Unique insights to intrinsically disordered proteins provided by ion mobility mass spectrometry

Intrinsically unstructured proteins and their functions

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Classification of Intrinsically Disordered Regions and Proteins

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Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

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Analytical Properties of the Nanoelectrospray Ion Source

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Coupling of folding and binding for unstructured proteins

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The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

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Understanding protein non-folding

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Ion mobility–mass spectrometry

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Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

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Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

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Electrospray and Taylor-Cone theory, Dole's beam of macromolecules at last?

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Modelling Myc inhibition as a cancer therapy

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‘Molten‐globule state’: a compact form of globular proteins with mobile side‐chains

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Applications of a travelling wave‐based radio‐frequency‐only stacked ring ion guide

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Comparing and Combining Predictors of Mostly Disordered Proteins

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Electrospray ionization of large multiply charged species proceeds via Dole’s charged residue mechanism

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A Protein-Chameleon: Conformational Plasticity of α-Synuclein, a Disordered Protein Involved in Neurodegenerative Disorders

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A new method of separation of multi-atomic ions by mobility at atmospheric pressure using a high-frequency amplitude-asymmetric strong electric field

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Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability

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Chaperone Activity of ERD10 and ERD14, Two Disordered Stress-Related Plant Proteins

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Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation

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How useful is ion mobility mass spectrometry for structural biology? The relationship between protein crystal structures and their collision cross sections in the gas phase

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Interconversion between two unrelated protein folds in the lymphotactin native state

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Unstructural biology coming of age

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Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry

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Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding

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Native ion mobility-mass spectrometry and related methods in structural biology

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Gas-phase ions of solute species from charged droplets of solutions

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Elongated oligomers in β 2 -microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry

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Therapeutic Targeting of Myc

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Chemical cross‐linking and native mass spectrometry: A fruitful combination for structural biology

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Phenylalanine Oligomers and Fibrils: The Mechanism of Assembly and the Importance of Tetramers and Counterions

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Human Apolipoprotein C-II Forms Twisted Amyloid Ribbons and Closed Loops

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FuzDB: database of fuzzy complexes, a tool to develop stochastic structure-function relationships for protein complexes and higher-order assemblies

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Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

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Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper

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A Mass-Spectrometry-Based Framework To Define the Extent of Disorder in Proteins

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Dynamics of Intact Immunoglobulin G Explored by Drift‐Tube Ion‐Mobility Mass Spectrometry and Molecular Modeling

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The C-Terminal Half of the Anti-Sigma Factor FlgM Contains a Dynamic Equilibrium Solution Structure Favoring Helical Conformations

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Thermal Unfolding of Unsolvated Cytochrome c: Experiment and Molecular Dynamics Simulations

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Intrinsically Disordered p53 and Its Complexes Populate Compact Conformations in the Gas Phase

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Folding of Protein Ions in the Gas Phase after Cation-to-Anion Proton-Transfer Reactions

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Mass spectrometry methods for intrinsically disordered proteins

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Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding

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On the supertertiary structure of proteins

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Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein

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Relating gas phase to solution conformations: Lessons from disordered proteins

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Spermine Binding to Parkinson’s Protein α-Synuclein and Its Disease-Related A30P and A53T Mutants

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Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry

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Conformational dynamics of α-synuclein: insights from mass spectrometry

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Ensemble Methods Enable a New Definition for the Solution to Gas-Phase Transfer of Intrinsically Disordered Proteins

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The Solution Assembly of Biological Molecules Using Ion Mobility Methods: From Amino Acids to Amyloid β-Protein

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Are Charge-State Distributions a Reliable Tool Describing Molecular Ensembles of Intrinsically Disordered Proteins by Native MS?

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Molecular Basis for Structural Heterogeneity of an Intrinsically Disordered Protein Bound to a Partner by Combined ESI-IM-MS and Modeling

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Proton Dynamics in Protein Mass Spectrometry

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Probing the Conformational Diversity of Cancer‐Associated Mutations in p53 with Ion‐Mobility Mass Spectrometry

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Intrinsic disorder in proteins: a challenge for (un)structural biology met by ion mobility–mass spectrometry

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Raman optical activity of human α‐synuclein in intrinsically disordered, micelle‐bound α‐helical, molten globule and oligomeric β‐sheet state

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Insights into the Conformations of Three Structurally Diverse Proteins: Cytochrome c , p53, and MDM2, Provided by Variable-Temperature Ion Mobility Mass Spectrometry

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Dissecting the Dynamic Conformations of the Metamorphic Protein Lymphotactin

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Characterizing Early Aggregates Formed by an Amyloidogenic Peptide by Mass Spectrometry

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The use of ion mobility mass spectrometry to probe modulation of the structure of p53 and of MDM2 by small molecule inhibitors

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Electron transfer with no dissociation ion mobility–mass spectrometry (ETnoD IM-MS). The effect of charge reduction on protein conformation

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Molecular Insights into the Thermal Stability of mAbs with Variable‐Temperature Ion‐Mobility Mass Spectrometry

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Charge Mediated Compaction and Rearrangement of Gas-Phase Proteins: A Case Study Considering Two Proteins at Opposing Ends of the Structure-Disorder Continuum

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Early stages of insulin fibrillogenesis examined with ion mobility mass spectrometry and molecular modelling

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Nursing some sense out of Myc

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Utilising ion mobility-mass spectrometry to interrogate macromolecules: Factor H complement control protein modules 10–15 and 19–20 and the DNA-binding core domain of tumour suppressor p53

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Imaging the Morphology and Structure of Apolipoprotein Amyloid Fibrils

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The molecular basis for cellular function of intrinsically disordered protein regions

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Cross-Linking Mass Spectrometry for Investigating Protein Conformations and Protein–Protein Interactions─A Method for All Seasons

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Ion Mobility Mass Spectrometry (IM-MS) for Structural Biology: Insights Gained by Measuring Mass, Charge, and Collision Cross Section

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Higher-order structural characterisation of native proteins and complexes by top-down mass spectrometry

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SLIM Ultrahigh Resolution Ion Mobility Spectrometry Separations of Isotopologues and Isotopomers Reveal Mobility Shifts due to Mass Distribution Changes

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Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins

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Features of molecular recognition of intrinsically disordered proteins via coupled folding and binding

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Mass Spectrometry Methods for Measuring Protein Stability

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An arsenal of methods for the experimental characterization of intrinsically disordered proteins – How to choose and combine them?

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Experimental Confirmation of a Topological Isomer of the Ubiquitous Au25(SR)18 Cluster in the Gas Phase

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Fuzzy Drug Targets: Disordered Proteins in the Drug-Discovery Realm

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Initial Protein Unfolding Events in Ubiquitin, Cytochrome c and Myoglobin Are Revealed with the Use of 213 nm UVPD Coupled to IM-MS

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Weighing-up protein dynamics: the combination of native mass spectrometry and molecular dynamics simulations

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Structural Proteomics Methods to Interrogate the Conformations and Dynamics of Intrinsically Disordered Proteins

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Charge Movement and Structural Changes in the Gas-Phase Unfolding of Multimeric Protein Complexes Captured by Native Top-Down Mass Spectrometry

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Computational Strategies and Challenges for Using Native Ion Mobility Mass Spectrometry in Biophysics and Structural Biology

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Structural mass spectrometry goes viral

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Taking Charge: Metal Ions Accelerate Amyloid Aggregation in Sequence Variants of α-Synuclein

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Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview

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Dissecting the structural heterogeneity of proteins by native mass spectrometry

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Navigating the Expansive Landscapes of Soft Materials: A User Guide for High-Throughput Workflows

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Ion Mobility-Mass Spectrometry in Metabolomic, Lipidomic, and Proteomic Analyses

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Some opinions on MD-based vibrational spectroscopy of gas phase molecules and their assembly: An overview of what has been achieved and where to go

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Conformational assignment of gas phase peptides and their H-bonded complexes using far-IR/THz: IR-UV ion dip experiment, DFT-MD spectroscopy, and graph theory for mode assignment

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The role of solvation on the conformational landscape of α-synuclein

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Advances in mass spectrometry to unravel the structure and function of protein condensates

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Top/Middle-Down Characterization of α-Synuclein Glycoforms

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In a flash of light: X-ray free electron lasers meet native mass spectrometry

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Protein Unfolding in Freeze Frames: Intermediate States are Revealed by Variable-Temperature Ion Mobility–Mass Spectrometry

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The Use of Mass Spectrometry to Examine IDPs: Unique Insights and Caveats

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Ion Mobility Mass Spectrometry Measures the Conformational Landscape of p27 and its Domains and how this is Modulated upon Interaction with Cdk2/cyclin A

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Extended disorder at the cell surface: The conformational landscape of the ectodomains of syndecans

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Time-Resolved Ion Mobility Mass Spectrometry to Solve Conformational Changes in a Cryptochrome

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Native mass spectrometry for the investigation of protein structural (dis)order

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Depicting Conformational Ensembles of α-Synuclein by Single Molecule Force Spectroscopy and Native Mass Spectroscopy

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Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation

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Exploring Conformational Landscapes Using Trap and Release Tandem Ion Mobility Spectrometry

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Characterization of native protein structure with ion mobility mass spectrometry, multiplexed fragmentation strategies and multivariant analysis

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Mobility capillary electrophoresis–native mass spectrometry reveals the dynamic conformational equilibrium of calmodulin and its complexes

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Evaluating the Effects of Metal Adduction and Charge Isomerism on Ion-Mobility Measurements using m-Xylene Macrocycles as Models

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Conformational signatures induced by ubiquitin modification in the amyloid-forming tau repeat domain

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Gas‐phase conformations of intrinsically disordered proteins and their complexes with ligands: Kinetically trapped states during transfer from solution to the gas phase

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Exploring the Conformations and Binding Location of HMGA2·DNA Complexes Using Ion Mobility Spectrometry and 193 nm Ultraviolet Photodissociation Mass Spectrometry

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Experimental Characterization of Fuzzy Protein Assemblies: Interactions of Paramyxoviral NTAIL Domains With Their Functional Partners

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The Disordered Cellular Multi-Tasker WIP and Its Protein–Protein Interactions: A Structural View

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A “spindle and thread” mechanism unblocks p53 translation by modulating N-terminal disorder

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Structural and dynamical insights into SilE silver binding from combined analytical probes

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Improved Methods for Recording Accurate Collision Cross Sections Using Cyclic Ion Mobility-Mass Spectrometry

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Role of hydrophobic residues for the gaseous formation of helical motifs

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Characterization of Intrinsically Disordered Proteins in Healthy and Diseased States by Nuclear Magnetic Resonance

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Nanopipettes Enable Native Mass Spectrometry Studies of the Intrinsically Disordered Protein α-Synuclein in Biochemical Buffers

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An ALS ‐associated mutation in the C‐terminal α‐helix of TDP ‐43 uncouples condensate formation and amyloid assembly

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The Rise of Trapped Ion Mobility Spectrometry: Principles, Applications, and Recent Developments

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Methods for measuring structural disorder in proteins

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Overview Update: Computational Prediction of Intrinsic Disorder in Proteins

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Screening apo‐SOD1 conformation stabilizers from natural flavanones using native ion mobility mass spectrometry and fluorescence spectroscopy methods

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HyRes: Accurate Physics-Based Simulation of Dynamic Protein Structures and Interactions in Complex Environments at ScalePreprint

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A blurry view of fuzzy objects: on the roles of low-resolution structural techniques in discovery and early characterization of intrinsically disordered proteins

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Ion mobility mass spectrometry unveils conformational effects of drug lead EPI ‐001 on the intrinsically disordered N ‐terminal domain of the androgen receptor

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Ion Mobility Mass Spectrometry Measures the Conformational Landscape of p27 and its Domains and how this is Modulated upon Interaction with Cdk2/cyclin A

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Buffer-dependent conformational dynamics of α-synuclein revealed by nanopipette electrospray ionisation ion mobility mass spectrometryPreprint

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Mass spectrometry structural analysis of intrinsically disordered phosphoproteins

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Native Mass Spectrometry of BRD4 Bromodomains Linked to a Long Disordered Region

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Monitoring Conformational Changes of Lysozyme–Polyelectrolyte Complexes Using Trapped Ion Mobility-Mass Spectrometry (IM-MS)

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Protonation State-Induced Unfolding of Protein Secondary Structure in the Gas Phase

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Is synuclein aggregation a derived or ancestral trait? Ancestral sequence reconstruction uncovers stepwise evolution of synuclein aggregationPreprint

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Ion Mobility-Mass Spectrometry for Macromolecule Analysis

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The Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase Through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt-Bridge FormationPreprint

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Light-triggered conformational changes of an animal-like cryptochrome tracked by native time-resolved IMS-MSPreprint

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Molecular mechanisms of folding of intrinsically disordered proteins

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Caractérisation d’une famille de protéines intrinsèquement désordonnées, les syndécans

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Étude de la conformation et de la dynamique conformationnelle de molécules biologiques en phase gazeuse

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Intrinsic disorder in proteins: a challenge for (un)structural biology met by ion mobility–mass spectrometry

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Structural Proteomics Methods to Interrogate the Conformations and Dynamics of Intrinsically Disordered Proteins

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The Use of Mass Spectrometry to Examine IDPs: Unique Insights and Caveats

Stuchfield, D., France, A. P., Migas, L. G., Thalhammer, A., Bremer, A., Bellina, B., & Barran, P. E. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.09.038 · Cited by 15 · see citing works

Mass spectrometry methods for intrinsically disordered proteins

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Resolving intrinsically disordered proteins of the cancer genome with ion mobility mass spectrometry

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