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Cited by 11Escherichia coli research studiesGastrointestinal motility and disordersNitric Oxide and Endothelin Effects

Effects of nitric oxide in 5-hydroxytryptamine-, cholera toxin-, enterotoxigenic Escherichia coli- and Salmonella Typhimurium-induced secretion in the porcine small intestine

Grøndahl, Marie Louise, Unmack, Martin Andreas, Ragnarsdóttir, Helga Berglind, Hansen, Mark Berner, Olsen, John Elmerdahl, Skadhauge, Erik·2005·Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
DOI 10.1016/j.cbpb.2005.07.001
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Abstract

The effects of nitric oxide (NO) in the secretory response to the endogenous secretagogue 5-hydroxytryptamine (5-HT), the enterotoxins heat-labile enterotoxigenic Escherichia coli (ETEC) toxin (LT) and cholera toxin (CT), and various cultures of ETEC and Salmonella serotype Typhimurium in the porcine small intestine (Sus scrofa) were investigated. In anaesthetized pigs, jejunal tied-off loops were instilled with 5-HT, LT, CT, various cultures of ETEC or S. Typhimurium. Pigs were given intravenously isotonic saline or isotonic saline containing the NO synthase inhibitor, Nomega-nitro-L-arginine methyl ester (L-NAME). L-NAME significantly induced an increased fluid accumulation in loops induced by 5-HT, ETEC and stn-mutated S. Typhimurium. Fluid accumulation in loops instilled with wild-type S. Typhimurium was increased by L-NAME, although not significantly, while there was no effect on fluid accumulation induced by an invH-mutated isogenic strain. No significant effect of L-NAME was observed on the fluid accumulation induced by the purified enterotoxins LT and CT. The results also demonstrated a relatively large difference in the ability to induce fluid accumulation between the bacteria strains. Diastolic, systolic and mean blood pressures were significantly increased and the body temperature was significantly decreased in groups of pigs treated with L-NAME. In conclusion, the results suggest that NO has a proabsorptive effect in the intact porcine jejunum and is involved in the systemic vascular tone.

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  • As a consequence, serotonin receptors on enterocytes and on intrinsic and extrinsic primary nerve endings are activated in a paracrine fashion.

    “As a consequence, serotonin receptors on enterocytes and on intrinsic and extrinsic, primary nerve endings are activated in a paracrine fashion.63,64”

    From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [64]

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Authors
Grøndahl, M. L., Unmack, M. A., Ragnarsdóttir, H. B., Hansen, M. B., Olsen, J. E., & Skadhauge, E.
Affiliations
Bispebjerg Hospital (DK)
Corresponding author
Skadhauge, Erik
ORCID
Venue
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
Publisher
Elsevier BV
Published
2005-08
Volume
141
Issue
4
Pages
476-484
ISSN
1095-6433 (ISSN-L)
DOI
10.1016/j.cbpb.2005.07.001
OpenAlex
W2073799474
Cited by
11
References
60
Citations by year
2025: 1 · 2023: 1 · 2020: 2 · 2015: 1 · 2012: 1
FWCI
0.80
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
LEO Fondet
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
nitric oxide, intestinal secretion, serotonin, cholera toxin, heat-labile enterotoxin, enterotoxigenic Escherichia coli, Salmonella typhimurium, L-NAME, nitric oxide synthase inhibition, jejunum, blood pressure, body temperature
MeSH terms
Animals, Anti-Infective Agents, Blood Pressure, Body Temperature, Cholera Toxin, Escherichia coli, Female, Intestine, Small, Mutation, Neurons, Nitric Oxide, Salmonella Infections, Salmonella typhimurium, Serotonin, Swine, Time Factors, Nitric Oxide Synthase, NG-Nitroarginine Methyl Ester, Protein Isoforms

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