The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer
Open accessAbstract
Tumors are influenced by the mechanical properties of their microenvironment. Using patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver metastases than in primary colorectal tumors. Highly activated metastasis-associated fibroblasts increase tissue stiffness, which enhances angiogenesis and anti-angiogenic therapy resistance. Drugs targeting the renin-angiotensin system, normally prescribed to treat hypertension, inhibit fibroblast contraction and extracellular matrix deposition, thereby reducing liver metastases stiffening and increasing the anti-angiogenic effects of bevacizumab. Patients treated with bevacizumab showed prolonged survival when concomitantly treated with renin-angiotensin inhibitors, highlighting the importance of modulating the mechanical microenvironment for therapeutic regimens.
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Cited by
Yuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., & Xiao, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01744-8 · Cited by 977
Self-citationThe immunological and metabolic landscape in primary and metastatic liver cancer
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Bhattacharjee, S., Hamberger, F., Ravichandra, A., Miller, M., Nair, A., Affo, S., Filliol, A., Chin, L., Savage, T. M., Yin, D., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146987 · Cited by 367
Self-citationColorectal liver metastasis: molecular mechanism and interventional therapy
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Metadata
- Authors
- Shen, Y., Wang, X., Lu, J., Salfenmoser, M., Wirsik, N. M., Schleussner, N., Imle, A., Freire Valls, A., Radhakrishnan, P., Liang, J., Wang, G., Muley, T., Schneider, M., Ruiz de Almodovar, C., Diz-Muñoz, A., & Schmidt, T.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 37
- Issue
- 6
- Pages
- 800-817.e7
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W3033089248
- Cited by
- 339
- References
- 97
- FWCI
- 17.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer. https://app.cochat.ai/papers/10.1016/j.ccell.2020.05.005
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- Shen, Y., Wang, X., Lu, J., Salfenmoser, M., Wirsik, N. M., Schleussner, N., Imle, A., Freire Valls, A., Radhakrishnan, P., Liang, J., Wang, G., Muley, T., Schneider, M., Ruiz de Almodovar, C., Diz-Muñoz, A., & Schmidt, T. (2020). Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer. Cancer Cell. https://doi.org/10.1016/j.ccell.2020.05.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
