владимировна, М. В., Триандафилова, Г. А., Solodnikov, S. Y., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112768 · Cited by 29 · see citing works

Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A

Wortmann, L., Bräuer, N., Holton, S. J., Irlbacher, H., Weiske, J., Lechner, C., Meier, R., Karén, J., Sioberg, C., Pütter, V., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01245 · Cited by 28 · see citing works

MiR-378a inhibits glucose metabolism by suppressing GLUT1 in prostate cancer

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Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity

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Molecular Tools for Facilitative Carbohydrate Transporters (Gluts)

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Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells

Guo, L., Zhang, W., Xie, Y., Chen, X., Olmstead, E. E., Lian, M., Zhang, B., Zaytseva, Y. Y., Evers, B. M., Spielmann, H. P., et al. (2022) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0925 · Cited by 28 · see citing works

GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes

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Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering

Heitmeier, M. R., Hresko, R. C., Edwards, R. L., Prinsen, M. J., Ilagan, M. X. G., John, A. R. O., & Hruz, P. W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216457 · Cited by 27 · see citing works

Abstract 4333: Identification and optimization of the first highly selective GLUT-1 inhibitors

Bauser, M., Buchmann, B., Siebeneicher, H., Cleve, A., Rehwinkel, H., Neuhaus, R., Heisler, I., Mueller, T., & Kopitz, C. (2016) · Cancer Research · doi:10.1158/1538-7445.am2016-4333

Cover Picture: Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY‐876 (ChemMedChem 20/2016)

Siebeneicher, H., Cleve, A., Rehwinkel, H., Neuhaus, R., Heisler, I., Müller, T. H., Bauser, M., & Buchmann, B. (2016) · ChemMedChem · doi:10.1002/cmdc.201600503 · Cited by 1 · see citing works

Abstract 4746: Pharmacological characterization of BAY-876, a novel highly selective inhibitor of glucose transporter (GLUT)-1 in vitro and in vivo

Kopitz, C., Toschi, L., Algire, C., Héroult, M., Frisk, A.-L., Meyer, K., Schmitz, A., Lagkadinou, E., Petrul, H. M., Heisler, I., et al. (2016) · Cancer Research · doi:10.1158/1538-7445.am2016-4746 · Cited by 9 · see citing works

Isoform-Selective Targeting of Facilitative Glucose Transporters with Small Molecule Inhibitors

Heitmeier, M. R., Hresko, R. C., Shanmugam, M., & Hruz, P. W. (2018) · Diabetes · doi:10.2337/db18-1779-p

Identification of novel GLUT inhibitors

Siebeneicher, H., Bauser, M., Buchmann, B., Heisler, I., Müller, T. H., Neuhaus, R., Rehwinkel, H., Telser, J., & Zorn, L. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.02.050 · Cited by 49 · see citing works