Cited by 76Lipid metabolism and disordersLipid metabolism and biosynthesisParaoxonase enzyme and polymorphisms

Vascular lipases, inflammation and atherosclerosis

Hasham, Sumera N., Pillarisetti, Sivaram·2006·Clinica Chimica Acta

Abstract

Members of the lipase family that include lipoprotein lipase, hepatic lipase and endothelial cell lipase play a central role in triglyceride and phospholipid hydrolysis. Because the site of action of these lipases is the endothelium, the endothelium is constantly exposed to products of lipolysis. These lipolysis products could elicit pro- or anti-inflammatory effects in endothelial as well as surrounding cells. These effects could be transient or long-term depending on the nutritional state. While lipolysis is per se anti-atherogenic due to its triglyceride lowering activity, it could also be pro-atherogenic due to prolonged exposure of endothelium to lipolysis products. In addition, lipoprotein lipase expressed in macrophages appears to be pro-atherogenic independent of plasma lipoproteins. In this review we summarize these pro- and anti-inflammatory consequences of lipolysis with respect to atherosclerosis.

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Crossref · 10.1016/j.cca.2006.04.020

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Authors
Hasham, S. N., & Pillarisetti, S.
Affiliations
  • Dr. Reddy's Laboratories (India) (IN)
  • Dr. Reddy's Laboratories (United States) (US)
Corresponding author
Pillarisetti, Sivaram
Venue
Clinica Chimica Acta
Publisher
Elsevier BV
Published
2006-10
Volume
372
Issue
1-2
Pages
179-183
ISSN
0009-8981 (ISSN-L)
OpenAlex
W2086222574
Cited by
76
References
39
Citations by year
2026: 1 · 2025: 5 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 5
FWCI
3.74
Type
journal article
Language
en
Open access
closed
Locations
  • Clinica Chimica Acta (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
lipoprotein lipase, hepatic lipase, endothelial lipase, lipolysis, phospholipid hydrolysis, inflammation, atherosclerosis, endothelium, atherogenicity
MeSH terms
Blood Vessels, Endothelium, Vascular, Humans, Inflammation, Lipase, Lipolysis, Liver, Macrophages, Atherosclerosis

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