The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
Open accessAbstract
Summary The mesenchymal subtype of glioblastoma is thought to be determined by both cancer cell intrinsic alterations and extrinsic cellular interactions, but remains poorly understood. Here, we dissect glioblastoma-to-microenvironment interactions by single-cell RNA-sequencing analysis of human tumors and model systems, combined with functional experiments. We demonstrate that macrophages induce a transition of glioblastoma cells into mesenchymal-like (MES-like) states. This effect is mediated, both in vitro and in vivo, by macrophage-derived Oncostatin M (OSM) that interacts with its receptors (OSMR or LIFR) in complex with GP130 on glioblastoma cells and activates STAT3. We show that MES-like glioblastoma states are also associated with increased expression of a mesenchymal program in macrophages and with increased cytotoxicity of T cells, highlighting extensive alterations of the immune microenvironment with potential therapeutic implications.
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Metadata
- Authors
- Hara, T., Chanoch-Myers, R., Mathewson, N. D., Myskiw, C., Atta, L., Bussema, L., Eichhorn, S. W., Greenwald, A. C., Kinker, G. S., Rodman, C., Gonzalez Castro, L. N., Wakimoto, H., Rozenblatt-Rosen, O., Zhuang, X., Fan, J., Hunter, T., Verma, I. M., Wucherpfennig, K. W., Regev, A., Suvà, M. L., & Tirosh, I.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 39
- Issue
- 6
- Pages
- 779-792.e11
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W3165863602
- Cited by
- 593
- References
- 62
- FWCI
- 41.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hara, T., Chanoch-Myers, R., Mathewson, N. D., Myskiw, C., Atta, L., Bussema, L., Eichhorn, S. W., Greenwald, A. C., Kinker, G. S., Rodman, C., Gonzalez Castro, L. N., Wakimoto, H., Rozenblatt-Rosen, O., Zhuang, X., Fan, J., Hunter, T., Verma, I. M., Wucherpfennig, K. W., Regev, A., . . . Tirosh, I. (2021). Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Cancer Cell. https://doi.org/10.1016/j.ccell.2021.05.002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
