Natural Products with Antiplatelet Action
Abstract
BACKGROUND: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation. These mechanisms have been widely studied and discussed because they are inhibited by the use of medicinal plants in complementary and alternative medicine, thus reducing platelet aggregation. RESULTS: Of the main plants discussed in this review, which have antiplatelet activity, some include saffron, garlic, green tea, St. John's wort, ginger, ginkgo biloba, ginseng, and guavirova. These herbal medicines have phytochemical components, which are directly related to the antiplatelet activity of the plant, such as flavonoids, curcumins, catechins, terpenoids, polyphenols, and saponins. While the majority of the medicinal plants mentioned here were native to the Asian continents, some are distributed worldwide, and found to a smaller extent throughout the American continent, European continent, Mediterranean, African continent, and the Middle East. CONCLUSION: This review showed that several plants and/or compounds exhibit anti-platelet activity, and are therefore potential research targets for developing drugs to treat diseases related to aggregation disorders.
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Polyphenols have antiplatelet activity.
“These molecules have also antiplatelet activity [56,57].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [56]
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Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
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“These molecules have also antiplatelet activity [56,57].”
Polyphenols and Oxidative Stress in Atherosclerosis‐Related Ischemic Heart Disease and Stroke
Cheng, Y., Sheen, J.-M., Hu, W.-L., & Hung, Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8526438 · Cited by 259 · see citing works
“platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate (ADP) pathway, serotonin pathway, and NO pathway, and the action of free radicals on molecules is involved in platelet aggregation [135].”
BackgroundAntimicrobial and antioxidant properties of various Greek garlic genotypes
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Molecular Mechanisms of Anticancer Activities of Puerarin
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Sobenin, I. A., Myasoedova, V. A., Iltchuk, M., Zhang, D., & Orekhov, A. N. (2019) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(19)30088-3 · Cited by 70 · see citing works
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BackgroundBotanicals and phytochemicals active on cognitive decline: The clinical evidence
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Li, T., Jin, J., Pu, F., Bai, Y., Chen, Y., Li, Y., & Wang, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1111459 · Cited by 67 · see citing works
“Some studies claimed that curcumin plays an antiplatelet role by inhibiting platelet aggregation (Srivastava et al., 1995; Hirsch et al., 2017), inhibiting cyclooxygenase activity, and blocking calcium channels (Offermanns et al.”
BackgroundResultMetabolome and gut microbiota variation with long-term intake of Panax ginseng extracts on rats
Sun, Y., Chen, S., Wei, R., Xie, X., Wang, C., Fan, S., Zhang, X., Su, J., Liu, J., Jia, W. P., et al. (2018) · Food & Function · doi:10.1039/c8fo00025e · Cited by 64 · see citing works
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Medicinal chemistry inspired by ginger: exploring the chemical space around 6-gingerol
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“Numerous medicinal plants have also demonstrated their bioactivities in reducing platelet aggregation via these mechanisms [13].”
BackgroundDietary Supplements with Antiplatelet Activity: A Solution for Everyone?
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“Various in vitro and in vivo studies indicate that not only antiplatelet drugs, such as aspirin (acetylsalicylic acid), but also certain components of the diet and dietary supplements with antiplatelet activity may reduce blood platelet activation andmay have an important influence on the prophylaxis and treatment of…”
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- Authors
- Hirsch, G. E., Nazario Viecili, P. R., de Almeida, A. S., Nascimento, S., Porto, F. G., Otero, J., Schmidt, A., da Silva, B., Parisi, M. M., & Klafke, J. Z.
- Affiliations
- University of Cruz Alta (BR)
- Corresponding author
- Klafke, Jonatas Zeni
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2017-04-12
- Volume
- 23
- Issue
- 8
- Pages
- 1228-1246
- ISSN
- 1381-6128 (ISSN-L)
- OpenAlex
- W2558801373
- Cited by
- 57
- References
- 185
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 12 · 2020: 11 · 2019: 7 · 2018: 5 · 2017: 3
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Keywords
- antiplatelet activity, platelet aggregation, medicinal plants, herbal medicine, atherosclerosis, cardiovascular disease, flavonoids, curcumin, catechins, terpenoids, polyphenols, saponins, saffron, garlic, green tea, Hypericum perforatum, ginger, Ginkgo biloba, ginseng, arachidonic acid pathway, serotonin pathway, nitric oxide pathway
- MeSH terms
- Biological Products, Blood Platelets, Cardiovascular Diseases, Humans, Plants, Medicinal, Platelet Aggregation, Platelet Aggregation Inhibitors
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