Cited by 89Cannabis and Cannabinoid ResearchReproductive System and PregnancyReproductive Biology and Fertility

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Endocannabinoids and pregnancy.

Taylor, Anthony H., Amoako, Akwasi A., Bambang, Katerina, Karasu, Tulay, Gebeh, Alpha, Lam, Patricia M.W., Marzcylo, Timothy H., Konje, Justin C.·2010·Clinica Chimica Acta

DOI 10.1016/j.cca.2010.03.012

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Abstract

Acylethanolamides such as anandamide (AEA), and monoacylglycerols like 2-arachidonoylglycerol are endocannabinoids that bind to cannabinoid, vanilloid and peroxisome proliferator-activated receptors. These compounds, their various receptors, the purported membrane transporter(s), and related enzymes that synthesize and degrade them are collectively referred to as the "endocannabinoid system (ECS)". Poorly defined cellular and molecular mechanisms control the biological actions of the ECS. Over the last decade evidence has been emerging to suggest that the ECS plays a significant role in various aspects of human reproduction. In this review, we summarize our current understanding of this role especially the involvement of AEA and related ECS elements in regulating oogenesis, embryo oviductal transport, blastocyst implantation, placental development and pregnancy outcomes, and sperm survival, motility, capacitation and acrosome reaction. Additionally, the possibility that plasma and tissue AEA and other cannabinoids may represent reliable diagnostic markers of natural and assisted reproduction and pregnancy outcomes in women will be discussed.

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“, [49]).”

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Authors: Taylor, A. H., Amoako, A. A., Bambang, K., Karasu, T., Gebeh, A., Lam, P. M. W., Marzcylo, T. H., & Konje, J. C.
Affiliations: University of Leicester (GB)
Corresponding author: Konje, Justin C.
ORCID: Taylor, Anthony H.
Amoako, Akwasi A.
Gebeh, Alpha
Lam, Patricia M.W.
Konje, Justin C.
Venue: Clinica Chimica Acta
Publisher: Elsevier BV
Published: 2010-07
Volume: 411
Issue: 13-14
Pages: 921-930
ISSN: 0009-8981 (ISSN-L)
DOI: 10.1016/j.cca.2010.03.012
OpenAlex: W1969221886
Cited by: 89
References: 211
Citations by year: 2026: 2 · 2025: 3 · 2024: 11 · 2023: 8 · 2022: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 8
FWCI: 1.05
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinica Chimica Acta (publishedVersion)
PubMed (publishedVersion)
Leicester Research Archive (University of Leicester) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: endocannabinoid system, anandamide, 2-arachidonoylglycerol, pregnancy, oogenesis, embryo implantation, placental development, sperm capacitation, acrosome reaction, assisted reproduction, diagnostic biomarkers, cannabinoid receptors
MeSH terms: Animals, Blastocyst, Employment, Female, Gametogenesis, Humans, Embryo Implantation, Placenta, Pregnancy, Cannabinoid Receptor Modulators, Endocannabinoids

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