Association between hypertriglyceridemia and protein oxidation and proinflammatory markers in normocholesterolemic and hypercholesterolemic individuals
Abstract
Background Although hypercholesterolemia is a well-established risk factor for coronary heart disease, evidence suggests that increased triglyceride (TG) concentrations are also an independent risk factor. TG concentrations >150mg/dl are observed nearly twice as often in subjects with atherosclerosis. We assessed the association between hypertriglyceridemia and protein oxidation and proinflammatory markers in normocholesterolemic and hypercholesterolemic individuals. Methods We included 127 volunteers enrolled in Cruz Alta, RS, Brazil. The patients were stratified based on total cholesterol and TG concentrations for analysis of associations with inflammation (high-sensitivity C-reactive protein - hs-CRP), endothelial dysfunction (nitric oxide - NOx) and oxidative stress (advanced oxidation protein products - AOPPs; ischemia-modified albumin - IMA). Correlations between variables were determined and multiple regression analysis was employed to investigate whether some variables correlate with TG concentrations. Results Hypertriglyceridemia was related to oxidative stress and proinflammatory markers in individuals independent of total cholesterol concentrations. Moreover, the results indicate a stronger association of tested biomarkers with TG concentrations than with total cholesterol. The results indicate a positive correlation between oxidative stress and TG concentrations in the sera of hypercholesterolemia subjects. AOPPs and IMA concentrations were associated with the pre…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Systemically, TRLs and their remnants have been linked to markers of low-grade inflammation, including hs-CRP, circulating cytokines such as IL-6 and TNF-α, and immune cell activation.
“Systemically, TRLs and their remnants have been linked to markers of low-grade inflammation, including hs-CRP, circulating cytokines such as IL-6 and TNF-α, and immune cell activation [22–28].”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [26]
Cites
Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Miller, M., Stone, N. J., Ballantyne, C., Bittner, V., Criqui, M. H., Ginsberg, H. N., Goldberg, A. C., Howard, W. J., Jacobson, M. S., Kris-Etherton, P. M., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182160726 · Cited by 1,871 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Natural Products with Antiplatelet Action
Hirsch, G. E., Nazario Viecili, P. R., de Almeida, A. S., Nascimento, S., Porto, F. G., Otero, J., Schmidt, A., da Silva, B., Parisi, M. M., & Klafke, J. Z. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666161123151611 · Cited by 57 · see citing works
Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets
ZHOU, F.-H., DENG, X.-J., CHEN, Y.-Q., YA, F.-L., ZHANG, X.-D., SONG, F., LI, D., & YANG, Y. (2017) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.63.237 · Cited by 23 · see citing works
Targeting triglycerides for cardiovascular risk reduction
Maiorca, C., Tramontano, D., Di Costanzo, A., & D’Erasmo, L. (2026) · Internal and Emergency Medicine · doi:10.1007/s11739-026-04383-1
- Authors
- Klafke, J. Z., Porto, F. G., Batista, R., Bochi, G. V., Moresco, R. N., da Luz, P. L., & Viecili, P. R. N.
- Affiliations
- University of Cruz Alta (BR)
- Universidade Federal de Santa Maria (BR)
- Corresponding author
- Klafke, Jonatas Zeni
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 448
- Pages
- 50-57
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W777427283
- Cited by
- 28
- References
- 1
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 1 · 2017: 6 · 2016: 3
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Cardiologia de Cruz Alta (ICCA)
- Programa Institucional de Bolsas de Iniciação Científica – (PIBIC)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- hypertriglyceridemia, protein oxidation, oxidative stress, pro-inflammatory markers, hypercholesterolemia, advanced oxidation protein products, ischemia-modified albumin, high-sensitivity C-reactive protein, nitric oxide, endothelial dysfunction, triglycerides, total cholesterol, atherosclerosis risk
- MeSH terms
- C-Reactive Protein, Cholesterol, Female, Humans, Hypercholesterolemia, Inflammation, Male, Middle Aged, Nitric Oxide, Regression Analysis, Triglycerides, Biomarkers, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
