Cited by 23Platelet Disorders and TreatmentsPhytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative Stress

Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

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ZHOU, Fang-Hang, DENG, Xiu-Juan, CHEN, Yan-Qiu, YA, Fu-Li, ZHANG, Xian-Dan, SONG, Fenglin, LI, Dan, YANG, Yan·2017·Journal of Nutritional Science and Vitaminology

Abstract

Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD40L, 5-HT, RANTES and TGF-β1 in gel-filtered platelets, in addition to attenuating serum PF4 and β-TG levels in mice fed high-fat diets. These results provide evidence that Cy-3-g protects against thrombosis and CVDs by inhibiting purified platelet granule release in vivo.

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Authors
ZHOU, F.-H., DENG, X.-J., CHEN, Y.-Q., YA, F.-L., ZHANG, X.-D., SONG, F., LI, D., & YANG, Y.
Affiliations
  • Department of Nutrition, School of Public Health, Sun Yat-Sen University
  • Guangzhou Women and Children Medical Centre
  • Guangdong Pharmaceutical University (CN)
  • Sun Yat-sen University (CN)
Venue
Journal of Nutritional Science and Vitaminology
Published
2017
Volume
63
Issue
4
Pages
237-243
ISSN
  • 0301-4800 (ISSN-L)
  • 1881-7742
OpenAlex
W2764229056
Cited by
23
References
42
Citations by year
2025: 1 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4
FWCI
1.69
Type
journal article
Language
en
Open access
Locations
  • Journal of Nutritional Science and Vitaminology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81573145, 81372978)
Topics
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
cyanidin-3-glucoside, anthocyanins, platelet granule secretion, high-fat diet, cardiovascular disease, thrombosis, P-selectin, CD40 ligand, serotonin, RANTES, TGF-β1, platelet factor 4, beta-thromboglobulin, serum lipids, dietary supplementation
MeSH terms
Animals, Anthocyanins, beta-Thromboglobulin, Blood Platelets, Cardiovascular Diseases, Diet, Glucosides, Lipids, Male, Mice, Inbred C57BL, Platelet Factor 4, Serotonin, Platelet Activation, Chemokine CCL5, Dietary Supplements, Secretory Vesicles, Mice, Transforming Growth Factor beta1, Diet, High-Fat

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