Multidimensional Drug Profiling By Automated Microscopy

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An Information-Intensive Approach to the Molecular Pharmacology of Cancer

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Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes

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Camptothecin: current perspectives

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Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex.

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Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

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Target discovery

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DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling

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High content screening applied to large-scale cell biology

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Automatic Identification of Subcellular Phenotypes on Human Cell ArraysPreprint

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Histone deacetylase as a new target for cancer chemotherapy

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Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro

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Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data.

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Natural products as probes of cell biology: 20 years of didemnin research

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Robust Numerical Features for Description and Classification of Subcellular Location Patterns in Fluorescence Microscope Images

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The Ribotoxic Stress Response as a Potential Mechanism for MAP Kinase Activation in Xenobiotic Toxicity

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SCMD: Saccharomyces cerevisiae Morphological Database

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Biological mechanism profiling using an annotated compound library

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Advances in molecular labeling, high throughput imaging and machine intelligence portend powerful functional cellular biochemistry tools

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Chemical Genomic Profiling of Biological Networks Using Graph Theory and Combinations of Small Molecule Perturbations

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CellProfiler: image analysis software for identifying and quantifying cell phenotypes

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Cellular Heterogeneity: Do Differences Make a Difference?

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Multi-target therapeutics: when the whole is greater than the sum of the parts

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Target identification using drug affinity responsive target stability (DARTS)

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Target identification and mechanism of action in chemical biology and drug discovery

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Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

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Opportunities and challenges in phenotypic drug discovery: an industry perspective

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Data-analysis strategies for image-based cell profiling

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Molecular Networking as a Dereplication Strategy

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Dynamic Proteomics of Individual Cancer Cells in Response to a Drug

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Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity

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Biological imaging software tools

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Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators

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Screening out irrelevant cell-based models of disease

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Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

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Massively multiplex chemical transcriptomics at single-cell resolution

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Systematic exploration of essential yeast gene function with temperature-sensitive mutants

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High-throughput fluorescence microscopy for systems biology

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High-Throughput Screening: today’s biochemical and cell-based approaches

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Image-based profiling for drug discovery: due for a machine-learning upgrade?

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High content screening: seeing is believing

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Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

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Data-driven modelling of signal-transduction networks

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Cellular imaging in drug discovery

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Functional classification of drugs by properties of their pairwise interactions

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Image-based multivariate profiling of drug responses from single cells

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Quantitative Morphological Signatures Define Local Signaling Networks Regulating Cell Morphology

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Machine learning in cell biology – teaching computers to recognize phenotypes

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Label-free cell cycle analysis for high-throughput imaging flow cytometry

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Multiplex Cytological Profiling Assay to Measure Diverse Cellular States

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Chemical combination effects predict connectivity in biological systems

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High-speed fluorescence image–enabled cell sorting

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Automated Subcellular Location Determination and High-Throughput Microscopy

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Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

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Lensless high-resolution on-chip optofluidic microscopes for Caenorhabditis elegans and cell imaging

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High-Content Screening for Quantitative Cell Biology

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Kinetic Cell-Based Morphological Screening: Prediction of Mechanism of Compound Action and Off-Target Effects

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Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements

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Quantitative Phase Imaging

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An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules

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Cell microarrays and RNA interference chip away at gene function

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Cell-Based Assays for High-Throughput Screening

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Increasing the Content of High-Content Screening: An Overview

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Non-genetic cell-to-cell variability and the consequences for pharmacology

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Label-free chemical imaging flow cytometry by high-speed multicolor stimulated Raman scattering

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Comparison of Methods for Image-Based Profiling of Cellular Morphological Responses to Small-Molecule Treatment

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Identification of Gene Positioning Factors Using High-Throughput Imaging Mapping

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The beautiful cell: high-content screening in drug discovery

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Combination chemical genetics

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High-Content Phenotypic Profiling of Drug Response Signatures across Distinct Cancer Cells

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Applications in image-based profiling of perturbations

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Machine learning and image-based profiling in drug discovery

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Automated microscopy for high-content RNAi screening

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Defining principles of combination drug mechanisms of action

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A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays

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Machine learning and computer vision approaches for phenotypic profiling

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Characterizing heterogeneous cellular responses to perturbations

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Quantitative Time-Lapse Fluorescence Microscopy in Single Cells

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A multichannel nanosensor for instantaneous readout of cancer drug mechanisms

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NeurphologyJ: An automatic neuronal morphology quantification method and its application in pharmacological discovery

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Clustering phenotype populations by genome-wide RNAi and multiparametric imaging

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Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations

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Toward a Confocal Subcellular Atlas of the Human Proteome

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