Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer

The Sequence Alignment/Map format and SAMtools

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The blockade of immune checkpoints in cancer immunotherapy

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Comprehensive molecular portraits of human breast tumours

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A framework for variation discovery and genotyping using next-generation DNA sequencing data

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The Multi-Dimensional Biomarker Landscape in Cancer Immunotherapy

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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors

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Performance of spectral flow cytometry and mass cytometry for the study of innate myeloid cell populations

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Focused acoustic vortex-mediated sonochemotherapy for the amplification of immunogenic cell death combined with checkpoint blockade to potentiate cancer immunotherapy

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Single-cell RNA sequencing in cancer research: discovering novel biomarkers and therapeutic targets for immune checkpoint blockade

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The multifaceted roles of CD4+ T cells and MHC class II in cancer surveillance

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GITR and TIGIT immunotherapy provokes divergent multicellular responses in the tumor microenvironment of gastrointestinal cancers

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Single-cell analyses reveal evolution mimicry during the specification of breast cancer subtype

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Stem-like CD8+ T cells in cancer

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Optimal timing of anti-PD-1 antibody combined with chemotherapy administration in patients with NSCLC

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SPP1+ macrophages in tumor immunosuppression: mechanisms and therapeutic implications

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Single-cell chemokine receptor profiles delineate the immune contexture of tertiary lymphoid structures in head and neck squamous cell carcinoma

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Deciphering pathogenic cellular module at single-cell resolution in checkpoint inhibitor-related pneumonitis

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Immune Checkpoints in B Cells: Unlocking New Potentials in Cancer Treatment

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Interferon-induced senescent CD8 + T cells reduce anti-PD1 immunotherapy efficacy in early triple-negative breast cancer

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Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy

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The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges

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TREM2+ macrophages: a key role in disease development

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TREM2-mediated regulation of myeloid cells in the tumor microenvironment: new insights and therapeutic prospects

Huang, Y., & Fang, W. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01152-9 · Cited by 30

Efficacy and safety of first-line treatment for metastatic triple-negative breast cancer: A network meta-analysis

Shi, M., Li, Z., Shen, G., Wang, T., Li, J., Wang, M., Liu, Z., Zhao, F., Ren, D., & Zhao, J. (2023) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2023.06.002 · Cited by 24

Deciphering tumor-infiltrating dendritic cells in the single-cell era

Huang, Q., Wang, F., Di, H., Li, X., Li, X., Lei, T., Yue, J., & Liu, C. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00459-2 · Cited by 27

Immune-restoring CAR-T cells display antitumor activity and reverse immunosuppressive TME in a humanized ccRCC mouse model

Wang, Y., Cho, J.-W., Kastrunes, G. M., Buck, A., Razimbaud, C., Culhane, A. C., Sun, J., Braun, D. A., Choueiri, T. K., Wu, C. J., et al. (2024) · iScience · doi:10.1016/j.isci.2024.108879 · Cited by 25

Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma

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Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma

Sun, B., Wang, Z.-T., Chen, K.-Z., Song, Y., Wu, J.-F., Zhang, D., Sun, G.-Q., Zhou, J., Fan, J., Hu, B., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02079-z · Cited by 23

Revisiting the CXCL13/CXCR5 axis in the tumor microenvironment in the era of single-cell omics: Implications for immunotherapy

Gu, X., Li, D., Wu, P., Zhang, C., Cui, X., Shang, D., Ma, R., Liu, J., Sun, N., & He, J. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217278 · Cited by 25

Single-cell spatial transcriptomics unravels cell states and ecosystems associated with clinical response to immunotherapy

Abdulrahman, Z., Slieker, R. C., McGuire, D., Welters, M. J. P., van Poelgeest, M. I. E., & van der Burg, S. H. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-011308 · Cited by 24

Efficacy, safety and exploratory analysis of neoadjuvant tislelizumab (a PD-1 inhibitor) plus nab-paclitaxel followed by epirubicin/cyclophosphamide for triple-negative breast cancer: a phase 2 TREND trial

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Macrophage-camouflaged epigenetic nanoinducers enhance chemoimmunotherapy in triple negative breast cancer

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Immunogenicity and efficacy of pembrolizumab and doxorubicin in a phase I trial for patients with metastatic triple-negative breast cancer

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Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity

Tooley, K., Jerby‐Arnon, L., Escobar, G., Krovi, S. H., Mangani, D., Dandekar, G., Cheng, H., Madi, A., Goldschmidt, E., Lambden, C., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101640 · Cited by 29

Mapping of the T-cell Landscape of Biliary Tract Cancer Unravels Anatomic Subtype-Specific Heterogeneity

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Epigenetic Regulation of Stromal and Immune Cells and Therapeutic Targets in the Tumor Microenvironment

Liu, K., Li, Y., Shen, M., Xu, W., Wu, S., Yang, X., Zhang, B., & Lin, N. (2025) · Biomolecules · doi:10.3390/biom15010071 · Cited by 23

Role of CD4+ T cells in cancer immunity: a single-cell sequencing exploration of tumor microenvironment

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ICI-induced cardiovascular toxicity: mechanisms and immune reprogramming therapeutic strategies

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Applying causal discovery to single-cell analyses using CausalCell

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Progress and Challenges of Immunotherapy Predictive Biomarkers for Triple Negative Breast Cancer in the Era of Single-Cell Multi-Omics

Yu, J., Zhikun, G., & Wang, L. (2023) · Life · doi:10.3390/life13051189 · Cited by 22

Expansion of CD4+ cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: single-cell analysis and in vitro experiments

Hu, C., Sameshima, J., Yokomizo, S., Sueyoshi, T., Nagano, H., Miyahara, Y., Sakamoto, T., Fujii, S., Kiyoshima, T., Guy, T. V., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1305783 · Cited by 23

Tumor Microenvironment On‐A‐Chip and Single‐Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression

Ravi, K., Zhang, Y., Sakala, L., Manoharan, T. J. M., Pockaj, B. A., LaBaer, J., Park, J. G., & Nikkhah, M. (2025) · Advanced Science · doi:10.1002/advs.202413457 · Cited by 22

Single-cell meta-analysis of T cells reveals clonal dynamics of response to checkpoint immunotherapy

Shorer, O., Pinhasi, A., & Yizhak, K. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100842 · Cited by 21

A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer

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Heterogeneity of tumor-infiltrating myeloid cells in era of single-cell genomics

Chu, X., Zhang, Y., & Cheng, S. (2022) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2022.06.01 · Cited by 21

Immune-related biomarkers predict the prognosis and immune response of breast cancer based on bioinformatic analysis and machine learning

Zheng, X., Ma, H., Dong, Y., Fang, M., Wang, J., Xiong, X., Liang, J., Han, M., You, A., Yin, Q., et al. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01124-x · Cited by 22

Current understanding on TREM-2 molecular biology and physiopathological functions

Bharadwaj, S., Groza, Y., Mierzwicka, J. M., & Malý, P. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112042 · Cited by 23

Synergistic role of activated CD4+ memory T cells and CXCL13 in augmenting cancer immunotherapy efficacy

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Targeting B7-H3 inhibition-induced activation of fatty acid synthesis boosts anti-B7-H3 immunotherapy in triple-negative breast cancer

Jiang, Y., Qian, Z., Wang, C., Wu, D., Liu, L., Ning, X., You, Y., Mei, J., Zhao, X., & Zhang, Y. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010924 · Cited by 20

Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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Addition of immunotherapy to chemotherapy for metastatic triple-negative breast cancer: A systematic review and meta-analysis of randomized clinical trials

Huo, X., Shen, G., Liu, Z., Liang, Y., Li, J., Zhao, F., Ren, D., & Zhao, J. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103530 · Cited by 20

3D Collagen Fiber Concentration Regulates Treg Cell Infiltration in Triple Negative Breast Cancer

Gao, H., Tian, Q., Zhou, Y., Zhu, L., Lu, Y., Ma, Y., Feng, J., Jiang, Y., & Wang, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.904418 · Cited by 20

Immune Checkpoint Inhibitors and Other Immune Therapies in Breast Cancer: A New Paradigm for Prolonged Adjuvant Immunotherapy

Nicolini, A., Ferrari, P., & Carpi, A. (2022) · Biomedicines · doi:10.3390/biomedicines10102511 · Cited by 20

Oxidative stress in the tumor microenvironment in gastric cancer and its potential role in immunotherapy

Yu, Y., Wu, Y., Zhang, Y., Lu, M., & Su, X. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13630 · Cited by 20

PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127+ and KLRG1+ CD8 T cells

Hui, Z., Ren, Y., Zhang, D., Chen, Y., Yu, W., Cao, J., Liu, L., Wang, T., Xiao, S., Zheng, L., et al. (2023) · npj Precision Oncology · doi:10.1038/s41698-023-00384-x · Cited by 21

Deciphering breast cancer dynamics: insights from single-cell and spatial profiling in the multi-omics era

Xiong, X., Wang, X., Liu, C., Shao, Z.-M., & Yu, K. (2024) · Biomarker Research · doi:10.1186/s40364-024-00654-1 · Cited by 21

Spatial Architecture of Single-Cell and Vasculature in Tumor Microenvironment Predicts Clinical Outcomes in Triple-Negative Breast Cancer

Mi, H., Varadhan, R., Cimino‐Mathews, A., Emens, L. A., Santa-Maria, C. A., & Popel, A. S. (2024) · Modern Pathology · doi:10.1016/j.modpat.2024.100652 · Cited by 19

Analysis of single-cell and spatial transcriptomics in TNBC cell-cell interactions

Xin, Y., Ma, Q., Deng, Q., Wang, T., Wang, D., & Wang, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1521388 · Cited by 21

Genetically engineered macrophages reverse the immunosuppressive tumor microenvironment and improve immunotherapeutic efficacy in TNBC

Jiang, R., Yang, L., Liu, X., Xu, Y., Han, L., Chen, Y., Gao, G., Wang, M., Su, T., Li, H., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.03.024 · Cited by 22

Targeting CCR2+ macrophages with BET inhibitor overcomes adaptive resistance to anti-VEGF therapy in ovarian cancer

Wu, Y., Jennings, N. B., Sun, Y., Dasari, S. K., Bayraktar, E., Corvigno, S., Stur, E., Glassman, D., Mangala, L. S., Ahumada, A. L., et al. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-021-03885-z · Cited by 19

Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer

Orbach, S. M., Brooks, M. D., Zhang, Y., Campit, S., Bushnell, G. G., Decker, J. T., Rebernick, R. J., Chandrasekaran, S., Wicha, M. S., Jeruss, J. S., et al. (2022) · Clinical & Experimental Metastasis · doi:10.1007/s10585-022-10185-4 · Cited by 19

Single-cell RNA-sequencing uncovers compound kushen injection synergistically improves the efficacy of chemotherapy by modulating the tumor environment of breast cancer

Liu, X., Bai, M., Li, H., Ye, P., Duan, X., Wu, C., Huang, Z., Lu, S., Zhang, J., Zhao, Z., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.965342 · Cited by 19

Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer

Licata, L., Mariani, M., Rossari, F., Viale, G., Notini, G., Naldini, M. M., Bosi, C., Piras, M., Dugo, M., & Bianchini, G. (2023) · The Breast · doi:10.1016/j.breast.2023.03.014 · Cited by 19

Neoadjuvant chemotherapy-induced remodeling of human hormonal receptor-positive breast cancer revealed by single-cell RNA sequencing

Jia, F., Sun, S., Li, J., Wang, W., Huang, H., Hu, X., Pan, S., Chen, W., Shen, L., Yao, Y., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216656 · Cited by 19

From infection to immune exhaustion: The Epstein-Barr virus and its contribution to Immunosenescence

Hu, L., Zhu, T., Long, J., Luo, Q., & Lyu, X. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189421 · Cited by 20

Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets

Lai, L., Ran, S., Li, Y., Cui, J., Zhang, X., Yu, J., Zou, Y., Cheng, Z., Xia, J., & Wu, J. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02533-z · Cited by 24

Deciphering the tumour immune microenvironment cell by cell

Nabhan, M., Egan, D., Kreileder, M., Zhernovkov, V., Timosenko, E., Slidel, T. W. F., Dovedi, S. J., Glennon, K., Brennan, D. J., & Kölch, W. (2023) · Immuno-Oncology Technology · doi:10.1016/j.iotech.2023.100383 · Cited by 17

Single-cell omics: a new perspective for early detection of pancreatic cancer?

Wang, Q., Šabanović, B., Awada, A., Reina, C., Aicher, A., Tang, J., & Heeschen, C. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.112940 · Cited by 19

Immunological and clinicopathological features predict HER2-positive breast cancer prognosis in the neoadjuvant NeoALTTO and CALGB 40601 randomized trials

Rediti, M., Fernández-Martínez, A., Venet, D., Rothé, F., Hoadley, K. A., Parker, J. S., Singh, B., Campbell, J. D., Ballman, K. V., Hillman, D. W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42635-2 · Cited by 18

A Large-Scale Meta-Analysis Reveals Positive Feedback between Macrophages and T Cells That Sensitizes Tumors to Immunotherapy

Yang, J., Liu, Q., & Shyr, Y. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-2006 · Cited by 18

Mature tertiary lymphoid structures linked to HPV status and anti-PD-1 based chemoimmunotherapy response in head and neck squamous cell carcinoma

Zhang, L., Ren, S., Lan, T., Marco, V. D., Liu, N., Wei, B., Chen, Y., Wu, J., Li, Q., Wu, F., et al. (2025) · OncoImmunology · doi:10.1080/2162402x.2025.2528109 · Cited by 19

Dysregulation of NK and CD8+T Cells by the Microbiota Promotes the Progression of Lung Cancer

Hu, S., Zha, Y., Yang, W., Cui, K., & Cheng, M. (2022) · Journal of Immunology Research · doi:10.1155/2022/7057089 · Cited by 17

Single-cell sequencing and bulk RNA data reveal the tumor microenvironment infiltration characteristics of disulfidptosis related genes in breast cancer

Chen, Y., Jin, C., Cui, J., Diao, Y., Wang, R., Xu, R., Yao, Z., Wu, W., & Li, X. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05109-y · Cited by 17

Opioids and immune checkpoint inhibitors differentially regulate a common immune network in triple-negative breast cancer

Scarpa, J. R., Montagna, G., Plitas, G., Gulati, A., Fischer, G. W., & Mincer, J. S. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1267532 · Cited by 17

Unlocking the potential of T‐cell metabolism reprogramming: Advancing single‐cell approaches for precision immunotherapy in tumour immunity

Huang, L., Li, H., Zhang, C., Chen, Q., Liu, Z., Zhang, J., Luo, P., & Wei, T. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1620 · Cited by 18

Beyond Anti-PD-1/PD-L1: Improving Immune Checkpoint Inhibitor Responses in Triple-Negative Breast Cancer

Bullock, K. K., & Richmond, A. J. (2024) · Cancers · doi:10.3390/cancers16122189 · Cited by 18

Noninvasive in vivo imaging of macrophages: understanding tumor microenvironments and delivery of therapeutics

Gangadaran, P., Onkar, A., Rajendran, R. L., Goenka, A., Oh, J. M., Khan, F., Nagarajan, A. K., Muthu, S., Krishnan, A., Hong, C. M., et al. (2025) · Biomarker Research · doi:10.1186/s40364-025-00735-9 · Cited by 21

Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice

Preite, N. W., Borges, B. M., Kaminski, V. D. L., Ayupe, M. C., Gonçalves, L. M., dos Santos, B. V., Fonseca, D. L. M., Filgueiras, I. S., Salgado, C. L., Muxel, S. M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1347318 · Cited by 16

A novel carrier-free nanoparticle with stable distinctive three-dimensional structure for tumor-targeted precision chemoimmunotherapy

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Persistent EGFR/K-RAS/SIAH pathway activation drives chemo-resistance and early tumor relapse in triple-negative breast cancer

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