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Arsenic and an Old Place: Rescuing p53 Mutants in Cancer
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“the specificity of the p53 structure,11,12 the smooth surface without an ideal drug-binding pocket,13 and the difficulty to restore p53 function, have stalled drug research against p53 for decades”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [13]
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Research works printed but not linked: 8
- Baugh, 2018, Why are there hotspot mutations in the TP53 gene in human cancers?, Cell Death Differ., 25, 154, 10.1038/cdd.2017.180 · DOI · Paper page
- Blanden, 2020, Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants, eLife, 9, e61487, 10.7554/eLife.61487 · DOI · Paper page
- Boeckler, 2008, Targeted rescue of a destabilized mutant of p53 by an in silico screened drug, Proc. Natl. Acad. Sci. USA, 105, 10360, 10.1073/pnas.0805326105 · DOI · Paper page
- Chen, 2020, Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site, Cancer Cell
- Kaiming, 2018, Arsenic trioxide preferentially binds to the ring finger protein PML: understanding target selection of the drug, Metallomics, 10, 1564, 10.1039/C8MT00202A · DOI
- Shen, 2013, Arsenic binding to proteins, Chem. Rev., 113, 7769, 10.1021/cr300015c · DOI · Paper page
- Yu, 2014, Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism, Oncotarget, 5, 8879, 10.18632/oncotarget.2432 · DOI · Paper page
- Zhang, 2018, APR-246 reactivates mutant p53 by targeting cysteines 124 and 277, Cell Death Dis., 9, 439, 10.1038/s41419-018-0463-7 · DOI · Paper page
Cited by
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Design, synthesis, and evaluation of p53Y220C acetylation targeting chimeras (AceTACs)
Hu, X., Kabir, M., Lin, Y., Xiong, Y., Parsons, R. E., Gu, W., & Jin, J. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01497 · Cited by 9
Metadata
- Authors
- Loh, S. N.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 39
- Issue
- 2
- Pages
- 140-142
- ISSN
- 1535-6108
- Cited by
- 15
- References
- 0
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Funders
- National Institutes of Health (R01 CA200800)
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Arsenic and an Old Place: Rescuing p53 Mutants in Cancer. https://app.cochat.ai/papers/10.1016/j.ccell.2021.01.012
- The paper
- Loh, S. N. (2021). Arsenic and an Old Place: Rescuing p53 Mutants in Cancer. Cancer Cell. https://doi.org/10.1016/j.ccell.2021.01.012
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
