Cited by 217Molecular Sensors and Ion DetectionAdvanced Fluorescence Microscopy TechniquesTrace Elements in Health

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Imaging mobile zinc in biology

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Tomat, Elisa, Lippard, Stephen J·2010·Current Opinion in Chemical Biology

DOI 10.1016/j.cbpa.2009.12.010PMC PMC2847655

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Abstract

Trafficking and regulation of mobile zinc pools influence cellular functions and pathological conditions in multiple organs, including brain, pancreas, and prostate. The quest for a dynamic description of zinc distribution and mobilization in live cells fuels the development of increasingly sophisticated probes. Detection systems that respond to zinc binding with changes of their fluorescence emission properties have provided sensitive tools for mobile zinc imaging, and fluorescence microscopy experiments have afforded depictions of zinc distribution within live cells and tissues. Both small-molecule and protein-based fluorescent probes can address complex imaging challenges, such as analyte quantification, site-specific sensor localization, and real-time detection.

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Authors: Tomat, E., & Lippard, S. J.
Affiliations: Massachusetts Institute of Technology (US)
Corresponding author: Lippard, Stephen J
ORCID: Tomat, Elisa
Lippard, Stephen J
Venue: Current Opinion in Chemical Biology
Publisher: Elsevier BV
Published: 2010-04
Volume: 14
Issue: 2
Pages: 225-230
ISSN: 1367-5931 (ISSN-L)
DOI: 10.1016/j.cbpa.2009.12.010
PMC: PMC2847655
OpenAlex: W1567645807
Cited by: 217
References: 0
Citations by year: 2026: 3 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 10 · 2018: 12 · 2017: 11 · 2016: 14 · 2015: 14 · 2014: 31 · 2013: 32 · 2012: 34
FWCI: 2.67
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Chemical Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
Funders: National Institutes of Health (5r01gm065519-16)
National Institute of General Medical Sciences (R01‐GM065519, GM065519)
Topics: Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: zinc imaging, zinc regulation, fluorescent probes, live-cell imaging, chemical probes, real-time detection
MeSH terms: Animals, Fluorescent Dyes, Humans, Microscopy, Fluorescence, Spectrometry, Fluorescence, Zinc, Biosensing Techniques

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