The DOI matches its Crossref record; 211 of the 211 references it cites were found in a registry or an index.
Endocannabinoids and pregnancy.
Abstract
Acylethanolamides such as anandamide (AEA), and monoacylglycerols like 2-arachidonoylglycerol are endocannabinoids that bind to cannabinoid, vanilloid and peroxisome proliferator-activated receptors. These compounds, their various receptors, the purported membrane transporter(s), and related enzymes that synthesize and degrade them are collectively referred to as the "endocannabinoid system (ECS)". Poorly defined cellular and molecular mechanisms control the biological actions of the ECS. Over the last decade evidence has been emerging to suggest that the ECS plays a significant role in various aspects of human reproduction. In this review, we summarize our current understanding of this role especially the involvement of AEA and related ECS elements in regulating oogenesis, embryo oviductal transport, blastocyst implantation, placental development and pregnancy outcomes, and sperm survival, motility, capacitation and acrosome reaction. Additionally, the possibility that plasma and tissue AEA and other cannabinoids may represent reliable diagnostic markers of natural and assisted reproduction and pregnancy outcomes in women will be discussed.
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Metadata
- Authors
- Taylor, A. H., Amoako, A. A., Bambang, K., Karasu, T., Gebeh, A., Lam, P. M. W., Marzcylo, T. H., & Konje, J. C.
- Affiliations
- University of Leicester (GB)
- Corresponding author
- Konje, Justin C.
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 411
- Issue
- 13-14
- Pages
- 921-930
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W1969221886
- Cited by
- 89
- References
- 211
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 11 · 2023: 8 · 2022: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 8
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- endocannabinoid system, anandamide, 2-arachidonoylglycerol, pregnancy, oogenesis, embryo implantation, placental development, sperm capacitation, acrosome reaction, assisted reproduction, diagnostic biomarkers, cannabinoid receptors
- MeSH terms
- Animals, Blastocyst, Employment, Female, Gametogenesis, Humans, Embryo Implantation, Placenta, Pregnancy, Cannabinoid Receptor Modulators, Endocannabinoids
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