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Cited by 38Aluminum toxicity and tolerance in plants and animalsHeavy Metal Exposure and ToxicityDrug-Induced Hepatotoxicity and Protection

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Protective and prophylactic effects of chlorogenic acid on aluminum-induced acute hepatotoxicity and hematotoxicity in mice

Cheng, Dai, Zhang, Xinyu, Xu, Lihan, Li, Xiang, Hou, Lihua, Wang, Chunling·2017·Chemico-Biological Interactions
DOI 10.1016/j.cbi.2017.06.013
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Abstract

The possible health impact of the exposures to Al from environment would be inevitable for humans. Using chelating agents and natural antioxidants against Al-induced biotoxicity become a natural and modern way to prevent the adverse effects of Al in people. This study was undertaken to determine the effectiveness of chlorogenic acid (CGA, 5-O-caffeoylquinic acid) in preventing aluminum chloride (AlCl 3) induced hepatotoxicity and hematotoxicity in mice. Control, Al-treated (a single injection of 25 mg Al 3+/kg, i.p.), Al + CGA (2 h after, a single dose of 100 mg/kg, i.p.), CGA + Al (administered to mice daily for 5 days at 30 mg/kg before Al-treatment) and group of CGA per se (administered to mice daily for 5 days at 30 mg/kg) were used. The levels of Al in liver and blood, the activities of transaminases in serum and osmotic fragility were increased by comparison with the control, while the activities of superoxide dismutase and catalase decreased significantly in the Al-treated group. However, treating mice with CGA at either dosing regimens, post- or pre- Al administration alleviate Al oxidative damaging effects, stabilize cell membrane, prevent hepatocyte apoptosis. CGA supplementation may be favorable to avoid Al-induced hematotoxicity and hepatotoxicity for humans.

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  • Chlorogenic acid is effective as a chelating agent and antioxidant in protection against the toxicity of Al.

    “Chlorogenic acid was effective as a chelating agent and antioxidant in protection against the toxicity of Al (Wang et al., 2018; Cheng et al., 2017, 2019).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Cheng et al., 2017

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Research works printed but not linked: 60

  1. Gill, 2006, Neurofilament phosphorylation and disruption: a possible mechanism of chronic aluminium toxicity in Wistar rats, Toxicology, 219, 1, 10.1016/j.tox.2005.09.015 · DOI
  2. Greger, 1992, Assessment of exposure to parenteral and oral aluminum with and without citrate using a desferrioxamine test in rats, Toxicology, 76, 119, 10.1016/0300-483X(92)90159-C · DOI
  3. Yokel, 2002, Aluminum chelation principles and recent advances, Coord. Chem. Rev., 228, 97, 10.1016/S0010-8545(02)00078-4 · DOI
  4. Gonzales, 2009, The interactions between the chronic exposure to Aluminum and liver regeneration on bile flow and organic anion transport in rats, Biol. Trace Elem. Res., 127, 164, 10.1007/s12011-008-8234-4 · DOI
  5. Walton, 2013, Aluminum involvement in the progression of Alzheimer's disease, J. Alzheimers Dis., 35, 7, 10.3233/JAD-121909 · DOI
  6. Tripathi, 2008, Aluminum-mediated metabolic changes in rat serum and urine: a proton nuclear magnetic resonance study, J. Biochem. Mol. Toxicol., 22, 119, 10.1002/jbt.20219 · DOI
  7. Alessandra, 2008, Effects of aluminium sulphate in the mouse liver: similarities to the aging process, Exp. Gerontol., 43, 330, 10.1016/j.exger.2008.01.009 · DOI
  8. Yousef, 2004, Aluminium induced changes in hemato-biochemical parameters, lipid peroxidation and enzymes activities of male rabbits: protective role of ascorbic acid, Toxicology, 199, 47, 10.1016/j.tox.2004.02.014 · DOI
  9. Gonzales, 2007, Involvement of oxidative stress in the impairment in biliary secretory function induced by intraperitoneal administration of aluminium to rats, Biol. Trace Elem. Res., 116, 329, 10.1007/BF02698017 · DOI
  10. Beardmore, 2007, A systems biology approach to the blood-aluminium problem: the application and testing of a computational model, J. Inorg. Biochem., 101, 1187, 10.1016/j.jinorgbio.2007.06.015 · DOI
  11. Wills, 1983, Aluminium poisoning:dialysis encephalopathy, osteomalacia, and anaemia, Lancet, 2, 29, 10.1016/S0140-6736(83)90014-4 · DOI
  12. Priest, 2004, The biological behaviour and bioavailability of aluminium in man, J. Environ. Monit., 6, 375, 10.1039/B314329P · DOI
  13. Cheng, 2014, Protective effect of apple (Ralls) polyphenol extract against aluminum-induced cognitive impairment and oxidative damage in rat, Neurotoxicology, 45, 111, 10.1016/j.neuro.2014.10.006 · DOI
  14. Cheng, 2012, The protective effects of polyphenols from jujube peel (Ziziphus Jujube Mill) on isoproterenol-induced myocardial ischemia and aluminum-induced oxidative damage in rats, Food Chem. Toxicol., 50, 1302, 10.1016/j.fct.2012.01.026 · DOI
  15. Feng, 2005, Inhibition of activator protein1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid, J. Biol. Chem., 280, 27888, 10.1074/jbc.M503347200 · DOI
  16. Yun, 2012, Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties, J. Nutr. Biochem., 23, 1249, 10.1016/j.jnutbio.2011.06.018 · DOI
  17. Zhou, 2016, Chlorogenic acid ameliorates endotoxin-induced liver injury by promoting mitochondrial oxidative phosphorylation, Biochem. Biophys. Res. Commun., 22, 1083, 10.1016/j.bbrc.2015.12.094 · DOI
  18. Ohnishi, 1994, Inhibitory effects of chlorogenic acids on linoleic acid peroxidation and haemolysis, Phytochemistr, 36, 579, 10.1016/S0031-9422(00)89778-2 · DOI
  19. Aggarwal, 2013, Propitious role of chlorogenic acid and Donepezil on arsenic neurovascular toxicity induced endothelial dysfunction and vascular dementia, Indian J. Pharmacol., 45, 99
  20. Hao, 2015, Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model, Exp. Ther. Med., 9, 1887, 10.3892/etm.2015.2367 · DOI
  21. Xu, 2014, Tetrachlorobenzoquinone induces acute liver injury, up-regulates HO-1 and NQO1 expression in mice model: the protective role of chlorogenic acid, Environ. Toxicol. Pharmacol., 37, 1212, 10.1016/j.etap.2014.04.022 · DOI
  22. El-Sayed, 2011, Prophylactic and therapeutic effects of taurine against aluminum-induced acute hepatotoxicity in mice, J. Hazard Mater., 30, 880, 10.1016/j.jhazmat.2011.05.100 · DOI
  23. Bagdas, 2015, In vivo systemic chlorogenic acid therapy under diabetic conditions: wound healing effects and cytotoxicity/genotoxicity profile, Food Chem. Toxicol., 81, 54, 10.1016/j.fct.2015.04.001 · DOI
  24. Sinha, 2007, A 43kD protein from the herb, Cajanus indicus L., protects against fluoride induced oxidative stress in mice erythrocytes, Pathophysiology, 14, 47, 10.1016/j.pathophys.2007.01.001 · DOI
  25. Ansari, 2015, Sodium nitrite-induced oxidative stress causes membrane damage, protein oxidation, lipid peroxidation and alters major metabolic pathways in human erythrocytes, Toxicol. Vitro, 29, 1878, 10.1016/j.tiv.2015.07.022 · DOI
  26. Hitoshi, 2005, Structure-dependent and receptor-independent increase in osmotic fragility of rat erythrocytes by short-chain fatty acids, Biochim. Biophys. Acta, 1713, 113, 10.1016/j.bbamem.2005.05.007 · DOI
  27. Lowery, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI
  28. Saberzadeh, 2016, Alpha synuclein protein is involved in Aluminum-induced cell death and oxidative stress in PC12 cells, Brain Res., 1635, 153, 10.1016/j.brainres.2016.01.037 · DOI
  29. Rivest, 2009, Powerful beneficial effects of macrophage colonystimulating factor on b-amyloid deposition and cognitive impairment in Alzheimer's disease, Brain, 132, 1078
  30. Puchades, 1989, Rapid digestion procedure for the determination of lead in vegetable tissues by electrothermal atomisation atomic absorption spectrometry, Analyst, 114, 1397, 10.1039/AN9891401397 · DOI
  31. Neal, 2010, Molecular neurobiology of lead (Pb(2+)):effects on synaptic function, Mol. Neurobiol., 42, 151, 10.1007/s12035-010-8146-0 · DOI
  32. Waalkes, 1994, Cadmium and prostate cancer, J. Toxicol.Environ. Health, 43, 251, 10.1080/15287399409531920 · DOI
  33. Lisiewicz, 1993, Immunotoxic and hematotoxic effects of occupational exposures, Folia Med. Cracov., 34, 29
  34. Crisponi, 2012, Chelating agents for human diseases related to aluminum overload, Coord. Chem. Rev., 256, 89, 10.1016/j.ccr.2011.06.013 · DOI · Paper page
  35. González, 2009, The interactions between the chronic exposure to Aluminum and liver regeneration on bile flow and organic anion transport in rats, Biol. Trace Elem. Res., 127, 164, 10.1007/s12011-008-8234-4 · DOI
  36. Mailloux, 2011, Hepatic response to aluminum toxicity: dyslipidemia and liver diseases, Exp. Cell Res., 317, 2231, 10.1016/j.yexcr.2011.07.009 · DOI · Paper page
  37. Exley, 2001, Aluminum and Alzheimer's disease, J. Alzheimers Dis., 3, 551, 10.3233/JAD-2001-3605 · DOI
  38. Greger, 1997, Aluminum exposure and metabolism, Crit. Rev. Clin. Lab. Sci., 34, 439, 10.3109/10408369709006422 · DOI
  39. Türkez, 2010, Propolis prevents aluminium-induced genetic and hepatic damages in rat liver, Food Chem. Toxicol., 48, 2741, 10.1016/j.fct.2010.06.049 · DOI · Paper page
  40. Nikolova, 1994, The functional and morphological changes in the liver and kidneys of white rats treated with aluminum, Eksp. Med. Morfol., 32, 52
  41. González, 2007, Involvement of oxidative stress in the impairment in biliary secretory function induced by chronic administration of aluminum to rats, Biol. Trace Elem. Res., 116, 329, 10.1007/BF02698017 · DOI
  42. Pratico, 2002, Aluminium modulates brain amyloidosis through oxidative stress in APP transgenic mice, Faseb J., 16, 1138, 10.1096/fj.02-0012fje · DOI · Paper page
  43. Exley, 2004, The pro-oxidant activity of aluminum, Free Radic. Biol. Med., 36, 380, 10.1016/j.freeradbiomed.2003.11.017 · DOI
  44. Rimon, 2002, Diagnosis of iron deficiency anemia in the elderly by transferrin receptor-ferritin index, Arch. Intern. Med., 162, 445, 10.1001/archinte.162.4.445 · DOI
  45. Raina, 2010, Impaired mitochondrial energy metabolism and kinetic properties of cytochrome oxidase following acute aluminium phosphide exposure in rat liver, Food Chem. Toxicol., 48, 53, 10.1016/j.fct.2009.09.014 · DOI
  46. Newairy, 2009, Propolis alleviates aluminium-induced lipid peroxidation and biochemical parameters in male rats, Food Chem. Toxicol., 47, 1093, 10.1016/j.fct.2009.01.032 · DOI
  47. Yousef, 2004, Aluminium-induced changes in hemato-biochemical parameters, lipid peroxidation and enzyme activities of male rabbits: protective role of ascorbic acid, Toxicology, 199, 47, 10.1016/j.tox.2004.02.014 · DOI
  48. Bogdanovic, 2008, Histopathological changes in rat liver after a single high dose of aluminium, Arh. Hig. Rada Toksikol., 59, 97, 10.2478/10004-1254-59-2008-1859 · DOI
  49. Kumar, 2009, Aluminium-induced oxidative DNA damage recognition and cell-cycle disruption in different regions of rat brain, Toxicology, 264, 137, 10.1016/j.tox.2009.05.011 · DOI
  50. Bhalla, 2010, Potential of lithium to reduce aluminium induced cytotoxic effects in rat brain, BioMetals, 23, 197, 10.1007/s10534-009-9278-4 · DOI
  51. Sharma, 2016, Quercetin attenuates neuronal death against aluminum-induced neurodegeneration in the rat hippocampus, Neuroscience, 324, 163, 10.1016/j.neuroscience.2016.02.055 · DOI · Paper page
  52. Cinkilic, 2013, Radioprotection by two phenolic compounds: chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro, Food Chem. Toxicol., 53, 359, 10.1016/j.fct.2012.12.008 · DOI
  53. Aremu, 2005, Accumulation of aluminum by primary cultured astrocytes from aluminum amino acid complex and its apoptotic effect, Brain Res., 1031, 284, 10.1016/j.brainres.2004.06.090 · DOI
  54. Johnson, 2005, Aluminum-maltolate induces apoptosis and necrosis in neuro-2a cells: potential role for p53 signaling, Toxicol. Sci., 83, 329, 10.1093/toxsci/kfi028 · DOI
  55. Magisetty, 2009, Studies on genomic DNA stability in aluminium-maltolate treated aged New Zealand rabbit: relevance to the Alzheimers animal model, J. Clin. Med. Res., 1, 212
  56. Rui, 2010, Aluminum chloride induced oxidative damage on cells derived from hippocampus and cortex of ICR mice, Brain Res., 1324, 96, 10.1016/j.brainres.2010.02.024 · DOI
  57. Ghribi, 2001, Coinvolvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits, Brain Res., 903, 66, 10.1016/S0006-8993(01)02406-4 · DOI
  58. Fisher, 1994, Apoptosis in cancer therapy: crossing the threshold, Cell, 78, 539, 10.1016/0092-8674(94)90518-5 · DOI
  59. Bazzoni, 2005, In vivo effect of aluminium upon the physical properties of the erythrocyte membrane, J. Inorg. Biochem., 99, 822, 10.1016/j.jinorgbio.2004.12.012 · DOI · Paper page
  60. Bonarska-Kujawa, 2015, Molecular mechanism of action of chlorogenic acid on erythrocyte and lipid membranes, Mol. Membr. Biol., 32, 46, 10.3109/09687688.2015.1031833 · DOI

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Metadata

Authors
Cheng, D., Zhang, X., Xu, L., Li, X., Hou, L., & Wang, C.
Affiliations
Tianjin University of Science and Technology (CN)
Corresponding author
Cheng, Dai
ORCID
Venue
Chemico-Biological Interactions
Publisher
Elsevier BV
Published
2017-08
Volume
273
Pages
125-132
ISSN
0009-2797 (ISSN-L)
DOI
10.1016/j.cbi.2017.06.013
OpenAlex
W2625383339
Cited by
38
References
0
Citations by year
2026: 3 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 9 · 2018: 3 · 2017: 1
FWCI
4.58
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Chemico-Biological Interactions (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Tianjin Natural Science Foundation (16JCQNJC15000)
  • TUST Innovation Fund for Young Scholars (2015LG25)
  • National Key R&D Program (2016YFNC010104-01)
  • Open Foundation of Beijing Advanced Innovation Center for Food Nutrition and Human Health (20161029)
  • National Undergraduate Training Programs for Innovation and Entrepreneurship (201610057052)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
chlorogenic acid, aluminum chloride, aluminum toxicity, hepatotoxicity, hematologic toxicity, oxidative stress, antioxidant enzymes, superoxide dismutase, catalase, hepatocyte apoptosis, osmotic fragility, transaminases, hepatoprotection, prophylaxis, natural antioxidants
MeSH terms
Aluminum Chloride, Animals, Chlorides, Chlorogenic Acid, Dose-Response Relationship, Drug, Injections, Intraperitoneal, Liver, Male, Mice, Inbred Strains, Structure-Activity Relationship, Apoptosis, Aluminum Compounds, Chemoprevention, Protective Agents, Hepatocytes, Mice

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