The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma
Open accessAbstract
Summary Dysregulated metabolism is a hallmark of cancer, manifested through alterations in metabolites. We performed metabolomic profiling on 138 matched clear cell renal cell carcinoma (ccRCC)/normal tissue pairs and found that ccRCC is characterized by broad shifts in central carbon metabolism, one-carbon metabolism and anti-oxidant response. Tumor progression and metastasis were associated with metabolite increases in glutathione and cysteine/methionine metabolism pathways. We develop an analytic pipeline and visualization tool (“metabolograms”) to bridge the gap between TCGA transcriptomic profiling and our metabolomic data, which enables us to assemble an integrated pathway-level metabolic atlas and to demonstrate discordance between transcriptome and metabolome. Lastly, expression profiling was performed on a high-glutathione cluster, which correspond to a poor-survival subgroup in the ccRCC TCGA cohort.
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Cites
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Cited by
Charoentong, P., Finotello, F., Angelova, M., Mayer, C., Efremova, M., Rieder, D., Hackl, H., & Trajanoski, Z. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.019 · Cited by 5,041
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Self-citationUnderstanding the Intersections between Metabolism and Cancer Biology
Vander Heiden, M. G., & DeBerardinis, R. J. (2017) · Cell · doi:10.1016/j.cell.2016.12.039 · Cited by 2,293
Identification of bioactive metabolites using activity metabolomics
Rinschen, M. M., Ivanisevic, J., Giera, M., & Siuzdak, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0108-4 · Cited by 1,008
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Clark, D. J., Dhanasekaran, S. M., Petralia, F., Pan, J., Song, X., Hu, Y., da Veiga Leprevost, F., Reva, B., Lih, T.-S. M., Chang, H.-Y., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.007 · Cited by 730
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Metadata
- Authors
- Hakimi, A. A., Reznik, E., Lee, C.-H., Creighton, C. J., Brannon, A. R., Luna, A., Aksoy, B. A., Liu, E. M., Shen, R., Lee, W., Chen, Y., Stirdivant, S. M., Russo, P., Chen, Y.-B., Tickoo, S. K., Reuter, V. E., Cheng, E. H., Sander, C., & Hsieh, J. J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 29
- Issue
- 1
- Pages
- 104-116
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2234445408
- Cited by
- 798
- References
- 20
- FWCI
- 22.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hakimi, A. A., Reznik, E., Lee, C.-H., Creighton, C. J., Brannon, A. R., Luna, A., Aksoy, B. A., Liu, E. M., Shen, R., Lee, W., Chen, Y., Stirdivant, S. M., Russo, P., Chen, Y.-B., Tickoo, S. K., Reuter, V. E., Cheng, E. H., Sander, C., & Hsieh, J. J. (2016). An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma. Cancer Cell. https://doi.org/10.1016/j.ccell.2015.12.004
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