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In vivo effect of aluminium upon the physical properties of the erythrocyte membrane
Abstract
Aluminium (Al (III)) is a metal with no biological function. Its organic accumulation can lead to toxic effects. To elucidate the in vivo effect of Al (III) upon the rheological properties of the erythrocyte membrane, male adult Wistar rats have been submitted to periodical injections of Al(OH)3 during three months. Significant decreases in haematocrit (34+/-0.37% versus 36+/-0.20%, p<0.0001) and blood haemoglobin concentration (10.7+/-0.15 g/dl versus 12.3+/-0.49 g/dl, p<0.005) have been found. Haemolysis curves shifted towards the left, indicating that erythrocytes became more resistant to hypotonic haemolysis. Significant increments in rigidity index (29.6+/-1.59 versus 9.2+/-0.40, p<0.0001), relative viscosity at native haematocrit (3.6+/-0.03 versus 3.5+/-0.03, p<0.04), and relative viscosity at standard haematocrit (4.5+/-0.06 versus 3.9+/-0.05, p<0.0001) have been observed. The decrease in the erythrocyte aggregate size (1.6+/-0.01 versus 1.7+/-0.01, p<0.002) and the aggregation rate (0.5+/-0.02 versus 0.6+/-0.03, p<0.002) indicated a significantly dropped aggregability process. In conclusion, Al (III) disorganised the erythrocyte membrane by altering its mechanical properties, suggesting a reduction of the middle life of circulating erythrocytes, which could play a major role in the anaemia of these animals.
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Erythrocyte osmotic fragility decreased or increased depending on the Al speciation and type of erythrocyte injury.
“Erythrocyte osmotic fragility decreased (Bazzoni et al., 2005) or increased (Zatta et al., 1989; Hernández et al., 2008; Al-Qayim et al., 2014; Oztürk and Ozdemir, 2015, Zhang et al., 2016; Cheng et al., 2018) depending on the Al speciation and type of erythrocyte injury.”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Bazzoni et al., 2005
Eryptotic (apoptotic) injury reduces erythrocyte aggregate size because of the shrinking effect, thereby increasing osmotic resistance.
“Eryptotic (apoptotic) injury reduces the erythrocyte aggregate size (Bazzoni et al., 2005) because of the shrinking effect, thereby increasing osmotic resistance (Igbokwe, 2016).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Bazzoni et al., 2005
Additional causes of anemia appear to be multi-factorial and include defective hemoglobin production due to inhibition of enzymes of heme synthesis, altered erythrocyte membrane structure and fragility, shortening of red blood cell life span due to eryptotic and oncotic injuries, and inadequate iron utilization.
“The additional causes of anemia appear to be multi-factorial and include defective hemoglobin production due to inhibition of the enzymes of heme synthesis, altered erythrocyte membrane structure and fragility, shortening of red blood cell life span due to eryptotic and oncotic injuries, and inadequate iron utilization (Zatta et al., 1989; Perez et al., 2001; Bazzoni et al., 2005; Vittori et al.,”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Bazzoni et al., 2005
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Vittori, D., Nesse, A., Pérez, G., & Garbossa, G. (1999) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(99)00122-1 · Cited by 66
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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“The additional causes of anemia appear to be multi-factorial and include defective hemoglobin production due to inhibition of the enzymes of heme synthesis, altered erythrocyte membrane structure and fragility, shortening of red blood cell life span due to eryptotic and oncotic injuries, and inadequate iron utilizatio…”
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Metadata
- Authors
- Bazzoni, G. B., Bollini, A. N., Hernández, G. N., Contini, M. D. C., Chiarotto, M. M., & Rasia, M. L.
- Affiliations
- National University of Rosario (AR)
- Universidad Nacional del Litoral (AR)
- Corresponding author
- Bazzoni, Graciela B.
- Venue
- Journal of Inorganic Biochemistry
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 99
- Issue
- 3
- Pages
- 822-827
- ISSN
- 0162-0134 (ISSN-L)
- OpenAlex
- W2021060820
- Cited by
- 29
- References
- 1
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Inorganic Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
- Keywords
- aluminum toxicity, aluminum hydroxide, erythrocyte membrane, membrane rheology, erythrocyte rigidity, erythrocyte aggregation, hemolysis, hematocrit, hemoglobin, anemia, erythrocyte lifespan, membrane mechanics
- MeSH terms
- Aluminum, Anemia, Hemolytic, Autoimmune, Animals, Blood Viscosity, Cations, Erythrocyte Aggregation, Erythrocyte Deformability, Erythrocyte Membrane, Hematocrit, Hemoglobins, Hemolysis, Kinetics, Rats
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