Cited by 144Gastrointestinal motility and disordersIon Channels and ReceptorsNeuropeptides and Animal Physiology

The role of serotonin in intestinal luminal sensing and secretion

Hansen, M. Berner, Witte, A.‐B.·2008·Acta Physiologica

Abstract

This mini‐review addresses the role of the neuroendocrine substance serotonin (5‐hydroxytryptamine, 5‐HT) in intestinal luminal sensing and secretion. Intestinal sensory neurones are activated by several mechanisms, in particular following stimulation of ‘specialized’ cells in the mucosa. These specialized cells are the enteroendocrine cells, which contain a wide variety of neuroendocrine transmitters. One of these enteroendocrine cells is the enterochromaffin (EC) cell, which is present throughout the intestines and contains large amounts of serotonin, predominantly in the duodenum in humans. The EC cells act as mucosal sensory transducers and secrete serotonin in response to various physiological and pathological luminal stimuli. Following release, serotonin participates in several mucosal protecting processes, one being secretion. Serotonin stimulates active ion, mucus and fluid secretion. Epithelial 5‐HT 2 receptors and neuronal 5‐HT 1P , 5‐HT 3 and 5‐HT 4 receptors mediate the secretory effect of serotonin. A transmembrane serotonin transporter terminates epithelial serotonergic signalling. The transient receptor potential ion channel family is important for processing intestinal luminal sensory signalling. Accumulating evidence suggests a significant interaction between serotonin and one of the transient receptor potential ion channels, the capsaicin‐sensitive transient receptor potential vanilloid type 1. Accordingly, EC cells, serotonergic receptors and transporter(s), and transient receptor potential vanilloid type‐1 ion channels are all explored as pharmacological targets for treatment of some intestinal functional disorders.

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Crossref · 10.1111/j.1748-1716.2008.01870.x

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113 of 113 references verified0 citation errors · 0 not checkable

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  • Enterochromaffin cells express a wide variety of receptors, including serotonin receptors, the pituitary adenylate-cyclase-activating peptide receptor, the α-adrenergic receptor, the β-adrenergic receptor, the cholinergic receptor, the corticotropin-releasing hormone receptor and the γ-aminobutyric acid receptor.

    “Enterochromaffin cells also express a wide variety of receptors, including serotonin receptors, the pituitary adenylate-cyclase-activating peptide receptor, the α-adrenergic receptor, the β-adrenergic receptor, the cholinergic receptor, the corticotropin-releasing hormone receptor and the γ-aminobutyric acid receptor.59”

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Authors
Hansen, M. B., & Witte, A. ‐.
Affiliations
University of Copenhagen (DK)
Corresponding author
Hansen, M. Berner
Venue
Acta Physiologica
Publisher
Wiley
Published
2008-07-08
Volume
193
Issue
4
Pages
311-323
ISSN
  • 1748-1708 (ISSN-L)
  • 1748-1716
OpenAlex
W2163418240
Cited by
144
References
113
Citations by year
2026: 4 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 11 · 2015: 8 · 2014: 4 · 2013: 7 · 2012: 9
FWCI
2.08
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Physiologica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
serotonin, enterochromaffin cells, enteroendocrine cells, intestinal secretion, mucus secretion, ion secretion, serotonin receptors, serotonin transporter, TRPV1, TRP channels, therapeutic target
MeSH terms
Animals, Duodenum, Enterochromaffin Cells, Humans, Intestinal Mucosa, Neurons, Afferent, Receptors, Serotonin, Serotonin, Enteroendocrine Cells, TRPV Cation Channels, Rats

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