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Cited by 319

The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.

Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

Open access
Dotto, G. Paolo, Rustgi, Anil K.·2016·Cancer Cell

Abstract

SUMMARY Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and a major cause of cancer mortality. These highly heterogeneous tumors arise from closely interconnected epithelial cell populations with intrinsic self-renewal potential inversely related to the stratified differentiation program. SCCs can also originate from simple or pseudo-stratified epithelia through activation of quiescent cells and/or a switch in cell fate determination. Here, we focus on specific determinants implicated in the development of SCCs by recent large-scale genomic, genetic and epigenetic studies and complementary functional analysis. This evidence indicates that SCCs from various body sites, while clinically treated as separate entities, have common determinants, pointing to a unified perspective of the disease and potential new avenues for prevention and treatment.

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Crossref · 10.1016/j.ccell.2016.04.004

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Metadata

Authors
Dotto, G. P., & Rustgi, A. K.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2016-05
Volume
29
Issue
5
Pages
622-637
ISSN
1535-6108 (ISSN-L)
OpenAlex
W2346530374
Cited by
319
References
173
FWCI
21.60
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Squamous Cell Cancers: A Unified Perspective on Biology and Genetics. https://app.cochat.ai/papers/10.1016/j.ccell.2016.04.004
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Dotto, G. P., & Rustgi, A. K. (2016). Squamous Cell Cancers: A Unified Perspective on Biology and Genetics. Cancer Cell. https://doi.org/10.1016/j.ccell.2016.04.004

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.