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Targeting netrin‐3 in small cell lung cancer and neuroblastoma

Jiang, S., Richaud, M., Vieugué, P., Rama, N., Delcros, J., Siouda, M., Sanada, M., Redavid, A. R., Ducarouge, B., Hervieu, M., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202012878 · Cited by 33 · see citing works

Netrin as a Novel Biomarker and Its Therapeutic Implications in Diabetes Mellitus and Diabetes-Associated Complications

Yimer, E. M., Zewdie, K. A., & Hishe, H. Z. (2018) · Journal of Diabetes Research · doi:10.1155/2018/8250521 · Cited by 31 · see citing works

Kremen1-induced cell death is regulated by homo- and heterodimerization

Sumia, I., Pierani, A., & Causeret, F. (2019) · Cell Death Discovery · doi:10.1038/s41420-019-0175-5 · Cited by 28 · see citing works

Netrin-1 in Post-stroke Neuroprotection: Beyond Axon Guidance Cue

Liao, S., Yu, J., & Luo, Y. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220302150723 · Cited by 26 · see citing works

Netrin-1 promotes cell neural invasion in gastric cancer via its receptor neogenin

Yin, K., Wang, L., Xia, Y., Dang, S.-C., Zhang, X., He, Z., Xu, J., Shang, M., & Xu, Z. (2019) · Journal of Cancer · doi:10.7150/jca.30230 · Cited by 25 · see citing works

Glycosylation in Axonal Guidance

Mutalik, S. P., & Gupton, S. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105143 · Cited by 25 · see citing works

UNC5 dependence receptor family in human cancer: A controllable double-edged sword

Zhu, Y., Li, Y., & Nakagawara, A. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.034 · Cited by 25 · see citing works

From netrin‐1‐targeted SPECT/CT to internal radiotherapy for management of advanced solid tumors

Kryza, D., Wischhusen, J. C., Richaud, M., Hervieu, M., Sidi‐Boumedine, J., Delcros, J., Besse, S., Baudier, T., Laval, P., Breusa, S., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216732 · Cited by 23 · see citing works

Suppression of Netrin-1 attenuates angiotension II-induced cardiac remodeling through the PKC/MAPK signaling pathway

Wu, G., Wang, Z., Shan, P., Huang, S., Lin, S., Huang, W., & Huang, Z. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110495 · Cited by 23 · see citing works

Δ40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity

Sun, Y., Manceau, A., Frydman, L., Cappuccio, L., Neves, D., Basso, V., Wang, H., Fombonne, J., Maisse, C., Mehlen, P., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2103319118 · Cited by 22 · see citing works

Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance

Mentxaka, A., Gómez‐Ambrosi, J., Ramírez, B., Rodrı́guez, A., Becerril, S., Neira, G., Valentí, V., Moncada, R., Silva, C., Unamuno, X., et al. (2022) · Nutrients · doi:10.3390/nu14204372 · Cited by 21 · see citing works

The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction

Xu, S., Liu, Y., Li, X., Liu, Y., Meijers, R., Zhang, Y., & Wang, J. (2018) · Cell Discovery · doi:10.1038/s41421-017-0008-8 · Cited by 20 · see citing works

Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer

Dong, D., Zhang, R., Shao, J., Zhang, A., Wang, Y., Zhou, Y., & Li, Y. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01211-5 · Cited by 18 · see citing works

The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation

Meier, M., Gupta, M., Akgül, Ş., McDougall, M., Imhof, T., Nikodemus, D., Reuten, R., Moya, A., To, V., Ferens, F. G., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36692-w · Cited by 18 · see citing works

Immune Environment and Immunotherapy in Endometrial Carcinoma and Cervical Tumors

Lainé, A., López, A. M. G., Hasan, U. A., Ohkuma, R., & Ray-Coquard, I. L. (2023) · Cancers · doi:10.3390/cancers15072042 · Cited by 18 · see citing works

Hepatic inflammation elicits production of proinflammatory netrin‐1 through exclusive activation of translation

Barnault, R., Verzeroli, C., Fournier, C., Michelet, M., Redavid, A. R., Chicherova, I., Plissonnier, M., Adrait, A., Khomich, O. A., Chapus, F., et al. (2022) · Hepatology · doi:10.1002/hep.32446 · Cited by 18 · see citing works

Biophysical characterisation of human LincRNA-p21 sense and antisense Alu inverted repeats

D’Souza, M. H., Mrozowich, T., Badmalia, M. D., Geeraert, M., Frederickson, A., Henrickson, A., Demeler, B., Wolfinger, M. T., & Patel, T. R. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac414 · Cited by 16 · see citing works

Chimeric protein identification of dystrophic, Pierson and other laminin polymerization residues

McKee, K. K., Aleksandrova, M., & Yurchenco, P. D. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.012 · Cited by 16 · see citing works

Insights from the neural guidance factor Netrin-1 into neurodegeneration and other diseases

Cai, M., Zheng, Q., Chen, Y., Liu, S., Zhu, H., & Bai, B. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1379726 · Cited by 13 · see citing works

Molecular characterization of Netrin-1 and APP receptor binding: New leads to block the progression of senile plaques in Alzheimer's disease

Borel, F., Marzocca, F., Delcros, J., Rama, N., Mehlen, P., & Ferrer, J.-L. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.056 · Cited by 13 · see citing works

Neural function of Netrin-1 in precancerous lesions of the pancreas

Haidar, H., Bellon, A., Sleiman, K., Hocine, M., Rama, N., Gadot, N., Carpizo, D. R., Mehlen, P., & Mann, F. (2025) · Nature Communications · doi:10.1038/s41467-025-62299-4 · Cited by 12 · see citing works

Distinct expression of select and transcriptome-wide isolated 3’UTRs suggests critical roles in development and transition states

Ji, S., Yang, Z., Gozali, L., Kenney, T., Kocabas, A. M., Park, C. J., & Hynes, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250669 · Cited by 12 · see citing works

Polyomavirus Small T Antigen Induces Apoptosis in Mammalian Cells through the UNC5B Pathway in a PP2A-Dependent Manner

Bhat, S. A., Sarwar, Z., Gillani, S. Q., Nisa, M. U., Reshi, I., Nabi, N., Xie, S., Fazili, K. M., Roberts, T. M., & Andrabi, S. (2020) · Journal of Virology · doi:10.1128/jvi.02187-19 · Cited by 11 · see citing works

Netrin-1: Key insights in neural development and disorders

Mustafa, A. N., Mahdi, M. S., Ballal, S., Chahar, M., Verma, R. K., Al-Nuaimi, A. M. A., Kumar, M. R., Al-Hussein, R. K. A., Adil, M., & Jawad, M. J. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102678 · Cited by 10 · see citing works

Netrin-1 Promotes Pancreatic Tumorigenesis and Innervation through NEO1

Ochiai, Y., Kobayashi, H., Sunagawa, M., Baba, T., Malagola, E., Wu, F., Tanaka, T., Hata, M., Arai, J., Jiang, Z., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-2243 · Cited by 10 · see citing works

Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

Perampalam, P., MacDonald, J. I., Zakirova, K., Passos, D. T., Wasif, S., Ramos-Valdes, Y., Hervieu, M., Mehlen, P., Rottapel, R. K., Gibert, B., et al. (2023) · eLife · doi:10.7554/elife.91766 · Cited by 10 · see citing works

Crystallographic analysis of the laminin β2 short arm reveals how the LF domain is inserted into a regular array of LE domains

Pulido, D., Briggs, D. C., Hua, J., & Hohenester, E. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.06.006 · Cited by 10 · see citing works

Netrin-1 promotes epithelium repair in corneal injury

Han, Y. (2020) · International Journal of Ophthalmology · doi:10.18240/ijo.2020.02.02 · Cited by 10 · see citing works

Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer

Roth, G. S., Artru, P., Bouché, O., Williet, N., Ghelfi, J., Turpin, A., Lièvre, A., Blanc, J., Evrard, C., Bachet, J., et al. (2026) · Nature · doi:10.1038/s41586-026-10436-4 · Cited by 9 · see citing works

Anti-Netrin-1 decorated nanoparticles combined with chemotherapy for the treatment of triple-negative breast cancer

Breusa, S., Thomas, E., Baldinotti, N., Zilio, S., Delcros, J., Palomino, D. M. H., Qi, W., Guérin, H., Gibert, B., Mehlen, P., et al. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.213881 · Cited by 9 · see citing works

Solution Structure of C. elegans UNC-6: A Nematode Paralogue of the Axon Guidance Protein Netrin-1

Krahn, N., Meier, M., Reuten, R., Koch, M., Stetefeld, J., & Patel, T. R. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2019.04.033 · Cited by 9 · see citing works

Homogenous overexpression of the extracellular matrix protein Netrin-1 in a hollow fiber bioreactor

Moya, A., Gupta, M., Heide, F., Krahn, N., Legare, S., Nikodemus, D., Imhof, T., Meier, M., Koch, M., & Stetefeld, J. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11438-0 · Cited by 9 · see citing works

Increased Expression Levels of Netrin-1 in Visceral Adipose Tissue during Obesity Favour Colon Cancer Cell Migration

Mentxaka, A., Gómez‐Ambrosi, J., Neira, G., Ramírez, B., Becerril, S., Rodrı́guez, A., Valentí, V., Moncada, R., Baixauli, J., Burrell, M. A., et al. (2023) · Cancers · doi:10.3390/cancers15041038 · Cited by 8 · see citing works

Structural insights into the formation of repulsive netrin guidance complexes

Priest, J. M., Nichols, E. L., Smock, R. G., Hopkins, J. B., Mendoza, J. L., Meijers, R., Shen, K., & Özkan, E. (2024) · Science Advances · doi:10.1126/sciadv.adj8083 · Cited by 8 · see citing works

The effect of aspirin on circulating netrin-1 levels in humans is dependent on the inflammatory status of the vascular endothelium

Layne, K. A., Goodman, T., Ferro, A., & Passacquale, G. (2017) · Oncotarget · doi:10.18632/oncotarget.21240 · Cited by 8 · see citing works

Sonic hedgehog medulloblastomas are dependent on Netrin-1 for survival

Talbot, J., Fombonne, J., Torrejon-Diaz, J., Babcock, B. R., McSwain, L., Rama, N., Severini, L. L., Bonerandi, E., Marsaud, V., Bernardi, F., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59612-6 · Cited by 7 · see citing works

The Role of Macrophage-Derived Netrin-1 in Inflammatory Diseases

Wu, Y., Liu, Z., Xu, P., Yin, K., & Wang, S. (2025) · Biomolecules · doi:10.3390/biom15070921 · Cited by 7 · see citing works

Review of Canadian Light Source facilities for biological applications

Grochulski, P., Fodje, M. N., Labiuk, S., Wysokiński, T. W., Belev, G. S., Korbas, M., & Rosendahl, S. M. (2017) · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms · doi:10.1016/j.nimb.2017.01.065 · Cited by 7 · see citing works

Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes

Barnault, R., Lahlali, T., Plissonnier, M., Romero‐López, C., Laverdure, N., Ducarouge, B., Rivoire, M. L., Mehlen, P., Zoulim, F., & Parent, R. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.129 · Cited by 7 · see citing works

Research progress of the netrins and their receptors in cancer

Gao, X., Ye, J., Huang, X., Huang, S., Luo, W., Zeng, D., Li, S., Tang, M., Mai, R., Li, Y., et al. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18241 · Cited by 6 · see citing works

Expanding ligand-receptor interaction networks for axon guidance: Structural insights into signal crosstalk and specificity

Zhu, S., Jaworski, A., & Meijers, R. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.102999 · Cited by 5 · see citing works

A comprehensive analysis of immunotherapy in advanced endometrial cancer (Review)

Wang, L., Liu, L., Huo, D., & Zhang, Y. (2023) · Oncology Letters · doi:10.3892/ol.2023.14210 · Cited by 5 · see citing works

Targeting of netrin-1 by monoclonal antibody NP137 inhibits the EMT in cancer

Xia, X., Yin, K., & Wang, S. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-008937 · Cited by 5 · see citing works

Microfluidic Devices for Studying the Effect of Netrin‐1 on Neutrophil and Breast Cancer Cell Migration

Hipolito, J., Peretz‐Soroka, H., Moya, A., Booy, E. P., Yang, K., Gupta, M., Meier, M., McKenna, S. A., Koch, M., Santos, S. C., et al. (2018) · Advanced Biosystems · doi:10.1002/adbi.201700178 · Cited by 5 · see citing works

Local uncoordinated gene 5H2 contributes to nerve injury‐induced mechanical allodynia associated to its role in autophagy

Chen, J., Huang, Z., Xiao, P., Yu, J., & Liao, S. (2020) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13430 · Cited by 5 · see citing works

Ventricular Netrin-1 deficiency leads to defective pyramidal decussation and mirror movement in mice

Hu, L., Liu, X.-Y., Zhao, L., Hu, Z., Li, Z.-X., Liu, W.-T., Song, N., Hu, Y.-Q., Jiang, L.-P., Zhang, L., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06719-1 · Cited by 4 · see citing works

GO-CRISPR: A highly controlled workflow to discover gene essentiality in loss-of-function screens

Perampalam, P., McDonald, J. I., & Dick, F. A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0315923 · Cited by 4 · see citing works

La nétrine-1, une nouvelle cible antitumorale

Bellina, M., & Bernet, A. (2022) · médecine/sciences · doi:10.1051/medsci/2022038 · Cited by 3 · see citing works

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network

Ichim, G., Gibert, B., Adriouch, S., Brenner, C., Davoust, N., Desagher, S., Devos, D., Dokudovskaya, S., Dubrez, L., Estaquier, J., et al. (2022) · Biomolecules · doi:10.3390/biom12070901 · Cited by 3 · see citing works

Investigation of dynamic solution interactions between NET-1 and UNC-5B by multi-wavelength analytical ultracentrifugation

Gabir, H., Gupta, M., Meier, M., Heide, F., Koch, M., Stetefeld, J., & Demeler, B. (2023) · European Biophysics Journal · doi:10.1007/s00249-023-01644-1 · Cited by 3 · see citing works

Possible Role of Netrin-1/Deleted in Colorectal Cancer/Vascular Endothelial Growth Factor Signaling Pathway in the Pathogenesis of Placenta Accreta Spectrum: A Case-control Study

Badary, D. M., Elsaied, H., Abdel-Fadeil, M. R., Ali, M. K., Abou-Taleb, H., & Iraqy, H. M. (2024) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0000000000001017 · Cited by 3 · see citing works

Cryo-EM reveals molecular mechanisms underlying the inhibitory effect of netrin-4 on laminin matrix formation

Kulczyk, A., McKee, K. K., & Yurchenco, P. D. (2025) · Nature Communications · doi:10.1038/s41467-025-62814-7 · Cited by 2 · see citing works

Pan-cancer analysis reveals netrin-1 receptors as potential tumor biomarkers and immune-related therapeutic targets

Gao, Y., Hu, Y., Zhu, Y., Gao, X., Hao, W., Chen, X., & Zheng, Z. (2025) · Scientific Reports · doi:10.1038/s41598-025-28437-0 · Cited by 2 · see citing works

Netrin-1 and UNC5B Cooperate with Integrins to Mediate YAP-Driven Cytostasis

Pearson, J. D., Huang, K., Pena, L. G. D., Ducarouge, B., Mehlen, P., & Bremner, R. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0101 · Cited by 2 · see citing works

Identifying the molecular basis of Laminin N-terminal domain Ca2+ binding using a hybrid approach

Legare, S., Heide, F., Gabir, H., Rafiei, F., Meier, M., Padilla‐Meier, G. P., Koch, M., & Stetefeld, J. (2024) · Biophysical Journal · doi:10.1016/j.bpj.2024.06.005 · Cited by 2 · see citing works

Interactions of netrin-1 through its glycosylation sites immobilize Deleted in Colorectal Cancer (DCC) by favoring its constitutive clusteringPreprint

Uriot, K., Blanc, O., Audugé, N., Faklaris, O., Blanc, O., Chaverot, N., Bloch‐Gallego, E., Borghi, N., Coppey‐Moisan, M., & Girard, P. P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.26.563740 · Cited by 2 · see citing works

"Netrin-slaying nanoparticles: A new frontier in cancer therapy"

Sherawat, V., & Sharma, D. (2025) · BBA Advances · doi:10.1016/j.bbadva.2025.100163 · Cited by 1 · see citing works

Neuroprotective Effects of Cerium Oxide Nanoparticles During Spaceflight

Carmignani, A., Marino, A., Battaglini, M., di Leo, N., Carrubba, E., Balsamo, M., Valentini, G., Mascetti, G., Perilli, S., Boni, F. D., et al. (2026) · Small Science · doi:10.1002/smsc.70271 · Cited by 1 · see citing works

A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression

Kobayashi, H., Iida, T., Ochiai, Y., Sakai, A., White, R. A., Zeng, Y., Zhi, X., Qian, J., Wu, F., Zheng, B., et al. (2026) · Cancer Cell · doi:10.1016/j.ccell.2026.06.018 · Cited by 1 · see citing works

Axon guidance: Netrins

Tessier‐Lavigne, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814407-7.00004-3 · Cited by 1 · see citing works

Involvement of Netrin/Unc-5 Interaction in Ciliary Beating and in Pattern Formation of the Ciliary Band-Associated Strand (CBAS) in the Sea Urchin, Hemicentrotus pulcherrimus

Katow, H., Abe, K., Katow, T., Yoshida, H., & Kiyomoto, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186587 · Cited by 1 · see citing works

Editorial: Misguided Macrophage and Risk of Coronary Atherosclerosis

Md, A. A. (2016) · Journal of Vascular Medicine & Surgery · doi:10.4172/2329-6925.1000e118 · Cited by 1 · see citing works

Netrin signaling mediates survival of dormant epithelial ovarian cancer cellsPreprint

Perampalam, P., MacDonald, J. I., Zakirova, K., Passos, D. T., Ramos-Valdes, Y., Hervieu, M., Mehlen, P., Rottapel, R. K., Gibert, B., Correa, R. J. M., et al. (2023) · eLife · doi:10.7554/elife.91766.1 · Cited by 1 · see citing works

Netrin-1 regulates colorectal cancer stem cell self-renewal via a TFF3 dependent paracrine survival mechanismPreprint

Brisset, M., Radkova, K., Paradisi, A., Grandin, M., Stephan, L., Wagner, R., Dégletagne, C., Luiggi, F., Frydman, L., Heriot, A. G., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.28.650943 · Cited by 1 · see citing works

Macrophage-derived Netrin-1 participates in endometriosis-associated painPreprint

Ding, S., Guo, X., Zhu, L., Wang, J., Li, T., Yu, Q. P., & Zhang, X. (2019) · doi:10.21203/rs.2.17387/v1

Therapeutic targeting Netrin-1-positive invasive bladder cancer cells with oridoninPreprint

Yu, M., Li, Y., Sun, D., Xing, H., An, J., Yang, J., Wei, B., Liu, S., Kong, C., Yu, F., et al. (2020) · doi:10.21203/rs.3.rs-24126/v1

The Role of UNC-129 in Axon Guidance and Cell Migration During Caenorhabditis elegans Development

Sward, B., & Michèle, E. (2019) · TSpace (University of Toronto)

New kid on the block: Netrin‐1 as a novel player in the delicate molecular network of hepatic inflammation

Goeppert, B. F., & Roessler, S. K. (2022) · Hepatology · doi:10.1002/hep.32509

1064 Invasive breast tumour cells induce up regulation of tumour endothelial marker 8 (TEM8) in monocytes

Venanzi, F. M., Petrini, M., Fiammenghi, L., Ridolfi, R., Riccobon, A., Capitani, M., & Concetti, A. (2009) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(09)70357-x

Mechanistic insights into NET1–UNC5B complex formation and Its targeted disruption by NP137 fab and NET1 peptide competitors

Rafiei, F., Gupta, M., Kitova, E. N., Peters, O., Legare, S., Heide, F., Krahn, N., Bailey-Elkin, B. A., Akgül, Ş., Brisset, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-78641-3

Netrin-1 et son récepteur à dépendance UNC5B : régulation, signalisation pro-apoptotique et ciblage thérapeutique en contexte tumoral

Frydman, L. (2024) · doi:10.70675/1b632274z0a69z4521z8909zb7716dbc35f7

Combining chemotherapeutic agents and netrin‐1 interference potentiates cancer cell death

Paradisi, A., Creveaux, M., Gibert, B., Devailly, G., Redoulez, E., Neves, D., Cleyssac, E., Treilleux, I., Klein, C., Niederfellner, G. J., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302654 · Cited by 63 · see citing works

La nétrine-1, une nouvelle cible antitumorale

Bellina, M., & Bernet, A. (2022) · médecine/sciences · doi:10.1051/medsci/2022038 · Cited by 3 · see citing works