Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets
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Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD40L, 5-HT, RANTES and TGF-β1 in gel-filtered platelets, in addition to attenuating serum PF4 and β-TG levels in mice fed high-fat diets. These results provide evidence that Cy-3-g protects against thrombosis and CVDs by inhibiting purified platelet granule release in vivo.
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Polyphenols such as chlorogenic acid or the anthocyanin cyanidin-3-glucoside interrupt thrombin-induced platelet aggregation.
“In vitro and in vivo studies showed that polyphenols such as chlorogenic acid or the anthocyanin cyanidin-3-glucoside interrupt thrombin-induced platelet aggregation [60,61].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [61]
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Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288 · see citing works
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- Authors
- ZHOU, F.-H., DENG, X.-J., CHEN, Y.-Q., YA, F.-L., ZHANG, X.-D., SONG, F., LI, D., & YANG, Y.
- Affiliations
- Department of Nutrition, School of Public Health, Sun Yat-Sen University
- Guangzhou Women and Children Medical Centre
- Guangdong Pharmaceutical University (CN)
- Sun Yat-sen University (CN)
- Venue
- Journal of Nutritional Science and Vitaminology
- Published
- 2017
- Volume
- 63
- Issue
- 4
- Pages
- 237-243
- ISSN
- 0301-4800 (ISSN-L)
- 1881-7742
- OpenAlex
- W2764229056
- Cited by
- 23
- References
- 42
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Nutritional Science and Vitaminology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81573145, 81372978)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- cyanidin-3-glucoside, anthocyanins, platelet granule secretion, high-fat diet, cardiovascular disease, thrombosis, P-selectin, CD40 ligand, serotonin, RANTES, TGF-β1, platelet factor 4, beta-thromboglobulin, serum lipids, dietary supplementation
- MeSH terms
- Animals, Anthocyanins, beta-Thromboglobulin, Blood Platelets, Cardiovascular Diseases, Diet, Glucosides, Lipids, Male, Mice, Inbred C57BL, Platelet Factor 4, Serotonin, Platelet Activation, Chemokine CCL5, Dietary Supplements, Secretory Vesicles, Mice, Transforming Growth Factor beta1, Diet, High-Fat
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