The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors
Open accessAbstract
Summary The evolutionary history of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and sensitive to the microenvironment, prompting the question whether epigenetic information can similarly be used to discover tumor phylogeny. We examined the spatial and temporal dynamics of DNA methylation in a cohort of low-grade gliomas and their patient-matched recurrences. Genes transcriptionally upregulated through promoter hypomethylation during malignant progression to high-grade glioblastoma were enriched in cell cycle function, evolving in parallel with genetic alterations that deregulate the G1/S cell cycle checkpoint. Moreover, phyloepigenetic relationships robustly recapitulated phylogenetic patterns inferred from somatic mutations. These findings highlight widespread co-dependency of genetic and epigenetic events throughout brain tumor evolution.
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Cited by
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Metadata
- Authors
- Mazor, T., Pankov, A., Johnson, B. E., Hong, C., Hamilton, E. G., Bell, R. J. A., Smirnov, I. V., Reis, G. F., Phillips, J. J., Barnes, M. J., Idbaih, A., Alentorn, A., Kloezeman, J. J., Lamfers, M. L. M., Bollen, A. W., Taylor, B. S., Molinaro, A. M., Olshen, A. B., Chang, S. M., Song, J. S., & Costello, J. F.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 28
- Issue
- 3
- Pages
- 307-317
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1903281529
- Cited by
- 258
- References
- 58
- FWCI
- 15.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mazor, T., Pankov, A., Johnson, B. E., Hong, C., Hamilton, E. G., Bell, R. J. A., Smirnov, I. V., Reis, G. F., Phillips, J. J., Barnes, M. J., Idbaih, A., Alentorn, A., Kloezeman, J. J., Lamfers, M. L. M., Bollen, A. W., Taylor, B. S., Molinaro, A. M., Olshen, A. B., Chang, S. M., . . . Costello, J. F. (2015). DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors. Cancer Cell. https://doi.org/10.1016/j.ccell.2015.07.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
