The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
TRPM3 and miR-204 Establish a Regulatory Circuit that Controls Oncogenic Autophagy in Clear Cell Renal Cell Carcinoma
Open accessAbstract
Summary Autophagy promotes tumor growth by generating nutrients from the degradation of intracellular structures. Here we establish, using shRNAs, a dominant negative mutant, and a pharmacologic inhibitor, mefenamic acid (MFA), that the Transient Receptor Potential Melastatin 3 (TRPM3) channel promotes growth of clear cell renal cell carcinoma (ccRCC) and stimulates MAP1LC3A (LC3A) and MAP1LC3B (LC3B) autophagy. Increased expression of TRPM3 in RCC leads to Ca2+ influx, activation of CAMKK2, AMPK, and ULK1, and phagophore formation. In addition, TRPM3 Ca2+ and Zn2+ fluxes inhibit miR-214 which directly targets LC3A and LC3B. The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 through miR-204 directly and indirectly through another miR-204 target, Caveolin 1 (CAV1).
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Cites
Comprehensive molecular characterization of clear cell renal cell carcinoma
The Cancer Genome Atlas Research Network (2013) · Nature · doi:10.1038/nature12222 · Cited by 3,485
The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
Egan, D., Kim, J., Shaw, R. J., & Guan, K.-L. (2011) · Autophagy · doi:10.4161/auto.7.6.15123 · Cited by 627
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells
Wagner, T. F. J., Loch, S., Lambert, S., Straub, I., Mannebach, S., Mathar, I., Düfer, M., Lis, A., Flockerzi, V., Philipp, S. E., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1801 · Cited by 392
Cited by
Autophagy in malignant transformation and cancer progression
Galluzzi, L., Pietrocola, F., Bravo‐San Pedro, J. M., Amaravadi, R. K., Baehrecke, E. H., Cecconi, F., Codogno, P., Debnath, J., Gewirtz, D. A., Karantza, V., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490784 · Cited by 1,182
Calcium and mitochondria in the regulation of cell death
Orrenius, S., Gogvadze, V., & Zhivotovsky, B. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.137 · Cited by 526
Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?
Prevarskaya, N., Skryma, R., & Shuba, Y. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2016 · Cited by 484
Caveolin-1 in the regulation of cell metabolism: a cancer perspective
Nwosu, Z. C., Ebert, M. P., Dooley, S., & Meyer, C. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0558-7 · Cited by 256
Marchi, S., Giorgi, C., Galluzzi, L., & Pinton, P. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.017 · Cited by 235
Metadata
- Authors
- Hall, D. P., Cost, N. G., Hegde, S., Kellner, E., Mikhaylova, O., Stratton, Y., Ehmer, B., Abplanalp, W. A., Pandey, R., Biesiada, J., Harteneck, C., Plas, D. R., Meller, J., & Czyzyk-Krzeska, M. F.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 26
- Issue
- 5
- Pages
- 738-753
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2009387137
- Cited by
- 187
- References
- 3
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Hall, D. P., Cost, N. G., Hegde, S., Kellner, E., Mikhaylova, O., Stratton, Y., Ehmer, B., Abplanalp, W. A., Pandey, R., Biesiada, J., Harteneck, C., Plas, D. R., Meller, J., & Czyzyk-Krzeska, M. F. (2014). TRPM3 and miR-204 Establish a Regulatory Circuit that Controls Oncogenic Autophagy in Clear Cell Renal Cell Carcinoma. Cancer Cell. https://doi.org/10.1016/j.ccell.2014.09.015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
