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Cited by 527Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

The DOI matches its Crossref record; 88 of the 91 references it cites were found in a registry or an index.

Polycystic Ovarian Syndrome: Correlation Between Hyperandrogenism, Insulin Resistance and Obesity.

Zeng, Xin, Xie, Yuan-jie, Liu, Ya-ting, Long, Shuang-lian, Mo, Zhong-cheng·2020·Clinica Chimica Acta
DOI 10.1016/j.cca.2019.11.003
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Abstract

Polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine disease characterized by clinical or laboratorial hyperandrogenism, oligo-anovulation and metabolic abnormalities, including insulin resistance, excessive weight or obesity, type II diabetes, dyslipidemia and an increased risk of cardiovascular disease. The most significant clinical manifestation of PCOS is hyperandrogenism. Excess androgen profoundly affects granulosa cell function and follicular development via complex mechanisms that lead to obesity and insulin resistance. Most PCOS patients with hyperandrogenism have steroid secretion defects that result in abnormal folliculogenesis and failed dominant follicle selection. Hyperandrogenism induces obesity, hairy, acne, and androgenetic alopecia. These symptoms can bring great psychological stress to women. Drugs such as combined oral contraceptive pills, metformin, pioglitazone and low-dose spironolactone help improve pregnancy rates by decreasing androgen levels in vivo. Notably, PCOS is heterogeneous, and hyperandrogenism is not the only pathogenic factor. Obesity and insulin resistance aggravate the symptoms of hyperandrogenism, forming a vicious cycle that promotes PCOS development. Although numerous studies have been conducted, the definitive pathogenic mechanisms of PCOS remain uncertain. This review summarizes and discusses previous and recent findings regarding the relationship between hyperandrogenism, insulin resistance, obesity and PCOS.

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Crossref · 10.1016/j.cca.2019.11.003

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  1. Araújo, 2018, The obesogen tributyltin induces abnormal ovarian adipogenesis in adult female rats, Toxicol. Lett., 11, 327

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Metadata

Authors
Zeng, X., Xie, Y.-J., Liu, Y.-T., Long, S.-L., & Mo, Z.-C.
Affiliations
University of South China (CN)
Corresponding author
Long, Shuang-lian
ORCID
Zeng, Xin
Venue
Clinica Chimica Acta
Publisher
Elsevier BV
Published
2020-03
Volume
502
Pages
214-221
ISSN
0009-8981 (ISSN-L)
DOI
10.1016/j.cca.2019.11.003
OpenAlex
W2987017313
Cited by
525
References
91
Citations by year
2026: 57 · 2025: 108 · 2024: 99 · 2023: 112 · 2022: 84 · 2021: 49 · 2020: 16
FWCI
5.27
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinica Chimica Acta (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Sciences Foundation of Hunan Province (2017JJ2233)
  • Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City (2017KJ182)
  • University of South China (2018XJXZ373)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, hyperandrogenism, insulin resistance, obesity, androgenetic alopecia, acne, oligoanovulation, folliculogenesis, dominant follicle selection, metformin, spironolactone, pioglitazone, oral contraceptives, type 2 diabetes, cardiovascular risk
MeSH terms
Pioglitazone, Androgens, Female, Humans, Hypoglycemic Agents, Insulin Resistance, Metformin, Obesity, Polycystic Ovary Syndrome, Spironolactone, Hyperandrogenism

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