Cited by 527Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

The DOI matches its Crossref record; 88 of the 91 references it cites were found in a registry or an index.

Polycystic Ovarian Syndrome: Correlation Between Hyperandrogenism, Insulin Resistance and Obesity.

Zeng, Xin, Xie, Yuan-jie, Liu, Ya-ting, Long, Shuang-lian, Mo, Zhong-cheng·2020·Clinica Chimica Acta

DOI 10.1016/j.cca.2019.11.003

Open this paper in CoChat — free account

Abstract

Polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine disease characterized by clinical or laboratorial hyperandrogenism, oligo-anovulation and metabolic abnormalities, including insulin resistance, excessive weight or obesity, type II diabetes, dyslipidemia and an increased risk of cardiovascular disease. The most significant clinical manifestation of PCOS is hyperandrogenism. Excess androgen profoundly affects granulosa cell function and follicular development via complex mechanisms that lead to obesity and insulin resistance. Most PCOS patients with hyperandrogenism have steroid secretion defects that result in abnormal folliculogenesis and failed dominant follicle selection. Hyperandrogenism induces obesity, hairy, acne, and androgenetic alopecia. These symptoms can bring great psychological stress to women. Drugs such as combined oral contraceptive pills, metformin, pioglitazone and low-dose spironolactone help improve pregnancy rates by decreasing androgen levels in vivo. Notably, PCOS is heterogeneous, and hyperandrogenism is not the only pathogenic factor. Obesity and insulin resistance aggravate the symptoms of hyperandrogenism, forming a vicious cycle that promotes PCOS development. Although numerous studies have been conducted, the definitive pathogenic mechanisms of PCOS remain uncertain. This review summarizes and discusses previous and recent findings regarding the relationship between hyperandrogenism, insulin resistance, obesity and PCOS.

Integrity signals

Registry

Crossref · 10.1016/j.cca.2019.11.003

Cites

88 of 88 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
Recommendations from the international evidence‐based guideline for the assessment and management of polycystic ovary syndrome
Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J., & the International PCOS Network (2018) · Clinical Endocrinology · doi:10.1111/cen.13795 · Cited by 1,823
Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome
Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J., International PCOS Network, Andersen, M., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey256 · Cited by 1,593
Anti-Mullerian Hormone Serum Concentrations in Normoovulatory and Anovulatory Women of Reproductive Age
Laven, J. S. E., Mulders, A. G. M. G. J., Visser, J. A., Themmen, A. P. N., de Jong, F. H., & Fauser, B. C. J. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030932 · Cited by 519
Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling
Corbould, A., Kim, Y.-B., Youngren, J. F., Pender, C., Kahn, B. B., Lee, A., & Dunaif, A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2004 · Cited by 283
11-Oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome
O’Reilly, M. W., Kempegowda, P., Jenkinson, C., Taylor, A. E., Quanson, J. L., Storbeck, K.-H., & Arlt, W. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3285 · Cited by 267
Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial
Jedel, E., Labrie, F., Odén, A., Holm, G., Nilsson, L., Janson, P. O., Lind, A., Ohlsson, C., & Stener‐Victorin, E. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00495.2010 · Cited by 228
Adiponectin Induces Periovulatory Changes in Ovarian Follicular Cells
Ledoux, S., Campos, D. B., Lopes, F. L., Dobias-Goff, M., Palin, M., & Murphy, B. D. (2006) · Endocrinology · doi:10.1210/en.2006-0679 · Cited by 188
Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women
Corbould, A. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07070 · Cited by 184
Differential Gene Expression Profile in Omental Adipose Tissue in Women with Polycystic Ovary Syndrome
Cortón, M., Botella-Carretero, J. I., Benguría, A., Villuendas, G., Zaballos, Á., Millán, J. L. S., Escobar-Morreale, H. F., & Peral, B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1665 · Cited by 174
Increased Oocyte Degeneration and Follicular Atresia during the Estrous Cycle in Anti-Mullerian Hormone Null Mice
Visser, J. A., Durlinger, A. L. L., Peters, I. J. J., van den Heuvel, E. R., Rose, U. M., Kramer, P., de Jong, F. H., & Themmen, A. P. N. (2007) · Endocrinology · doi:10.1210/en.2006-1265 · Cited by 170
Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells
Chabrolle, C., Tosca, L., Ramé, C., Lecomte, P., Royère, D., & Dupont, J. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.008 · Cited by 163
Insulin Augmentation of 17α-Hydroxylase Activity Is Mediated by Phosphatidyl Inositol 3-Kinase But Not Extracellular Signal-Regulated Kinase-1/2 in Human Ovarian Theca Cells
Munir, I., Yen, H.-W., Geller, D. H., Torbati, D., Bierden, R. M., Weitsman, S. R., Agarwal, S. K., & Magoffin, D. A. (2003) · Endocrinology · doi:10.1210/en.2003-0329 · Cited by 163
Polycystic ovary syndrome, adipose tissue and metabolic syndrome
Delitala, A. P., Capobianco, G., Delitala, G., Cherchi, P. L., & Dessole, S. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4429-2 · Cited by 159
Interactive Stimulation by Luteinizing Hormone and Insulin of the Steroidogenic Acute Regulatory (StAR) Protein and 17α-Hydroxylase/17, 20-Lyase (CYP17) Genes in Porcine Theca Cells1
Zhang, G., Garmey, J. C., & Veldhuis, P. P. (2000) · Endocrinology · doi:10.1210/endo.141.8.7595 · Cited by 127
Evaluation of different ranges of LH:FSH ratios in polycystic ovarian syndrome (PCOS) – Clinical based case control study
Malini, N. A., & George, K. R. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.12.007 · Cited by 114
11-oxygenated C19 steroids Do not decline with age in women
Nanba, A. T., Rege, J., Ren, J., Auchus, R. J., Rainey, W. E., & Turcu, A. F. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02527 · Cited by 113
Factors Influencing Follicle-Stimulating Hormone-Responsive Steroidogenesis in Marmoset Granulosa Cells: Effects of Androgens and the Stage of Follicular Maturity*
Harlow, C. R., Shaw, H. J., Hillier, S. G., & Hodges, J. K. (1988) · Endocrinology · doi:10.1210/endo-122-6-2780 · Cited by 112
Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome ( PCOS ): A Randomized Controlled Trial
Arentz, S., Smith, C. A., Abbott, J. A., Fahey, P. P., Cheema, B. S., & Bensoussan, A. (2017) · Phytotherapy Research · doi:10.1002/ptr.5858 · Cited by 103
Follicular hyperandrogenism downregulates aromatase in luteinized granulosa cells in polycystic ovary syndrome women
Yang, F., Ruan, Y. C., Yang, Y.-J., Wang, K., Liang, S.-S., Han, Y.-B., Teng, X.-M., & Yang, J.-Z. (2015) · Reproduction · doi:10.1530/rep-15-0044 · Cited by 98
Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity 1
Ciaraldi, T. P., Morales, A. J., Hickman, M. G., Odom-Ford, R., Olefsky, J. M., & Yen, S. S. C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3961 · Cited by 96
Thecal Cell Sensitivity to Luteinizing Hormone and Insulin in Polycystic Ovarian Syndrome
Cadagan, D., Khan, R., & Amer, S. (2016) · Reproductive Biology · doi:10.1016/j.repbio.2015.12.006 · Cited by 92
Identification of a Functional Polymorphism of the Human Type 5 17β-Hydroxysteroid Dehydrogenase Gene Associated with Polycystic Ovary Syndrome
Qin, K., Ehrmann, D. A., Cox, N. J., Refetoff, S., & Rosenfield, R. L. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2012 · Cited by 84
SHBG expression is correlated with PI3K/AKT pathway activity in a cellular model of human insulin resistance
Feng, C., Jin, Z., Chi, X., Zhang, B., Wang, X., Sun, L., Fan, J., Sun, Q., & Zhang, X. (2018) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1411474 · Cited by 84
Effect of the combined oral contraceptive pill and/or metformin in the management of polycystic ovary syndrome: A systematic review with meta‐analyses
Teede, H., Tassone, E. C., Piltonen, T., Malhotra, J., Mol, B. W., Peña, A., Witchel, S. F., Joham, A., McAllister, V., Romualdi, D., et al. (2019) · Clinical Endocrinology · doi:10.1111/cen.14013 · Cited by 79
Dysregulation of the Anti-Müllerian Hormone System by Steroids in Women With Polycystic Ovary Syndrome
Pierre, A., Taieb, J., Giton, F., Grynberg, M., Touleimat, S., Hachem, H. E., Fanchin, R. R. F., Monniaux, D., Cohen-Tannoudji, J., di Clemente, N., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00308 · Cited by 76
Oral contraceptives versus physical exercise on cardiovascular and metabolic risk factors in women with polycystic ovary syndrome: a randomized controlled trial
Orio, F., Muscogiuri, G., Giallauria, F., Savastano, S., Bottiglieri, P., Tafuri, D., Predotti, P., Colarieti, G., Colao, A., & Palomba, S. (2016) · Clinical Endocrinology · doi:10.1111/cen.13112 · Cited by 75
Dynamics and control of the ERK signaling pathway: Sensitivity, bistability, and oscillations
Arkun, Y., & Yasemi, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195513 · Cited by 75
miR-323-3p regulates the steroidogenesis and cell apoptosis in polycystic ovary syndrome (PCOS) by targeting IGF-1
Wang, T., Liu, Y., Lv, M., Xing, Q., Zhang, Z., He, X., Xu, Y., Wei, Z., & Cao, Y. (2018) · Gene · doi:10.1016/j.gene.2018.10.006 · Cited by 75
Self-citation
Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids
Salilew‐Wondim, D., Wang, Q., Tesfaye, D., Schellander, K., Hoelker, M., Hossain, M. M., & Tsang, B. K. (2015) · Journal of Ovarian Research · doi:10.1186/s13048-015-0151-5 · Cited by 74
Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity
Ciaraldi, T. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.5.1421 · Cited by 72
GnRH secretion is inhibited by adiponectin through activation of AMP-activated protein kinase and extracellular signal-regulated kinase
Cheng, X., Wen, J., Yang, J., Yang, Y., Ning, G., & Li, X.-Y. (2010) · Endocrine · doi:10.1007/s12020-010-9375-8 · Cited by 71
Elevated androgens during puberty in female rhesus monkeys lead to increased neuronal drive to the reproductive axis: a possible component of polycystic ovary syndrome.
McGee, W., Bishop, C., Bahar, A., Pohl, C., Chang, R., Marshall, J., Pau, F., Stouffer, R., & Cameron, J. (2012) · Human Reproduction · doi:10.1093/humrep/der393 · Cited by 71
Study of visceral and subcutaneous abdominal fat thickness and its correlation with cardiometabolic risk factors and hormonal parameters in polycystic ovary syndrome
Choudhury, A., Jena, D., Mangaraj, S., Singh, M., Mohanty, B., & Baliarsinha, A. K. (2018) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_646_17 · Cited by 71
Comparison of ovarian stromal blood flow between fertile women with normal ovaries and infertile women with polycystic ovary syndrome
Ng, E. H. Y., Chan, C. C. W., Yeung, W. S. B., & Ho, P. C. (2005) · Human Reproduction · doi:10.1093/humrep/deh853 · Cited by 67
Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling
Lan, C.-W., Chen, M., Tai, K., Yu, D. C. W., Yang, Y.-C., Jan, P.-S., Yang, Y., Chen, H., & Ho, H. (2015) · Scientific Reports · doi:10.1038/srep14994 · Cited by 67
Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects
Kurzthaler, D., Hadziomerovic-Pekic, D., Wildt, L., & Seeber, B. E. (2014) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-12-98 · Cited by 66
Direct actions of androgens on the survival, growth and secretion of steroids and anti-Mullerian hormone by individual macaque follicles during three-dimensional culture
Rodrigues, J. K., Navarro, P. A., Zelinski, M. B., Stouffer, R. L., & Xu, J. (2015) · Human Reproduction · doi:10.1093/humrep/deu335 · Cited by 66
Insulin and Insulin-Like Growth Factor Stimulation of Vascular Endothelial Growth Factor Production by Luteinized Granulosa Cells: Comparison between Polycystic Ovarian Syndrome (PCOS) and Non-PCOS Women
Stanek, M. B., Borman, S. M., Molskness, T. A., Larson, J. M., Stouffer, R. L., & Patton, P. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2846 · Cited by 65
The obesogen tributyltin induces abnormal ovarian adipogenesis in adult female rats
de Araújo, J. F. P., Podratz, P. L., Sena, G. C., Merlo, E., Freitas-Lima, L. C., Ayub, J. G. M., Pereira, A. F. Z., Santos-Silva, A. P., Miranda-Alves, L., Silva, I. V., et al. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.06.1068 · Cited by 65
Regulation of androgen receptor signaling by ubiquitination during folliculogenesis and its possible dysregulation in polycystic ovarian syndrome
Lim, J. J., Lima, P., Salehi, R., Lee, D. R., & Tsang, B. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-09880-0 · Cited by 64
Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway
Qu, F., Wang, F., Lu, X.-P., Dong, M. Y., Sheng, J., Lv, P. P., Ding, G., Shi, B., Zhang, D., & Huang, H. (2010) · Human Reproduction · doi:10.1093/humrep/deq078 · Cited by 64
Adiponectin synthesis and secretion by subcutaneous adipose tissue is impaired during obesity by endoplasmic reticulum stress
Torre-Villalvazo, I., Bunt, A. E., Alemán, G., Marquez-Mota, C. C., Díaz‐Villaseñor, A., Noriega, L. G., Estrada, I., Figueroa‐Juárez, E., Tovar‐Palacio, C., Rodríguez-López, L. A., et al. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26794 · Cited by 62
Dehydroepiandrosterone-induced activation of mTORC1 and inhibition of autophagy contribute to skeletal muscle insulin resistance in a mouse model of polycystic ovary syndrome
Song, X., Shen, Q., Fan, L., Yu, Q., Jia, X., Sun, Y., Bai, W., & Kang, J. (2018) · Oncotarget · doi:10.18632/oncotarget.24190 · Cited by 61
The orphan nuclear receptor NR4A1 regulates transcription of key steroidogenic enzymes in ovarian theca cells
Li, M., Xue, K., Jing, L., Diao, F., Cui, Y., & Liu, J. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.014 · Cited by 61
Vitamin D3 regulates steroidogenesis in granulosa cells through AMP‐activated protein kinase (AMPK) activation in a mouse model of polycystic ovary syndrome
Bakhshalizadeh, S., Amidi, F., Shirazi, R., & Nashtaei, M. S. (2018) · Cell Biochemistry and Function · doi:10.1002/cbf.3330 · Cited by 60
MicroRNA-27a-3p affects estradiol and androgen imbalance by targeting Creb1 in the granulosa cells in mouse polycytic ovary syndrome model
Wang, M., Liu, M., Sun, J., Jia, L., Ma, S., Gao, J., Xu, Y., Zhang, H., Tsang, S. Y., & Li, X. (2017) · Reproductive Biology · doi:10.1016/j.repbio.2017.09.005 · Cited by 60
Molecular characterization of insulin resistance and glycolytic metabolism in the rat uterus
Zhang, Y., Sun, X., Sun, X., Meng, F., Hu, M., Li, X., Li, W., Wu, X., Brännström, M., Shao, R., et al. (2016) · Scientific Reports · doi:10.1038/srep30679 · Cited by 59
Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice
Wang, H., Cheng, Q., Li, X., Hu, F., Han, L., Zhang, H., Li, L., Ge, J., Ying, X., Guo, X., et al. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000620 · Cited by 56
Extracellular signal-regulated kinases (ERK) 1, 2 are required for luteinizing hormone (LH)-induced steroidogenesis in primary Leydig cells and control steroidogenic acute regulatory (StAR) expression
Martinat, N., Crépieux, P., Reiter, É., & Guillou, F. (2005) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2005007 · Cited by 54
Inflammatory markers in human follicular fluid correlate with lipid levels and Body Mass Index
Gonzalez, M. B., Lane, M., Knight, E., & Robker, R. L. (2018) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2018.08.005 · Cited by 53
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1
Gonzalez, E. R., & Guengerich, F. P. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.794917 · Cited by 52
Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons
Hu, Q., Jin, J., Zhou, H., Yu, D., Qian, W., Zhong, Y., Zhang, J., Tang, C., Liu, P., Zhou, Y., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.135 · Cited by 52
A Hyperandrogenic Environment Causes Intrinsic Defects That Are Detrimental to Follicular Dynamics in a PCOS Mouse Model
Bertoldo, M. J., Caldwell, A. S. L., Riepsamen, A. H., Lin, D., Gonzalez, M. B., Robker, R. L., Ledger, W. J., Gilchrist, R. B., Handelsman, D. J., & Walters, K. A. (2019) · Endocrinology · doi:10.1210/en.2018-00966 · Cited by 52
Leptin-Induced CART (Cocaine- and Amphetamine-Regulated Transcript) Is a Novel Intraovarian Mediator of Obesity-Related Infertility in Females
Ma, X., Hayes, E. T., Prizant, H., Srivastava, R. K., Hammes, S. R., & Sen, A. (2016) · Endocrinology · doi:10.1210/en.2015-1750 · Cited by 51
Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production
Peng, H., Im, S., Pearl, N. M., Turcu, A. F., Rege, J., Waskell, L. A., & Auchus, R. J. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00532 · Cited by 51
In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone
Mazza, A., Fruci, B., Guzzi, P. H., D'Orrico, B., Malaguarnera, R., Veltri, P., Fava, A., & Belfiore, A. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2013.04.016 · Cited by 50
Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS
Li, H., Chen, Y., Yan, L., & Qiao, J. (2012) · Endocrine · doi:10.1007/s12020-012-9739-3 · Cited by 48
Dysregulation of Ovarian Follicular Development in Female Rat: LH Decreases FSH Sensitivity During Preantral-Early Antral Transition
Orisaka, M., Hattori, K., Fukuda, S., Mizutani, T., Miyamoto, K., Sato, T., Tsang, B. K., Kotsuji, F., & Yoshida, Y. (2013) · Endocrinology · doi:10.1210/en.2012-2173 · Cited by 48
Metformin InhibitsStARExpression in Human Endometriotic Stromal Cells via AMPK-Mediated Disruption of CREB-CRTC2 Complex Formation
Xu, J., Zeng, C., Zhou, Y., Peng, C., Zhou, Y.-F., & Xue, Q. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1593 · Cited by 44
Ring Finger Protein 6 Mediates Androgen-Induced Granulosa Cell Proliferation and Follicle Growth via Modulation of Androgen Receptor Signaling
Lim, J. J., Han, C. Y., Lee, D. R., & Tsang, B. K. (2017) · Endocrinology · doi:10.1210/en.2016-1866 · Cited by 42
Cryptotanshinone Reverses Reproductive and Metabolic Disturbances in PCOS Model Rats via Regulating the Expression of CYP17 and AR
Yu, J., Zhai, D., Li, H., Zhang, D., Bai, L., Cai, Z., & Yu, C. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/670743 · Cited by 41
Metformin and pioglitazone combination therapy ameliorate polycystic ovary syndrome through AMPK/PI3K/JNK pathway
Wu, Y., Li, P., Zhang, D., & Sun, Y. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5650 · Cited by 41
Luteinizing Hormone Facilitates Antral Follicular Maturation and Survival via Thecal Paracrine Signaling in Cattle
Hattori, K., Orisaka, M., Fukuda, S., Tajima, K., Yamazaki, Y., Mizutani, T., & Yoshida, Y. (2018) · Endocrinology · doi:10.1210/en.2018-00123 · Cited by 39
SIRT7 functions in redox homeostasis and cytoskeletal organization during oocyte maturation
Gao, M., Li, X., He, Y., Han, L., Qiu, D., Li, L., Liu, H., Liu, J., & Gu, L. (2018) · The FASEB Journal · doi:10.1096/fj.201800078rr · Cited by 39
Follicular hyperandrogenism and insulin resistance in polycystic ovary syndrome patients with normal circulating testosterone levels
Li, A., Lu, Z., Jiajia, J., Yang, N., Ying, L., Lingbo, C., Yugui, C., Feiyang, D., Han, X., Jiayin, L., et al. (2018) · Journal of Biomedical Research · doi:10.7555/jbr.32.20170136 · Cited by 38
Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo
Pereira, S., Park, E., Moore, J., Faubert, B., Breen, D. M., Oprescu, A. I., Nahle, A., Kwan, D., Giacca, A., & Tsiani, E. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0075 · Cited by 34
The Involvement of Granulosa Cells in the Regulation by Gonadotropins of Cyp17a1 in Theca Cells
Kakuta, H., Iguchi, T., & Sato, T. (2018) · In Vivo · doi:10.21873/invivo.11391 · Cited by 34
Effect of Body Weight on Metabolic Hormones and Fatty Acid Metabolism in Follicular Fluid of Women Undergoing In Vitro Fertilization: A Pilot Study
Nemer, L. B., Shi, H., Carr, B. R., Word, R. A., & Bükülmez, O. (2018) · Reproductive Sciences · doi:10.1177/1933719118776787 · Cited by 33
Hyperandrogenism Enhances Muscle Strength After Progressive Resistance Training, Independent of Body Composition, in Women With Polycystic Ovary Syndrome
Kogure, G. S., Silva, R. C., Furtado, C. L. M., Ribeiro, V. B., Pedroso, D. C. C., de Melo, A. S., Ferriani, R. A., & dos Reis, R. M. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002714 · Cited by 33
Expression of genes controlling steroid metabolism and action in granulosa-lutein cells of women with polycystic ovaries
Lerner, A., Owens, L. A., Coates, M., Simpson, C., Poole, G., Velupillai, J., Liyanage, M., Christopoulos, G., Lavery, S. A., Hardy, K., et al. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.02.015 · Cited by 33
Effect of acute physiological free fatty acid elevation in the context of hyperinsulinemia on fiber type-specific IMCL accumulation
Chow, L. S., Mashek, D. G., Wang, Q., Shepherd, S. O., Goodpaster, B. H., & Dubé, J. J. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00209.2017 · Cited by 30
High-molecular-weight adiponectin is inversely associated with sympathetic activity in polycystic ovary syndrome
Shorakae, S., Abell, S. K., Hiam, D., Lambert, É., Eikelis, N., Jona, E., Sari, C. I., Stepto, N. K., Lambert, G. W., de Courten, B. V., et al. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.11.020 · Cited by 30
Causes, patterns and severity of androgen excess in 487 consecutively recruited pre- and post-pubertal children
Idkowiak, J., Elhassan, Y., Mannion, P., Smith, K. A., Webster, R., Saraff, V., Barrett, T. G., Shaw, N. J., Krone, N. P., Dias, R. P., et al. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0854 · Cited by 28
Hyperandrogenism stimulates inflammation and promote apoptosis of cumulus cells
Xu, F., Liu, R., & Cao, X. (2017) · Cellular and Molecular Biology · doi:10.14715/cmb/2017.63.10.10 · Cited by 28
Body Fat Mass Is Associated With Ratio of Steroid Metabolites Reflecting 17,20-Lyase Activity in Prepubertal Girls
Kim, S.-H., Moon, J.-Y., Sasano, H., Choi, M. H., & Park, M.-J. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2515 · Cited by 27
Relationship Between Steroid Hormones and Metabolic Profile in Women With Polycystic Ovary Syndrome
Lazúrová, I., Lazúrová, Z., Figurová, J., Ujhazi, S., Dravecká, I., Mašlanková, J., & Mareková, M. (2019) · Physiological Research · doi:10.33549/physiolres.934062 · Cited by 26
Body fat affects mouse reproduction, ovarian hormone release, and response to follicular stimulating hormone
Sirotkin, A. V., Fabián, D., Babeľová, J., Vlčková, R., Alwasel, S. H., & Harrath, A. H. (2017) · Reproductive Biology · doi:10.1016/j.repbio.2017.12.002 · Cited by 23
The role of androgens in follicular development in the ovary. I. A quantitative analysis of oocyte ovulation
Ware, V. C. (1982) · Journal of Experimental Zoology · doi:10.1002/jez.1402220207 · Cited by 22
Enhanced Inflammation without Impairment of Insulin Signaling in the Visceral Adipose Tissue of 5α-Dihydrotestosterone-Induced Animal Model of Polycystic Ovary Syndrome
Milutinović, D. V., Nikolič, M., Veličković, N. A., Djordjevic, A. D., Bursać, B. N., Brkljačić, J. M., Teofilović, A., Antić, I. B., Macut, J. B., Shirif, A. Z., et al. (2017) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-104531 · Cited by 21
Impact of Central Obesity on Women with Polycystic Ovary Syndrome Undergoing In Vitro Fertilization
Li, Y., Lin, H., Pan, P., Yang, D., & Zhang, Q. (2018) · BioResearch open access · doi:10.1089/biores.2017.0040 · Cited by 21
3βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging
Nakamura, Y., Fujishima, F., Hui, X.-G., Felizola, S. J. A., Shibahara, Y., Akahira, J., McNamara, K. M., Rainey, W. E., & Sasano, H. (2014) · Endocrine Research · doi:10.3109/07435800.2014.895377 · Cited by 20
Role of A-kinase anchoring protein 95 in the regulation of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) in human ovarian granulosa cells
Gu, Y., Xu, W., Zhuang, B., & Fu, W. (2018) · Reproduction Fertility and Development · doi:10.1071/rd17313 · Cited by 19
Influence of body mass index and polycystic ovarian syndrome on ICSI/IVF treatment outcomes: A study conducted in Pakistani women
Rehman, R., Mehmood, M., Ali, R., Shaharyar, S., & Alam, F. (2018) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.29252/ijrm.16.8.529 · Cited by 17
Androgen responses to adrenocorticotropic hormone infusion among individual women with polycystic ovary syndrome
Maas, K. H., Chuan, S. S., Harrison, E., Cook‐Andersen, H., Dulęba, A. J., & Chang, R. J. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.06.039 · Cited by 16
The effect of oral contraception on cardiometabolic risk factors in women with elevated androgen levels
Krysiak, R. G., Gilowska, M., & Okopień, B. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.09.013 · Cited by 12
Interpretation of androgen and anti-Mullerian hormone profiles in a Hispanic cohort of 5- to 8-year-old girls with premature adrenarche
Brar, P. C., Dingle, E., Ovadia, D., Pivo, S., Prasad, V., & DAVID, R. R. (2018) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2018.23.4.210 · Cited by 5
[Expression of aquaporin 9 in granulosa cells of patients with polycystic ovary syndrome in IVF-cycles].
Lu, X.-E., Qian, Y., & Huang, H.-F. (2007) · PubMed · doi:10.3785/j.issn.1008-9292.2007.05.007 · Cited by 3

Flagged first, then by citations

3 of the 91 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Araújo, 2018, The obesogen tributyltin induces abnormal ovarian adipogenesis in adult female rats, Toxicol. Lett., 11, 327

Sorted by citations

GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects
Zhao, X., Wang, M., Wen, Z., Lu, Z., Cui, L., Fu, C., Xue, H., Liu, Y., & Zhang, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.721135 · Cited by 463
Self-citation
Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing
Sadeghi, H. M., Adeli, I., Calina, D., Docea, A. O., Mousavi, T., Daniali, M., Nikfar, S., Tsatsakis, A., & Abdollahi, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020583 · Cited by 445
Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment
Zhao, H., Zhang, J., Cheng, X., Nie, X., & He, B. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-022-01091-0 · Cited by 408
Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: A review
He, F.-F., & Li, Y.-M. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00670-3 · Cited by 289
The role of androgen and its related signals in PCOS
Ye, W., Xie, T., Song, Y., & Zhou, L. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16205 · Cited by 208

See all 527

Authors: Zeng, X., Xie, Y.-J., Liu, Y.-T., Long, S.-L., & Mo, Z.-C.
Affiliations: University of South China (CN)
Corresponding author: Long, Shuang-lian
ORCID: Zeng, Xin
Venue: Clinica Chimica Acta
Publisher: Elsevier BV
Published: 2020-03
Volume: 502
Pages: 214-221
ISSN: 0009-8981 (ISSN-L)
DOI: 10.1016/j.cca.2019.11.003
OpenAlex: W2987017313
Cited by: 525
References: 91
Citations by year: 2026: 57 · 2025: 108 · 2024: 99 · 2023: 112 · 2022: 84 · 2021: 49 · 2020: 16
FWCI: 5.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinica Chimica Acta (publishedVersion)
PubMed (publishedVersion)
Funders: Natural Sciences Foundation of Hunan Province (2017JJ2233)
Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City (2017KJ182)
University of South China (2018XJXZ373)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: polycystic ovary syndrome, hyperandrogenism, insulin resistance, obesity, androgenetic alopecia, acne, oligoanovulation, folliculogenesis, dominant follicle selection, metformin, spironolactone, pioglitazone, oral contraceptives, type 2 diabetes, cardiovascular risk
MeSH terms: Pioglitazone, Androgens, Female, Humans, Hypoglycemic Agents, Insulin Resistance, Metformin, Obesity, Polycystic Ovary Syndrome, Spironolactone, Hyperandrogenism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Polycystic Ovarian Syndrome: Correlation Between Hyperandrogenism, Insulin Resistance and Obesity.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks