GOLM1 modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasis
Open accessAbstract
The mechanism of cancer metastasis remains poorly understood. Using gene profiling of hepatocellular carcinoma (HCC) tissues, we have identified GOLM1 as a leading gene relating to HCC metastasis. GOLM1 expression is correlated with early recurrence, metastasis, and poor survival of HCC patients. Both gain- and loss-of-function studies determine that GOLM1 acts as a key oncogene by promoting HCC growth and metastasis. It selectively interacts with epidermal growth factor receptor (EGFR) and serves as a specific cargo adaptor to assist EGFR/RTK anchoring on the trans-Golgi network (TGN) and recycling back to the plasma membrane, leading to prolonged activation of the downstream kinases. These findings reveal the functional role of GOLM1, a Golgi-related protein, in EGFR/RTK recycling and metastatic progression of HCC.
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Dysregulation of GARGs has been implicated in tumor progression, therapy resistance, and remodeling of the immune microenvironment across multiple cancer types.
“Dysregulation of GARGs has been implicated in tumor progression, therapy resistance, and remodeling of the immune microenvironment across multiple cancer types.”
From Construction and validation of golgi apparatus-related genes as predictors of the immune microenvironment and prognosis in colorectal cancer (2026) · cites this paper as [14]
The Results and Discussion (page numbers unavailable in our copy) identify GOLM1 as an upregulated Golgi-associated gene that promotes hepatocellular carcinoma growth and metastasis. They do not establish that GARGs as a group drive therapy resistance or immune-microenvironment remodeling across multiple cancer types. (LLM, conf=0.87)
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- Authors
- Ye, Q.-H., Zhu, W.-W., Zhang, J.-B., Qin, Y., Lu, M., Lin, G.-L., Guo, L., Zhang, B., Lin, Z.-H., Roessler, S., Forgues, M., Jia, H.-L., Lu, L., Zhang, X.-F., Lian, B.-F., Xie, L., Dong, Q.-Z., Tang, Z.-Y., Wang, X. W., & Qin, L.-X.
- Affiliations
- Fudan University (CN)
- National Institutes of Health (US)
- Shanghai Center For Bioinformation Technology (CN)
- Shanghai Medical College of Fudan University (CN)
- Corresponding author
- Wang, Xin Wei
- Qin, Lun-Xiu
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 30
- Issue
- 3
- Pages
- 444-458
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC5021625
- OpenAlex
- W2514993735
- Cited by
- 228
- References
- 44
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 26 · 2023: 29 · 2022: 24 · 2021: 46 · 2020: 27 · 2019: 25 · 2018: 19 · 2017: 10 · 2016: 2
- FWCI
- 12.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- State Key Basic Research Program of China (2013CB910500, 2009CB521701)
- National Key Project for Infectious Disease of China (2012ZX10002012)
- National Natural Science Foundation of China (81472677, 81372654, 81071993, 30872505, 30672037, 30300400, 30700991)
- National Cancer Institute (Z01 BC 010313, Z01 BC 010877)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Keywords
- GOLM1, hepatocellular carcinoma, metastasis, EGFR, receptor tyrosine kinase, trans-Golgi network, cargo adaptors, oncogenes, tumor recurrence, kinase activation
- MeSH terms
- Adolescent, Adult, Aged, Animals, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Male, Membrane Proteins, Mice, Inbred BALB C, Mice, Nude, Middle Aged, Neoplasm Metastasis, Transfection, Up-Regulation, Cell Line, Tumor, Mice, Young Adult, Heterografts, ErbB Receptors
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