The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Non-genetic cell-to-cell variability and the consequences for pharmacology
Open accessAbstract
Summary Recent advances in single-cell assays have focused attention on the fact that even members of a genetically identical group of cells or organisms in identical environments can exhibit variability in drug sensitivity, cellular response, and phenotype. Underlying much of this variability is stochasticity in gene expression, which can produce unique proteomes even in genetically identical cells. Here we discuss the consequences of non-genetic cell-to-cell variability in the cellular response to drugs and its potential impact for treatment of human disease.
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Citations
Cites
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Stochastic mRNA Synthesis in Mammalian Cells
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Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
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Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
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“However, the proteome also influences epigenetic regulation of gene expression [14,15] and it has been suggested that the expression levels of certain proteins influence the probability that mutations will be fixed [16].”
Multidimensional Drug Profiling By Automated Microscopy
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Cited by
Chen, J.-Y., Lin, J.-R., Tsai, F.-C., & Meyer, T. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.09.009 · Cited by 144
Bai, X., Fisher, D. E., & Flaherty, K. T. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0204-6 · Cited by 107
Transient and stable vector transfection: Pitfalls, off-target effects, artifacts
Stepanenko, A. A., & Heng, H. H. (2017) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2017.05.002 · Cited by 109
Quantitating drug-target engagement in single cells in vitro and in vivo
Dubach, J. M., Kim, E., Yang, K., Cuccarese, M., Giedt, R. J., Meimetis, L. G., Vinegoni, C., & Weissleder, R. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2248 · Cited by 87
Han, L., Zi, X., Garmire, L. X., Wu, Y., Weissman, S. M., Pan, X., & Fan, R. (2014) · Scientific Reports · doi:10.1038/srep06485 · Cited by 83
Metadata
- Authors
- Niepel, M., Spencer, S. L., & Sorger, P. K.
- Venue
- Current Opinion in Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 13
- Issue
- 5-6
- Pages
- 556-561
- ISSN
- 1367-5931 (ISSN-L)
- OpenAlex
- W2146447332
- Cited by
- 215
- References
- 8
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Niepel, M., Spencer, S. L., & Sorger, P. K. (2009). Non-genetic cell-to-cell variability and the consequences for pharmacology. Current Opinion in Chemical Biology. https://doi.org/10.1016/j.cbpa.2009.09.015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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