Cited by 57Platelet Disorders and TreatmentsMedicinal Plant ResearchAntiplatelet Therapy and Cardiovascular Diseases

Natural Products with Antiplatelet Action

Hirsch, Gabriela Elisa, Nazario Viecili, Paulo Ricardo, de Almeida, Amanda Spring, Nascimento, Sabrina, Porto, Fernando Garcez, Otero, Juliana, Schmidt, Aline, da Silva, Brenda +2 more·2017·Current Pharmaceutical Design

Abstract

BACKGROUND: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation. These mechanisms have been widely studied and discussed because they are inhibited by the use of medicinal plants in complementary and alternative medicine, thus reducing platelet aggregation. RESULTS: Of the main plants discussed in this review, which have antiplatelet activity, some include saffron, garlic, green tea, St. John's wort, ginger, ginkgo biloba, ginseng, and guavirova. These herbal medicines have phytochemical components, which are directly related to the antiplatelet activity of the plant, such as flavonoids, curcumins, catechins, terpenoids, polyphenols, and saponins. While the majority of the medicinal plants mentioned here were native to the Asian continents, some are distributed worldwide, and found to a smaller extent throughout the American continent, European continent, Mediterranean, African continent, and the Middle East. CONCLUSION: This review showed that several plants and/or compounds exhibit anti-platelet activity, and are therefore potential research targets for developing drugs to treat diseases related to aggregation disorders.

Integrity signals

Registry

Crossref · 10.2174/1381612823666161123151611

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186 of 186 references verified0 citation errors · 0 not checkable

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Authors
Hirsch, G. E., Nazario Viecili, P. R., de Almeida, A. S., Nascimento, S., Porto, F. G., Otero, J., Schmidt, A., da Silva, B., Parisi, M. M., & Klafke, J. Z.
Affiliations
University of Cruz Alta (BR)
Corresponding author
Klafke, Jonatas Zeni
Venue
Current Pharmaceutical Design
Published
2017-04-12
Volume
23
Issue
8
Pages
1228-1246
ISSN
1381-6128 (ISSN-L)
OpenAlex
W2558801373
Cited by
57
References
185
Citations by year
2026: 7 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 12 · 2020: 11 · 2019: 7 · 2018: 5 · 2017: 3
FWCI
5.47
Type
journal article
Language
en
Open access
closed
Locations
  • Current Pharmaceutical Design (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
Keywords
antiplatelet activity, platelet aggregation, medicinal plants, herbal medicine, atherosclerosis, cardiovascular disease, flavonoids, curcumin, catechins, terpenoids, polyphenols, saponins, saffron, garlic, green tea, Hypericum perforatum, ginger, Ginkgo biloba, ginseng, arachidonic acid pathway, serotonin pathway, nitric oxide pathway
MeSH terms
Biological Products, Blood Platelets, Cardiovascular Diseases, Humans, Plants, Medicinal, Platelet Aggregation, Platelet Aggregation Inhibitors

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