The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Why are there hotspot mutations in the TP53 gene in human cancers?
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In the citing paper
“The most frequent mutation locations of the DBD are known as “hotspots,” which contain codons G245, R249, R248, R282, R273, Y220, and R175144”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [144]
In the citing paper
“Most TP53 mutations are missense mutations located in the DBD.3,4,203,205,380”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [203]
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Citations
Cites
Leaver-Fay (2011) · doi:10.1016/b978-0-12-381270-4.00019-6 · Cited by 1,904
Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53
Denissenko, M. F., Pao, A., Tang, M.-S., & Pfeifer, G. P. (1996) · Science · doi:10.1126/science.274.5286.430 · Cited by 1,650
Cited by
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Challenges and Opportunities for Pancreatic Cancer Immunotherapy
Bear, A. S., Vonderheide, R. H., & O'Hara, M. H. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.08.004 · Cited by 674
Regulating tumor suppressor genes: post-translational modifications
Chen, L., Liu, S., & Tao, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0196-9 · Cited by 449
A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies
Boettcher, S., Miller, P. G., Sharma, R., McConkey, M., Leventhal, M., Krivtsov, A. V., Giacomelli, A. O., Wong, W., Kim, J., Chao, S., et al. (2019) · Science · doi:10.1126/science.aax3649 · Cited by 441
Targeting Therapies for the p53 Protein in Cancer Treatments
Levine, A. J. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055455 · Cited by 84
Self-citation
Metadata
- Authors
- Baugh, E. H., Ke, H., Levine, A. J., Bonneau, R. A., & Chan, C. S.
- Venue
- Cell Death & Differentiation
- Published
- 2017-11-03
- Volume
- 25
- Issue
- 1
- Pages
- 154-160
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W2765694924
- Cited by
- 607
- References
- 2
- FWCI
- 11.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Why are there hotspot mutations in the TP53 gene in human cancers? https://app.cochat.ai/papers/10.1038/cdd.2017.180
- The paper
- Baugh, E. H., Ke, H., Levine, A. J., Bonneau, R. A., & Chan, C. S. (2018). Why are there hotspot mutations in the TP53 gene in human cancers? Cell Death & Differentiation. https://doi.org/10.1038/cdd.2017.180
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
