The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment
Open accessAbstract
Summary We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single cell gene expression profiles to define three tumor-intrinsic transcriptional subtypes designated as proneural, mesenchymal, and classical. Transcriptomic subtype multiplicity correlated with increased intratumoral heterogeneity and presence of tumor microenvironment. In silico cell sorting identified macrophages/microglia, CD4+ T lymphocytes, and neutrophils in the glioma microenvironment. NF1 deficiency resulted in increased tumor-associated macrophages/microglia infiltration. Longitudinal transcriptome analysis showed that expression subtype is retained in 55% of cases. Gene signature-based tumor microenvironment inference revealed a decrease in invading monocytes and a subtype-dependent increase in macrophages/microglia cells upon disease recurrence. Hypermutation at diagnosis or at recurrence associated with CD8+ T cell enrichment. Frequency of M2 macrophages detection associated with short-term relapse after radiation therapy.
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Metadata
- Authors
- Wang, Q., Hu, B., Hu, X., Kim, H., Squatrito, M., Scarpace, L., deCarvalho, A. C., Lyu, S., Li, P., Li, Y., Barthel, F., Cho, H. J., Lin, Y.-H., Satani, N., Martinez-Ledesma, E., Zheng, S., Chang, E., Sauvé, C.-E. G., Olar, A., Lan, Z. D., Finocchiaro, G., Phillips, J. J., Berger, M. S., Gabrusiewicz, K. R., Wang, G., Eskilsson, E., Hu, J., Mikkelsen, T., DePinho, R. A., Muller, F., Heimberger, A. B., Sulman, E. P., Nam, D.-H., & Verhaak, R. G. W.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 32
- Issue
- 1
- Pages
- 42-56.e6
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2951880440
- Cited by
- 1,995
- References
- 16
- FWCI
- 69.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Wang, Q., Hu, B., Hu, X., Kim, H., Squatrito, M., Scarpace, L., deCarvalho, A. C., Lyu, S., Li, P., Li, Y., Barthel, F., Cho, H. J., Lin, Y.-H., Satani, N., Martinez-Ledesma, E., Zheng, S., Chang, E., Sauvé, C.-E. G., Olar, A., . . . Verhaak, R. G. W. (2017). Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. https://doi.org/10.1016/j.ccell.2017.06.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
