The role of serotonin in intestinal luminal sensing and secretion
Abstract
This mini‐review addresses the role of the neuroendocrine substance serotonin (5‐hydroxytryptamine, 5‐HT) in intestinal luminal sensing and secretion. Intestinal sensory neurones are activated by several mechanisms, in particular following stimulation of ‘specialized’ cells in the mucosa. These specialized cells are the enteroendocrine cells, which contain a wide variety of neuroendocrine transmitters. One of these enteroendocrine cells is the enterochromaffin (EC) cell, which is present throughout the intestines and contains large amounts of serotonin, predominantly in the duodenum in humans. The EC cells act as mucosal sensory transducers and secrete serotonin in response to various physiological and pathological luminal stimuli. Following release, serotonin participates in several mucosal protecting processes, one being secretion. Serotonin stimulates active ion, mucus and fluid secretion. Epithelial 5‐HT 2 receptors and neuronal 5‐HT 1P , 5‐HT 3 and 5‐HT 4 receptors mediate the secretory effect of serotonin. A transmembrane serotonin transporter terminates epithelial serotonergic signalling. The transient receptor potential ion channel family is important for processing intestinal luminal sensory signalling. Accumulating evidence suggests a significant interaction between serotonin and one of the transient receptor potential ion channels, the capsaicin‐sensitive transient receptor potential vanilloid type 1. Accordingly, EC cells, serotonergic receptors and transporter(s), and transient receptor potential vanilloid type‐1 ion channels are all explored as pharmacological targets for treatment of some intestinal functional disorders.
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Enterochromaffin cells express a wide variety of receptors, including serotonin receptors, the pituitary adenylate-cyclase-activating peptide receptor, the α-adrenergic receptor, the β-adrenergic receptor, the cholinergic receptor, the corticotropin-releasing hormone receptor and the γ-aminobutyric acid receptor.
“Enterochromaffin cells also express a wide variety of receptors, including serotonin receptors, the pituitary adenylate-cyclase-activating peptide receptor, the α-adrenergic receptor, the β-adrenergic receptor, the cholinergic receptor, the corticotropin-releasing hormone receptor and the γ-aminobutyric acid receptor.59”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [59]
Cites
1 retracted
Zhu, J., Wu, X., Owyang, C., & Li, Y. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0431k.x · Cited by 226 · see citing works
RetractedGershon, M. D., & Tack, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.002 · Cited by 1,563 · see citing works
Kararli, T. T. (1995) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2510160502 · Cited by 1,461 · see citing works
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155 · see citing works
Coates, M. D., Mahoney, C. R., Linden, D. R., Sampson, J. E., Chen, J. C., Blaszyk, H., Crowell, M. D., Sharkey, K. A., Gershon, M. D., & Mawe, G. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.013 · Cited by 761 · see citing works
Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin
Allen, A., & Flemström, G. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00102.2004 · Cited by 616 · see citing works
Endocrine cells in human intestine: an immunocytochemical study
Sjölund, K., Sandén, G., Håkanson, R., & Sundler, F. (1983) · Gastroenterology · doi:10.1016/s0016-5085(83)80080-8 · Cited by 520 · see citing works
Intestinal ion transport and the pathophysiology of diarrhea
Field, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18326 · Cited by 475 · see citing works
Intestinal ion transport and the pathophysiology of diarrhea
Field, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318326 · Cited by 468 · see citing works
Review article: roles played by 5‐hydroxytryptamine in the physiology of the bowel
Gershon, M. D. (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00002.x-i2 · Cited by 465 · see citing works
Crist, J. R. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90462-3 · Cited by 432 · see citing works
5-HT Receptor Classification and Nomenclature: Towards a Harmonization with the Human Genome
Hoyer, D., & Martin, G. B. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00036-1 · Cited by 415 · see citing works
Tissue Distribution Profiles of the Human TRPM Cation Channel Family
Fonfría, E., Murdock, P. R., Cusdin, F. S., Benham, C. D., Kelsell, R. E., & McNulty, S. (2006) · Journal of Receptors and Signal Transduction · doi:10.1080/10799890600637506 · Cited by 367 · see citing works
Vanilloid receptor 1 immunoreactivity in inflamed human bowel
Yiangou, Y., Facer, P., Dyer, N., Chan, C., Knowles, C. H., Williams, N. S., & Anand, P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04503-7 · Cited by 360 · see citing works
Fundamentals of neurogastroenterology
Wood, J. D., Alpers, D. H., & Andrews, P. L. R. (1999) · Gut · doi:10.1136/gut.45.2008.ii6 · Cited by 311 · see citing works
Gastrointestinal food hypersensitivity: Basic mechanisms of pathophysiology
Crowe, S. E., & Perdue, M. H. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90047-3 · Cited by 310 · see citing works
Bearcroft, C. P., Perrett, D. I., & Farthing, M. J. G. (1998) · Gut · doi:10.1136/gut.42.1.42 · Cited by 303 · see citing works
The gut as the largest endocrine organ in the body
Ahlman, H. K., & Nilsson, O. (2001) · Annals of Oncology · doi:10.1093/annonc/12.suppl_2.s63 · Cited by 256 · see citing works
Neurohumoral control of gastrointestinal motility
Hansen, M. (2003) · Physiological Research · doi:10.33549/physiolres.930255 · Cited by 246 · see citing works
Self-citationManagement of infectious diarrhoea
Casburn-Jones, A. C., & Farthing, M. J. G. (2004) · Gut · doi:10.1136/gut.2003.022103 · Cited by 244 · see citing works
Impaired Proximal Duodenal Mucosal Bicarbonate Secretion in Patients with Duodenal Ulcer
Isenberg, J. I., Selling, J. A., Hogan, D. L., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702123160704 · Cited by 216 · see citing works
5-HT 7 receptors: current knowledge and future prospects
Vanhoenacker, P., Haegeman, G., & Leysen, J. E. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01432-7 · Cited by 211 · see citing works
Magro, F., Vieira‐Coelho, M. A., Fraga, S., Serrão, P., Veloso, F. T., Ribeiro, T., & Soares-da-Silva, P. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1013256629600 · Cited by 206 · see citing works
Wheatcroft, J., Wakelin, D., Smith, A., Mahoney, C. R., Mawe, G., & Spiller, R. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00719.x · Cited by 205 · see citing works
Review article: intestinal serotonin signalling in irritable bowel syndrome
Mawe, G. M., Coates, M. D., & Moses, P. L. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02858.x · Cited by 205 · see citing works
Luminal amino acid sensing in the rat gastric mucosa
Uneyama, H., Niijima, A., Gabriel, A. S., & Torii, K. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00587.2005 · Cited by 199 · see citing works
The Enteric Nervous System I: Organisation and Classification
Hansen, M. B. (2003) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2003.t01-1-920301.x · Cited by 182 · see citing works
Self-citationThe treatment of functional dyspepsia with red pepper
Bortolotti, M., Coccia, G., Grossi, G., & Miglioli, M. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01280.x · Cited by 178 · see citing works
I. Receptors on visceral afferents
Kirkup, A. J., Brunsden, A. M., & Grundy, D. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.5.g787 · Cited by 174 · see citing works
Karamanolis, G. P., Caenepeel, P., Arts, J., & Tack, J. F. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.019 · Cited by 168 · see citing works
Bubenik, G. A. (2001) · Neurosignals · doi:10.1159/000046903 · Cited by 161 · see citing works
Expression of 5-HT3 receptors in the rat gastrointestinal tract
Glatzle, J., Sternini, C., Robin, C., Zittel, T. T., Wong, H. C., Reeve, J. R., & Raybould, H. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.34245 · Cited by 156 · see citing works
Ponti, F. D., & Tonini, M. (2001) · Drugs · doi:10.2165/00003495-200161030-00001 · Cited by 147 · see citing works
Gastroduodenal Mucosal Alkaline Secretion and Mucosal Protection
Flemström, G., & Isenberg, J. I. (2001) · Physiology · doi:10.1152/physiologyonline.2001.16.1.23 · Cited by 143 · see citing works
Regulation of serotonin release from the intestinal mucosa
Racké, K., & Schwörer, H. (1991) · Pharmacological Research · doi:10.1016/s1043-6618(05)80101-x · Cited by 141 · see citing works
Sugiuar, T., Bielefeldt, K., & Gebhart, G. F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2639-04.2004 · Cited by 135 · see citing works
Gebauer, A., Merger, M., & Kilbinger, H. J. (1993) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00169258 · Cited by 130 · see citing works
Lee, K., Demarchi, B., Demedts, I., Sifrim, D. A., Raeymaekers, P., & Tack, J. F. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.30822.x · Cited by 123 · see citing works
Local secretion of corticotropin-releasing hormone by enterochromaffin cells in human colon
Kawahito, Y., Sano, H., Kawata, M., Yuri, K., Mukai, S., Yamamura, Y., Kato, H., Chrousos, G. P., Wilder, R. L., & Kondo, M. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90743-9 · Cited by 122 · see citing works
D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells
Kim, M., Cooke, H. J., Javed, N., Carey, H. V., Christofi, F. L., & Raybould, H. E. (2001) · Gastroenterology · doi:10.1053/gast.2001.29567 · Cited by 120 · see citing works
The Enteric Nervous System II: Gastrointestinal Functions
Hansen, M. B. (2003) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2003.920601.x · Cited by 117 · see citing works
Self-citationMiwa, J., Echizen, H., Matsueda, K., & Umeda, N. (2001) · Digestion · doi:10.1159/000051888 · Cited by 116 · see citing works
Gut pain and hyperalgesia induced by capsaicin: a human experimental model
Drewes, A. M., Schipper, K., Dimcevski, G. G., et al. (2003) · Pain · doi:10.1016/s0304-3959(03)00039-3 · Cited by 112 · see citing works
The Functional Characterization of Normal and Neoplastic Human Enterochromaffin Cells
Modlin, I. M., Kidd, M. S., Pfragner, R., Eick, G. N., & Champaneria, M. C. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0110 · Cited by 108 · see citing works
Hypersensitivity for capsaicin in patients with functional dyspepsia
Hammer, J., Führer, M., Pipal, L., & Matiasek, J. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00997.x · Cited by 107 · see citing works
Ohta, T., Ikemi, Y., Murakami, M., Imagawa, T., Otsuguro, K., & Ito, S. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.112250 · Cited by 107 · see citing works
The pharmacology of gastrointestinal nociceptive pathways
Blackshaw, L. A. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00211-4 · Cited by 106 · see citing works
Hogan, D., Rapier, R. C., Dreilinger, A. D., Koss, M., Basuk, P. M., Weinstein, W. M., Nyberg, L., & Isenberg, J. I. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8608879 · Cited by 100 · see citing works
Serotonin Excites Neurons in the Human Submucous Plexus via 5-HT3 Receptors
Michel, K., Zeller, F., Langer, R., Nekarda, H., Krueger, D., Dover, T. J., Brady, C., Barnes, N. M., & Schemann, M. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.005 · Cited by 93 · see citing works
Sensory mechanisms: transmitters, modulators and reflexes
Raybould, H. E., Cooke, H. J., & Christofi, F. L. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1743-3150.2004.00477.x · Cited by 90 · see citing works
Kellum, J. M., Albuquerque, F. C., Stoner, M. C., & Harris, R. P. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.3.g515 · Cited by 84 · see citing works
Caenorhabditis elegansTRPV ion channel regulates 5HT biosynthesis in chemosensory neurons
Zhang, S., Sokolchik, I., Blanco, G., & Sze, J. Y. (2004) · Development · doi:10.1242/dev.01047 · Cited by 78 · see citing works
Serotonin and its implication for the management of irritable bowel syndrome.
Gershon (2003) · PubMed · Cited by 75 · see citing works
Release of Immunoreactive Serotonin Following Acid Perfusion of the Duodenum
Kellum, J. M., & Jaffe, B. M. (1976) · Annals of Surgery · doi:10.1097/00000658-197611000-00018 · Cited by 66 · see citing works
Bearcroft, C. P., Andrè, E., & Farthing, M. J. G. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.d01-1389.x · Cited by 66 · see citing works
Role of nerves in enteric infection: Table 1
Spiller, R. E. (2002) · Gut · doi:10.1136/gut.51.6.759 · Cited by 64 · see citing works
Signal Transduction Pathways for Serotonin as an Intestinal Secretagogue
Hansen, M. B., & Skadhauge, E. (1997) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/s0300-9629(97)00085-6 · Cited by 64 · see citing works
Self-citation5-hydroxytryptamine release into human jejunum by cholera toxin.
Bearcroft, C. P., Perrett, D. I., & Farthing, M. J. G. (1996) · Gut · doi:10.1136/gut.39.4.528 · Cited by 63 · see citing works
Schwörer, H., & Ramadori, G. P. (1998) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005206 · Cited by 58 · see citing works
L-Arginine, nitric oxide, and intestinal secretion: studies in rat jejunum in vivo.
Mourad, F. H., O'Donnell, L. J., Andrè, E., et al. (1996) · Gut · doi:10.1136/gut.39.4.539 · Cited by 58 · see citing works
Christofi, F. L., Kim, M., Wunderlich, J. E., Xue, J., Suntres, Z., Cardounel, A. J., Javed, N., Yu, J., Grants, I. S., & Cooke, H. J. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.070 · Cited by 49 · see citing works
The Neuroendocrine System of the Gut
Sundler, F., Bouttcher, G., Ekblad, E., et al. (1989) · Acta Oncologica · doi:10.3109/02841868909111198 · Cited by 45 · see citing works
Budhoo, M., Harris, R. P., & Kellum, J. M. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00752-0 · Cited by 44 · see citing works
Burleigh, D. E., & Borman, R. A. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90943-c · Cited by 44 · see citing works
Gastrointestinal pain in functional bowel disorders: sensory neurons as novel drug targets
Holzer, P. D. (2004) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.8.2.107 · Cited by 44 · see citing works
Flemström, G., & Sjöblom, M. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00093.2005 · Cited by 42 · see citing works
Effect of 5-hydroxytryptamine on duodenal mucosal bicarbonate secretion in mice
Tuo, B., & Isenberg, J. I. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01045-x · Cited by 41 · see citing works
Meyer, T., & Brinck, U. (1999) · Digestion · doi:10.1159/000007590 · Cited by 40 · see citing works
TRP channels as therapeutic targets: hot property, or time to cool down?
Hicks, G. A. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00823.x · Cited by 40 · see citing works
van Lelyveld, N., ter Linde, J., Schipper, M. E. I., et al. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00891.x · Cited by 39 · see citing works
A 5-HT2 Receptor Mediates Serotonin-Induced Electrolyte Transport in Rat Left Colon
Siriwardena, A. K., & Kellum, J. M. (1993) · Journal of Surgical Research · doi:10.1006/jsre.1993.1149 · Cited by 37 · see citing works
Kaunitz, J. D., & Akiba, Y. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.00041.x · Cited by 37 · see citing works
Säfsten, B., Sjöblom, M., & Flemström, G. (2006) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520600641480 · Cited by 36 · see citing works
Gustafsson, B. I., Bakke, I., Tømmerås, K. A., et al. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520500331281 · Cited by 35 · see citing works
New aspects of the pathophysiology and treatment of secretory diarrhoea.
Hansen, M. B., & Skadhauge, E. (1995) · PubMed · Cited by 35 · see citing works
Self-citationImmunocytochemistry of serotonin-containing nerves in the human gut
Kurian, S. S., Ferri, G., Mey, J. D., et al. (1983) · Histochemistry and Cell Biology · doi:10.1007/bf00496204 · Cited by 34 · see citing works
Glišić, R., Koko, V., Todorović, V., et al. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.04.019 · Cited by 34 · see citing works
Sokolchik, I., Tanabe, T., Baldi, P., & Sze, J. Y. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3107-04.2005 · Cited by 34 · see citing works
The role of the 5-HT4 receptor in Cl− secretion in human jejunal mucosa
Budhoo, M., Harris, R. P., & Kellum, J. M. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00474-8 · Cited by 32 · see citing works
Fujimiya, M., Yamamoto, H., & Kuwahara, A. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.4.g731 · Cited by 30 · see citing works
Is nitric oxide involved in 5-HT-induced fluid secretion in the gut?
Kadowaki, M., Gershon, M. D., & Kuwahara, A. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00126-x · Cited by 29 · see citing works
Nitric oxide is a neurotransmitter in the chloride secretory response to serotonin in rat colon
Stoner, M. C., Scherr, A. M., Lee, J. A., et al. (2000) · Surgery · doi:10.1067/msy.2000.107608 · Cited by 28 · see citing works
Functional CRF receptors in BON cells stimulate serotonin release
von Mentzer, B., Murata, Y., Ahlstedt, I., Lindström, E., & Martı́nez, V. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.11.019 · Cited by 27 · see citing works
Characterization of 5‐hydroxytryptamine receptors mediating mucosal secretion in guinea‐pig ileum
Johnson, P. J., Bornstein, J. C., Furness, J. B., et al. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14878.x · Cited by 27 · see citing works
Serotonin‐Induced Short‐Circuit Current in Pig Jejunum
Hansen, M. B., Thorbøll, J. E., Christensen, P., et al. (1994) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.1994.tb00073.x · Cited by 26 · see citing works
Self-citationDistribution of serotonin-immunoreactive gut endocrine cells in chicks at hatching
Rawdon, B. B., & Andrew, A. (1994) · Histochemistry and Cell Biology · doi:10.1007/bf00269012 · Cited by 25 · see citing works
Smith, A. J., Chappell, A. E., Buret, A. G., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-6391com · Cited by 24 · see citing works
Kilkens, T. O. C., Honig, A., Rozendaal, N., van Nieuwenhoven, M. A., & Brummer, R. J. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01388.x · Cited by 24 · see citing works
Grøndahl, M. L., Hansen, M. B., Larsen, I. E., et al. (1996) · Journal of Comparative Physiology B · doi:10.1007/bf00264635 · Cited by 23 · see citing works
Self-citationBeubler, E., & Schirgi‐Degen, A. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)85417-9 · Cited by 23 · see citing works
Miceli, P. C., Morris, G. P., MacNaughton, W. K., & Vanner, S. J. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00037.2001 · Cited by 21 · see citing works
Acute tryptophan depletion slows gastric emptying in females
van Nieuwenhoven, M. A., Valks, S. D. M., Sobczak, S., Riedel, W. J., & Brummer, R. J. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20031055 · Cited by 20 · see citing works
Intestinal 5-Hydroxytryptamine and Mast Cell Infiltration in Rat Experimental Colitis
Magro, F., Fraga, S., Azevedo, I., et al. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-3161-8 · Cited by 19 · see citing works
Budhoo, M., & Kellum, J. M. (1994) · PubMed · Cited by 18 · see citing works
Munck, L. K., Eskerod, O., Hansen, M. B., et al. (1994) · Gut · doi:10.1136/gut.35.5.637 · Cited by 17 · see citing works
Self-citationChemosensitivity of the human gastrointestinal tract in health and in disease
Tack, J. F. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00933.x · Cited by 17 · see citing works
Grøndahl, M. L., Thorbøll, J. E., Hansen, M. B., et al. (1998) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.1998.tb00840.x · Cited by 16 · see citing works
Self-citationFunctional Characterization of Serotonin Receptor Subtypes in Human Duodenal Secretion
Engelmann, B. E., Bindslev, N., Poulsen, S. S., et al. (2006) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2006.pto_262.x · Cited by 15 · see citing works
Protein kinase C potentiates cAMP-stimulated mouse duodenal mucosal bicarbonate secretion in vitro
Tuo, B., Chow, J. Y. C., Barrett, K. E., et al. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00251.2003 · Cited by 14 · see citing works
Day, J. D., King, B. N., Haque, S. M., & Kellum, J. M. (2005) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2005.07.012 · Cited by 14 · see citing works
Serotonin receptors for chloride secretion in hen colon
Hansen, M. B., & Bindslev, N. (1989) · Comparative Biochemistry and Physiology Part C Comparative Pharmacology · doi:10.1016/0742-8413(89)90166-7 · Cited by 12 · see citing works
Self-citationFujimiya, M., Maeda, T., & Kimura, H. (1991) · Histochemistry · doi:10.1007/bf00266770 · Cited by 11 · see citing works
Unmack, M. A., Hansen, M. B., Grøndahl, M. L., et al. (2001) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1046/j.1439-0442.2001.00348.x · Cited by 11 · see citing works
Self-citationGrøndahl, M. L., Unmack, M. A., Ragnarsdóttir, H. B., Hansen, M. B., Olsen, J. E., & Skadhauge, E. (2005) · Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology · doi:10.1016/j.cbpb.2005.07.001 · Cited by 11 · see citing works
Self-citationInflammatory Mediators Influencing Submucosal Secretory Reflexes
Frieling, T., Weber, E., & Schemann, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05229.x · Cited by 9 · see citing works
Hardcastle, J., & Hardcastle, P. T. (1997) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1997.tb06054.x · Cited by 9 · see citing works
Townsend, D., Casey, M. A., & Brown, D. R. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.07.023 · Cited by 6 · see citing works
Tropisetron and Octreotide Reduce Serotonin‐Induced Fluid Hypersecretion in Pig Jejunum
Hansen, M. B. (1995) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1995.tb00119.x · Cited by 4 · see citing works
Self-citationIV. Visceral afferents: an update
Raybould, H. E. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00123.2003 · Cited by 4 · see citing works
Cash, B. D., & Chey, W. D. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.10.018 · Cited by 4 · see citing works
Mechanisms of glucose sensing in enteric neurons
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Constantinescu, M. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-27592-5 · Cited by 1 · see citing works
Recent concepts in the dumping syndrome.
Drapanas, T. (1969) · PubMed · Cited by 1 · see citing works
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Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works
“Enterochromaffin cells also express a wide variety of receptors, including serotonin receptors, the pituitary adenylate-cyclase-activating peptide receptor, the α-adrenergic receptor, the β-adrenergic receptor, the cholinergic receptor, the corticotropin-releasing hormone receptor and the γ-aminobutyric acid receptor”
The Intestinal Microenvironment and Functional Gastrointestinal Disorders
Barbara, G., Feinle-Bisset, C., Ghoshal, U. C., Santos, J., Vanner, S. J., Vergnolle, N., Zoetendal, E. G., & Quigley, E. M. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.028 · Cited by 335 · see citing works
Bosi, A., Banfi, D., Bistoletti, M., Giaroni, C., & Baj, A. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920928984 · Cited by 221 · see citing works
Diverse effects of gut-derived serotonin in intestinal inflammation
Shajib, M. S., Baranov, A., & Khan, W. I. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00414 · Cited by 109 · see citing works
Walentek, P., Bogusch, S., Thumberger, T., Vick, P., Dubaissi, E., Beyer, T., Blum, M., & Schweickert, A. (2014) · Development · doi:10.1242/dev.102343 · Cited by 61 · see citing works
- Authors
- Hansen, M. B., & Witte, A. ‐.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Hansen, M. Berner
- ORCID
- Hansen, M. Berner
- Venue
- Acta Physiologica
- Publisher
- Wiley
- Published
- 2008-07-08
- Volume
- 193
- Issue
- 4
- Pages
- 311-323
- ISSN
- 1748-1708 (ISSN-L)
- 1748-1716
- OpenAlex
- W2163418240
- Cited by
- 144
- References
- 113
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 11 · 2015: 8 · 2014: 4 · 2013: 7 · 2012: 9
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- serotonin, enterochromaffin cells, enteroendocrine cells, intestinal secretion, mucus secretion, ion secretion, serotonin receptors, serotonin transporter, TRPV1, TRP channels, therapeutic target
- MeSH terms
- Animals, Duodenum, Enterochromaffin Cells, Humans, Intestinal Mucosa, Neurons, Afferent, Receptors, Serotonin, Serotonin, Enteroendocrine Cells, TRPV Cation Channels, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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