The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

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Macrophage Plasticity and Atherosclerosis Therapy

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Recent Highlights of ATVB Atherosclerosis

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Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

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The Neuroimmune Guidance Cue Semaphorin 3E is Expressed in Atherosclerotic Plaques and Regulates Macrophage Retention

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Macrophage activation in human diseases

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Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

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Macrophages and Dendritic Cells

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Aspirin‐triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E^−/− mice

Petri, M. H., Laguna‐Fernandez, A., Arnardottir, H., Wheelock, C. E., Perretti, M., Hansson, G. K., & Bäck, M. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13707 · Cited by 120 · see citing works

Recent Advances in Managing Atherosclerosis via Nanomedicine

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Hypoxia Induces Netrin-1 and Unc5b in Atherosclerotic Plaques

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Inflammation in atherosclerosis: Lessons and therapeutic implications

Libby, P., & Soehnlein, O. (2025) · Immunity · doi:10.1016/j.immuni.2025.09.012 · Cited by 115 · see citing works

Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging

Lehallier, B., Shokhirev, M. N., Wyss‐Coray, T., & Johnson, A. A. (2020) · Aging Cell · doi:10.1111/acel.13256 · Cited by 106 · see citing works

Endothelial Expression of Guidance Cues in Vessel Wall Homeostasis Dysregulation Under Proatherosclerotic Conditions

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mir33 Inhibition Overcomes Deleterious Effects of Diabetes on Atherosclerosis Plaque Regression in Mice

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Enhanced glycolysis and HIF-1α activation in adipose tissue macrophages sustains local and systemic interleukin-1β production in obesity

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Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications

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Vascular Smooth Muscle Cells Contribute to Atherosclerosis Immunity

Hu, D., Yin, C., Luo, S., Habenicht, A. J. R., & Mohanta, S. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01101 · Cited by 100 · see citing works

Netrin-1 controls sympathetic arterial innervation

Brunet, I., Gordon, E. J., Han, J., Cristofaro, B., Broquères-You, D., Liu, C., Bouvrée, K., Zhang, J., Toro, R. D., Mathivet, T., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75181 · Cited by 100 · see citing works

Through the layers: how macrophages drive atherosclerosis across the vessel wall

Susser, L. I., & Rayner, K. J. (2022) · Journal of Clinical Investigation · doi:10.1172/jci157011 · Cited by 99 · see citing works

Macrophage profiling in atherosclerosis: understanding the unstable plaque

Gianopoulos, I., & Daskalopoulou, S. S. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-023-01023-z · Cited by 99 · see citing works

Ephs and ephrins resurface in inflammation, immunity, and atherosclerosis

Funk, S. D., & Orr, A. W. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.008 · Cited by 95 · see citing works

Cardiovascular Brain Circuits

Mohanta, S. K., Yin, C., Weber, C., Godinho‐Silva, C., Veiga‐Fernandes, H., Xu, Q. J., Chang, R. B., & Habenicht, A. J. R. (2023) · Circulation Research · doi:10.1161/circresaha.123.322791 · Cited by 93 · see citing works

Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes

KONES, R. J. (2013) · Vascular Health and Risk Management · doi:10.2147/vhrm.s37119 · Cited by 89 · see citing works

Human monocyte‐derived macrophages spontaneously differentiated in vitro show distinct phenotypes

Eligini, S., Crisci, M., Bono, E. B., Songia, P., Tremoli, E., Colombo, G. I., & Colli, S. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24301 · Cited by 87 · see citing works

Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease

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Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1

Qian, W., Hadi, T., Silvestro, M., Ma, X., Rivera, C. F., Bajpai, A., Li, R., Zhang, Z., Qu, H., Tellaoui, R. S., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27874-5 · Cited by 83 · see citing works

Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo

Iqbal, A. J., Barrett, T. J., Taylor, L., McNeill, E., Manmadhan, A., Recio, C., Carmineri, A., Brodermann, M. H., White, G. E., Cooper, D., et al. (2016) · eLife · doi:10.7554/elife.15190 · Cited by 79 · see citing works

Atherosclerosis and Coronary Artery Disease

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Neural Mechanisms in Cardiovascular Health and Disease

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Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications

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Development and Function of Arterial and Cardiac Macrophages

Świrski, F. K., Robbins, C. S., & Nahrendorf, M. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.11.004 · Cited by 73 · see citing works

Combining evidence from four immune cell types identifies DNA methylation patterns that implicate functionally distinct pathways during Multiple Sclerosis progression

Ewing, E., Kular, L., Fernandes, S. J., Karathanasis, N., Lagani, V., Ruhrmann, S., Tsamardinos, I., Tegner, J. N., Piehl, F., Gómez-Cabrero, D., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.04.042 · Cited by 74 · see citing works

RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling

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Dendritic cells in atherosclerosis

Subramanian, M., & Tabas, I. A. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0400-x · Cited by 72 · see citing works

The role of monocytosis and neutrophilia in atherosclerosis

Chistiakov, D. A., Grechko, A. V., Myasoedova, V. A., Melnichenko, A. А., & Orekhov, A. N. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13462 · Cited by 74 · see citing works

Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities

Stroope, C., Nettersheim, F. S., Coon, B. G., Finney, A. C., Schwartz, M. A., Ley, K. F., Rom, O., & Yurdagul, A. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01015-w · Cited by 72 · see citing works

Regression of Atherosclerosis: Insights from Animal and Clinical Studies

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RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism

Senatus, L. M., López‐Díez, R., Egaña-Gorroño, L., Liu, J., Hu, J., Daffu, G. K., Li, Q., Rahman, K., Vengrenyuk, Y., Barrett, T. J., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.137289 · Cited by 68 · see citing works

The Epigenetic Memory of Monocytes and Macrophages as a Novel Drug Target in Atherosclerosis

Bekkering, S., Joosten, L. A. B., van der Meer, J. W. M., Netea, M. G., & Riksen, N. P. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.01.008 · Cited by 65 · see citing works

Chemokines Control Mobilization, Recruitment, and Fate of Monocytes in Atherosclerosis

Drechsler, M. D., Duchêne, J., & Soehnlein, O. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304649 · Cited by 65 · see citing works

Netrin-1 Is a Critical Autocrine/Paracrine Factor for Osteoclast Differentiation

Mediero, A., Ramkhelawon, B., Pérez‐Aso, M., Moore, K. J., & Cronstein, B. N. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2421 · Cited by 64 · see citing works

From proliferation to proliferation: monocyte lineage comes full circle

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The neuroimmune guidance cue netrin‐1 controls resolution programs and promotes liver regeneration

Schlegel, M., Köhler, D., Körner, A., Granja, T., Straub, A., Giera, M. A., & Mirakaj, V. (2015) · Hepatology · doi:10.1002/hep.28347 · Cited by 64 · see citing works

Immunomodulatory Functions of Neuronal Guidance Proteins

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Novel mediators and mechanisms in the resolution of infectious inflammation: evidence for vagus regulation

Serhan, C. N., de la Rosa, X., & Jouvene, C. C. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12871 · Cited by 63 · see citing works

Netrin-1: An emerging player in inflammatory diseases

Xia, X., Hu, Z., Wang, S.-J., & Yin, K. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.01.003 · Cited by 67 · see citing works

Regulation and consequences of monocytosis

Dutta, P., & Nahrendorf, M. (2014) · Immunological Reviews · doi:10.1111/imr.12219 · Cited by 64 · see citing works

Immunotherapy for the prevention of atherosclerotic cardiovascular disease: Promise and possibilities

Khambhati, J., Engels, M., Allard‐Ratick, M., Sandesara, P. B., Quyyumi, A. A., & Sperling, L. S. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.07.007 · Cited by 63 · see citing works

Cholesterol in the Cell Membrane—An Emerging Player in Atherogenesis

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Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis

Rojas, J., Salazar, J. J., Martínez, M. S., Palmar, J., Bautista, J., Chávez-Castillo, M., Gómez, A., & Bermúdez, V. (2015) · Scientifica · doi:10.1155/2015/851252 · Cited by 63 · see citing works

Adult bone marrow mesenchymal and neural crest stem cells are chemoattractive and accelerate motor recovery in a mouse model of spinal cord injury

Neirinckx, V., Agirman, G., Coste, C., Marquet, A., Dion, V., Rogister, B., Franzen, R., & Wislet‐Gendebien, S. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0202-2 · Cited by 58 · see citing works

Regression of Atherosclerosis: The Journey From the Liver to the Plaque and Back.

Fisher, E. (2016) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.301926 · Cited by 55 · see citing works

Myeloid-Specific IκB Kinase β Deficiency Decreases Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

Park, S., Sui, Y., Gizard, F., Xu, J., Rios-Pilier, J., Helsley, R. N., Han, S., & Zhou, C. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.254573 · Cited by 55 · see citing works

Syndecan-1 Modulates the Motility and Resolution Responses of Macrophages

Angsana, J., Chen, J., Smith, S. V., Xiao, J., Wen, J., Liu, L., Haller, C. A., & Chaikof, E. L. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304720 · Cited by 55 · see citing works

Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit?

Layne, K. A., Ferro, A., & Passacquale, G. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv201 · Cited by 53 · see citing works

The research progression of Netrin-1 in atherosclersis

Zhao, W., & Guan, X. (2013) · Int J Immunol · doi:10.3760/cma.j.issn.1673-4394.2013.06.011

Abstract 583: Targeting of Macrophage Netrin-1 Expression Promotes Plaque Regression and Resolution of Chronic Inflammation in Atherosclerosis

Schlegel, M., Sharma, M., Afonso, M. S., Beckett, L., Babunovic, S., & Moore, K. J. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.38.suppl_1.583

Atherosclerosis

Lu, H. S., & Daugherty, A. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835c7bb7 · Cited by 1 · see citing works

Abstract 605: Macrophage-derived Netrin-1 Reshapes the Immune Cell Repertoire in the Atherosclerotic Plaque and Impairs Plaque Regression

Schlegel, P. M., Sharma, M., Brown, E. J., Afonso, M. S., Koelwyn, G. J., Corr, E. M., Solingen, C. V., Shanley, L. C., & Moore, K. J. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.39.suppl_1.605

The Ins and Outs of Inflammatory Cells in Atheromata

Świrski, F. K., Nahrendorf, M., & Libby, P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.012 · Cited by 30 · see citing works